{
  "id": 4753,
  "label": "central nervous system cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002714",
  "properties": {
    "xrefs": [
      "DOID:3620",
      "EFO:0000326",
      "GARD:0027614",
      "ICD9:239.7",
      "MEDGEN:87593",
      "MESH:D016543",
      "NANDO:2100007",
      "NCIT:C4627",
      "SCTID:126951006",
      "UMLS:C0348374"
    ],
    "synonyms": [
      "CNS neoplasm",
      "central nervous system tumor",
      "central nervous system tumour",
      "CNS cancer",
      "CNS malignant neoplasms",
      "CNS neoplasms, malignant",
      "cancer of CNS",
      "cancer of central nervous system",
      "cancer of the CNS",
      "cancer of the central nervous system",
      "central nervous system cancer",
      "central nervous system neoplasms, malignant",
      "central nervous system tumours",
      "malignant CNS neoplasm",
      "malignant CNS neoplasms",
      "malignant CNS tumor",
      "malignant CNS tumour",
      "malignant central nervous system neoplasm",
      "malignant central nervous system tumor",
      "malignant central nervous system tumour",
      "malignant neoplasm of CNS",
      "malignant neoplasm of central nervous system",
      "malignant neoplasm of the CNS",
      "malignant neoplasm of the central nervous system",
      "malignant tumor of CNS",
      "malignant tumor of central nervous system",
      "malignant tumor of the CNS",
      "malignant tumor of the central nervous system",
      "malignant tumour of CNS",
      "malignant tumour of central nervous system",
      "malignant tumour of the CNS",
      "malignant tumour of the central nervous system"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A malignant neoplasm involving the central nervous system"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 20,
  "parents": [
    {
      "id": 7479,
      "label": "nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3093",
          "EFO:0007392",
          "ICD9:192",
          "ICD9:192.8",
          "ICD9:192.9",
          "MEDGEN:99231",
          "MESH:D009423",
          "NCIT:C4788",
          "SCTID:372063002",
          "UMLS:C0497549"
        ],
        "synonyms": [
          "nervous system neoplasm",
          "neural neoplasm",
          "neural tumor",
          "neural tumour",
          "tumor of the nervous system",
          "tumour of the nervous system",
          "cancer of nervous system",
          "malignant neoplasm of nervous system",
          "malignant neoplasm of the nervous system",
          "malignant nervous system neoplasm",
          "malignant nervous system tumor",
          "malignant nervous system tumour",
          "malignant tumor of nervous system",
          "malignant tumor of the nervous system",
          "malignant tumour of nervous system",
          "malignant tumour of the nervous system",
          "nervous system cancer",
          "nervous system neoplasms, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the nervous system."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005872"
    },
    {
      "id": 7694,
      "label": "central nervous system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000158",
          "MEDGEN:88335",
          "NCIT:C9293",
          "UMLS:C0085136"
        ],
        "synonyms": [
          "CNS neoplasm",
          "CNS tumor",
          "CNS tumour",
          "brain/spinal cord tumor",
          "brain/spinal cord tumour",
          "central nervous system neoplasm",
          "central nervous system neoplasm (disease)",
          "central nervous system tumor",
          "central nervous system tumour",
          "neoplasm of CNS",
          "neoplasm of central nervous system",
          "neoplasm of the central nervous system",
          "tumor of CNS",
          "tumor of central nervous system",
          "tumor of the CNS",
          "tumor of the central nervous system",
          "tumour of CNS",
          "tumour of central nervous system",
          "tumour of the CNS",
          "tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia."
      },
      "child_count": 20,
      "reference_id": "MONDO:0006130"
    }
  ],
  "children": [
    {
      "id": 3043,
      "label": "central nervous system primitive neuroectodermal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        7121
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060103",
          "GARD:0027536",
          "MEDGEN:854517",
          "NANDO:2200099",
          "NANDO:2200100",
          "NCIT:C5398",
          "UMLS:C3887678",
          "icd11.foundation:1711526170"
        ],
        "synonyms": [
          "CNS PNET",
          "CNS primitive neuroectodermal neoplasm",
          "CNS primitive neuroectodermal tumor",
          "CNS primitive neuroectodermal tumour",
          "central nervous system PNET",
          "central nervous system neuroectodermal tumor",
          "central nervous system neuroectodermal tumour",
          "central nervous system primitive neuroectodermal neoplasm",
          "central nervous system primitive neuroectodermal tumor",
          "central nervous system primitive neuroectodermal tumor (WHO grade IV)",
          "central nervous system primitive neuroectodermal tumour",
          "central nervous system primitive neuroectodermal tumour (WHO grade IV)",
          "central primitive neuroectodermal neoplasm",
          "central primitive neuroectodermal tumor",
          "central primitive neuroectodermal tumour",
          "primitive neuroectodermal tumor of central nervous system",
          "primitive neuroectodermal tumour of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuroectodermal tumor that involves the central nervous system."
      },
      "child_count": 16,
      "reference_id": "MONDO:0000640"
    },
    {
      "id": 3853,
      "label": "brain cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20429
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2006-2736",
          "DOID:1319",
          "GARD:0027584",
          "ICD10CM:C71",
          "ICD9:191",
          "ICD9:191.8",
          "ICD9:191.9",
          "ICD9:239.6",
          "MEDGEN:57796",
          "MESH:D001932",
          "NCIT:C3568",
          "SCTID:428061005",
          "UMLS:C0153633",
          "icd11.foundation:189650925"
        ],
        "synonyms": [
          "brain neoplasm",
          "tumor of the brain",
          "tumour of the brain",
          "brain cancer",
          "brain neoplasms, malignant",
          "cancer of brain",
          "cancer of the brain",
          "malignant brain neoplasm",
          "malignant brain tumor",
          "malignant neoplasm of brain",
          "malignant neoplasm of the brain",
          "malignant tumor of brain",
          "malignant tumor of the brain",
          "malignant tumour of brain",
          "malignant tumour of the brain",
          "adult brain tumor",
          "adult brain tumour",
          "adult malignant brain neoplasm",
          "malignant primary brain neoplasm",
          "malignant primary brain tumor",
          "malignant primary brain tumour",
          "malignant tumor of adult brain",
          "malignant tumour of adult brain",
          "BT - brain tumor",
          "BT - brain tumour",
          "brain neoplasm, adult",
          "brain tumor, adult",
          "neoplasm of unspecified nature of brain",
          "primary brain neoplasm",
          "primary brain tumor",
          "primary brain tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the brain."
      },
      "child_count": 18,
      "reference_id": "MONDO:0001657"
    },
    {
      "id": 4336,
      "label": "central nervous system sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2133",
          "GARD:0023088",
          "MEDGEN:272444",
          "NCIT:C5153",
          "UMLS:C1332892"
        ],
        "synonyms": [
          "CNS sarcoma",
          "central nervous system sarcoma",
          "sarcoma of CNS",
          "sarcoma of central nervous system",
          "sarcoma of the CNS",
          "sarcoma of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A sarcoma that arises from the central nervous system."
      },
      "child_count": 24,
      "reference_id": "MONDO:0002217"
    },
    {
      "id": 4634,
      "label": "primary central nervous system lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        4753,
        5530,
        6694,
        17548,
        17660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3234",
          "EFO:1000157",
          "GARD:0009318",
          "ICD9:200.5",
          "MEDGEN:79187",
          "MedDRA:10036685",
          "NCIT:C9301",
          "NORD:2002",
          "ONCOTREE:PCNSL",
          "Orphanet:46135",
          "SCTID:307649006",
          "UMLS:C0280803",
          "icd11.foundation:1133193893"
        ],
        "synonyms": [
          "CNS lymphoma",
          "PCNSL",
          "central nervous system lymphoma",
          "lymphoma of central nervous system",
          "malignant lymphomas of CNS",
          "malignant lymphomas of the CNS",
          "microglioma",
          "primary CNS lymphoma",
          "primary brain lymphoma",
          "primary central nervous system lymphoma",
          "primary lymphoma, CNS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A non-Hodgkin or Hodgkin lymphoma that arises in the brain or spinal cord as a primary lesion. There is no evidence of lymphoma outside the central nervous system at the time of diagnosis."
      },
      "child_count": 18,
      "reference_id": "MONDO:0002571"
    },
    {
      "id": 4998,
      "label": "central nervous system germinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        4999,
        16619
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4438",
          "GARD:0023320",
          "MEDGEN:232242",
          "NCIT:C7009",
          "UMLS:C1333813"
        ],
        "synonyms": [
          "central nervous system germinoma",
          "central nervous system germinoma (disease)",
          "germinoma of CNS",
          "germinoma of central nervous system",
          "germinoma of the CNS",
          "germinoma of the central nervous system",
          "intracranial germinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor arising from the central nervous system. It is composed of uniform cells resembling primitive germ cells. These cells have large, vesicular nuclei, prominent nucleoli and a clear, glycogen-rich cytoplasm. Additional features are lymphoid or lymphoplasmacytic infiltrates and, less frequently, scattered syncytiotrophoblastic giant cells. (Adapted from WHO)"
      },
      "child_count": 9,
      "reference_id": "MONDO:0002999"
    },
    {
      "id": 5175,
      "label": "central nervous system melanocytic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4955",
          "GARD:0009422",
          "MEDGEN:1809168",
          "NCIT:C5504",
          "SCTID:277523004",
          "UMLS:C5670969"
        ],
        "synonyms": [
          "CNS melanocytic neoplasm",
          "CNS melanocytic tumor",
          "CNS melanocytic tumour",
          "central nervous system melanocytic neoplasm",
          "central nervous system melanocytic neoplasms",
          "central nervous system melanocytic tumor",
          "central nervous system melanocytic tumour",
          "melanocytic neoplasm of CNS",
          "melanocytic neoplasm of central nervous system",
          "melanocytic neoplasm of the CNS",
          "melanocytic neoplasm of the central nervous system",
          "melanocytic tumor of CNS",
          "melanocytic tumor of central nervous system",
          "melanocytic tumor of the central nervous system",
          "melanocytic tumour of CNS",
          "melanocytic tumour of central nervous system",
          "melanocytic tumour of the CNS",
          "melanocytic tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A primary tumor of the central nervous system that arises from leptomeningeal melanocytes. It may present as a diffuse proliferative leptomeningeal process (often as a component of the neurocutaneous melanosis complex) or as a distinct mass lesion."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003222"
    },
    {
      "id": 5333,
      "label": "central nervous system endodermal sinus tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        5332,
        5630,
        17189,
        20012
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5343",
          "GARD:0023501",
          "MEDGEN:234604",
          "NCIT:C6209",
          "UMLS:C1377613"
        ],
        "synonyms": [
          "central nervous system yolk Sac tumor",
          "central nervous system yolk Sac tumour",
          "central nervous system yolk sac tumor",
          "central nervous system yolk sac tumour",
          "childhood central nervous system yolk Sac neoplasm",
          "childhood central nervous system yolk Sac tumor",
          "childhood central nervous system yolk Sac tumour",
          "paediatric central nervous system yolk Sac neoplasm",
          "paediatric central nervous system yolk Sac tumour",
          "pediatric central nervous system yolk Sac neoplasm",
          "pediatric central nervous system yolk Sac tumor",
          "yolk Sac tumor of the CNS",
          "yolk Sac tumour of the CNS",
          "central nervous system endodermal sinus tumor",
          "childhood central nervous system endodermal sinus neoplasm",
          "childhood central nervous system endodermal sinus tumor",
          "childhood central nervous system endodermal sinus tumour",
          "paediatric central nervous system endodermal sinus neoplasm",
          "pediatric central nervous system endodermal sinus neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the central nervous system and occurs during childhood."
      },
      "child_count": 5,
      "reference_id": "MONDO:0003401"
    },
    {
      "id": 5449,
      "label": "spinal cord cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20444
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5612",
          "GARD:0027641",
          "ICD10CM:C72.0",
          "ICD9:192.2",
          "MEDGEN:56317",
          "NCIT:C3572",
          "SCTID:363475005",
          "UMLS:C0153646",
          "icd11.foundation:492029077"
        ],
        "synonyms": [
          "intraspinal tumor",
          "intraspinal tumour",
          "spinal cord neoplasm",
          "tumor of the spinal cord",
          "tumour of the spinal cord",
          "cancer of spinal cord",
          "malignant neoplasm of spinal cord",
          "malignant neoplasm of the spinal cord",
          "malignant spinal cord neoplasm",
          "malignant spinal cord tumor",
          "malignant spinal cord tumour",
          "malignant tumor of spinal cord",
          "malignant tumor of the spinal cord",
          "malignant tumour of spinal cord",
          "malignant tumour of the spinal cord",
          "spinal cord cancer",
          "spine cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the spinal cord. Representative examples include lymphoma, melanoma, and sarcoma."
      },
      "child_count": 16,
      "reference_id": "MONDO:0003544"
    },
    {
      "id": 6436,
      "label": "malignant carotid body paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4753,
        7266,
        20296,
        20310,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8731",
          "GARD:0024080",
          "ICD10CM:C75.4",
          "ICD9:194.5",
          "MEDGEN:56318",
          "NCIT:C3574",
          "SCTID:447883002",
          "UMLS:C0153656"
        ],
        "synonyms": [
          "carotid body paraganglioma, malignant",
          "malignant carotid body paraganglioma",
          "malignant carotid body tumor (morphologic abnormality)",
          "malignant carotid body tumour (morphologic abnormality)",
          "carotid body cancer",
          "chemodectoma, malignant",
          "malignant carotid body neoplasm",
          "malignant carotid body tumor",
          "malignant carotid body tumour",
          "malignant neoplasm of carotid body",
          "malignant neoplasm of the carotid body",
          "malignant tumor of carotid body",
          "malignant tumor of the carotid body",
          "malignant tumour of carotid body",
          "malignant tumour of the carotid body"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carotid body paraganglioma that metastasizes to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004650"
    },
    {
      "id": 7831,
      "label": "malignant adrenal gland pheochromocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4255,
        4753,
        6024,
        6716,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080347",
          "EFO:1000348",
          "GARD:0024362",
          "ICDO:8700/3",
          "MEDGEN:87238",
          "NCIT:C4220",
          "SCTID:21851000119103",
          "UMLS:C0334419"
        ],
        "synonyms": [
          "adrenal gland pheochromocytoma, malignant",
          "malignant adrenal gland Chromaffinoma",
          "malignant adrenal gland chromaffin neoplasm",
          "malignant adrenal gland chromaffin paraganglioma",
          "malignant adrenal gland chromaffin tumor",
          "malignant adrenal gland chromaffin tumour",
          "malignant adrenal gland paraganglioma",
          "malignant adrenal gland pheochromocytoma",
          "malignant adrenal medullary paraganglioma",
          "malignant adrenal medullary pheochromocytoma",
          "malignant adrenal pheochromocytoma",
          "malignant pheochromocytoma",
          "pheochromoblastoma",
          "pheochromocytoma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A pheochromocytoma that metastasizes to other anatomic sites. Common sites of metastasis include lymph nodes, bones, liver, and lung. Morphologic features associated with malignant pheochromocytomas include: atypical mitotic figures, capsular and vascular invasion, tumor cell necrosis, and high mitotic activity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006288"
    },
    {
      "id": 7833,
      "label": "malignant jugulotympanic paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4233,
        4265,
        4753,
        6420,
        20305,
        20310,
        20329,
        21452,
        23165
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024363",
          "MEDGEN:87584",
          "NCIT:C4623",
          "UMLS:C0347856"
        ],
        "synonyms": [
          "cancer of jugular body",
          "jugular body cancer",
          "malignant glomus jugulare neoplasm",
          "malignant glomus jugulare tumor",
          "malignant glomus jugulare tumour",
          "malignant jugular body neoplasm",
          "malignant jugulotympanic paraganglioma",
          "malignant neoplasm of glomus jugulare",
          "malignant neoplasm of jugular body",
          "malignant neoplasm of the glomus jugulare",
          "malignant tumor of glomus jugulare",
          "malignant tumor of the glomus jugulare",
          "malignant tumour of glomus jugulare",
          "malignant tumour of the glomus jugulare"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A jugulotympanic paraganglioma that metastasizes to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006291"
    },
    {
      "id": 12245,
      "label": "pheochromocytoma/paraganglioma syndrome 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        2912,
        4753,
        7836,
        17682,
        20310,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061217",
          "GARD:0010544",
          "MEDGEN:357076",
          "MESH:C566646",
          "OMIM:601650",
          "UMLS:C1866552"
        ],
        "synonyms": [
          "SDHAF2 paraganglioma",
          "SDHAF2-related tumor predisposition",
          "paraganglioma caused by mutation in SDHAF2",
          "paragangliomas 2",
          "paragangliomas type 2",
          "pheochromocytoma/paraganglioma syndrome 2",
          "PGL2",
          "SDHAF2-related hereditary paraganglioma-pheochromocytoma syndrome (paragangliomas 2)",
          "glomus tumors, familial, 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An autosomal dominant tumor predisposition disorder caused by pathogenic variants in the SDHAF2 gene, characterized by an increased risk of paraganglioma, particularly head and neck paragangliomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011121"
    },
    {
      "id": 14628,
      "label": "pheochromocytoma/paraganglioma syndrome 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2912,
        4753,
        7836,
        17682,
        20310,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061220",
          "GARD:0015763",
          "MEDGEN:481622",
          "OMIM:614165",
          "UMLS:C3279992"
        ],
        "synonyms": [
          "SDHA paraganglioma",
          "paraganglioma caused by mutation in SDHA",
          "paragangliomas 5",
          "paragangliomas type 5",
          "pheochromocytoma/paraganglioma syndrome 5",
          "PGL5"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any paraganglioma in which the cause of the disease is a mutation in the SDHA gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013602"
    },
    {
      "id": 17173,
      "label": "central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20283
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020718",
          "MEDGEN:1389430",
          "MedDRA:10057846",
          "NCIT:C129537",
          "Orphanet:251870",
          "UMLS:C4329632"
        ],
        "synonyms": [
          "central nervous system PNET",
          "central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor",
          "CNS PNET",
          "central nervous system primitive neuroectodermal tumor",
          "central nervous system primitive neuroectodermal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare Ewing sarcoma/peripheral primitive neuroectodermal tumor that affects the central nervous system either as a primary dural neoplasm or by direct extension from adjacent soft tissues or bone."
      },
      "child_count": 8,
      "reference_id": "MONDO:0016713"
    },
    {
      "id": 17190,
      "label": "choriocarcinoma of the central nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        5475,
        6924,
        20012
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020734",
          "MEDGEN:234100",
          "NCIT:C7012",
          "Orphanet:252015",
          "UMLS:C1332876",
          "icd11.foundation:511691786"
        ],
        "synonyms": [
          "central nervous system choriocarcinoma",
          "central nervous system choriocarcinoma (disease)",
          "choriocarcinoma of CNS",
          "choriocarcinoma of the CNS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor of the central nervous system characterized by extra-embryonic differentiation along trophoblastic lines. The diagnosis requires the identification of cytotrophoblastic elements, as well as syncytiotrophoblastic giant cells. (WHO)"
      },
      "child_count": 12,
      "reference_id": "MONDO:0016740"
    },
    {
      "id": 17191,
      "label": "mixed germ cell tumor of central nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2973,
        4753,
        4999
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020736",
          "MEDGEN:233713",
          "NCIT:C7016",
          "Orphanet:252021",
          "UMLS:C1334785"
        ],
        "synonyms": [
          "CNS mixed germ cell tumor",
          "CNS mixed germ cell tumour",
          "central nervous system mixed germ cell tumor",
          "central nervous system mixed germ cell tumour",
          "mixed germ cell neoplasm of the central nervous system",
          "mixed germ cell tumor of CNS",
          "mixed germ cell tumor of the CNS",
          "mixed germ cell tumor of the central nervous system",
          "mixed germ cell tumour of CNS",
          "mixed germ cell tumour of the CNS",
          "mixed germ cell tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor of the central nervous system characterized by the presence of at least two types of germ cell neoplasia."
      },
      "child_count": 6,
      "reference_id": "MONDO:0016742"
    },
    {
      "id": 18779,
      "label": "embryonal carcinoma of the central nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        7107,
        20012
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7232",
          "GARD:0018836",
          "MEDGEN:272566",
          "NCIT:C7010",
          "ONCOTREE:BEC",
          "Orphanet:48736",
          "UMLS:C1333377"
        ],
        "synonyms": [
          "central nervous system embryonal carcinoma",
          "embryonal carcinoma of CNS",
          "embryonal carcinoma of the CNS",
          "embryonal carcinoma of the central nervous system",
          "embryonal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A embryonal carcinoma that involves the central nervous system."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018843"
    },
    {
      "id": 20501,
      "label": "malignant tumor of meninges",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        17192
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025313",
          "ICD10CM:C70",
          "MEDGEN:87594",
          "NCIT:C4628",
          "SCTID:363497007",
          "UMLS:C0348375"
        ],
        "synonyms": [
          "cancer of meningeal cluster",
          "cancer of meninges",
          "cancer of the meninges",
          "malignant meningeal cluster neoplasm",
          "malignant meningeal neoplasms",
          "malignant meningeal tumor",
          "malignant meningeal tumour",
          "malignant meninges neoplasm",
          "malignant meninges tumor",
          "malignant meninges tumour",
          "malignant neoplasm of meningeal cluster",
          "malignant neoplasm of meninges",
          "malignant neoplasm of the meninges",
          "malignant neoplasms of meninges",
          "malignant tumor of the meninges",
          "malignant tumour of the meninges",
          "meningeal cancer",
          "meningeal cluster cancer",
          "meningeal tumors, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A cancer that involves the meningeal cluster."
      },
      "child_count": 20,
      "reference_id": "MONDO:0021322"
    },
    {
      "id": 22971,
      "label": "malignant central nervous system mesenchymal, non-meningothelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        5190,
        21548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027956",
          "MEDGEN:233147",
          "NCIT:C6758",
          "UMLS:C1334571"
        ],
        "synonyms": [
          "central nervous system mesenchymal non-meningothelial tumor, malignant",
          "malignant CNS soft tissue neoplasm",
          "malignant CNS soft tissue tumor",
          "malignant CNS soft tissue tumour",
          "malignant central nervous system mesenchymal non-meningothelial tumor",
          "malignant central nervous system mesenchymal non-meningothelial tumour",
          "malignant central nervous system mesenchymal, non-meningothelial neoplasm",
          "malignant central nervous system mesenchymal, non-meningothelial tumor",
          "malignant central nervous system mesenchymal, non-meningothelial tumour",
          "malignant central nervous system soft tissue neoplasm",
          "malignant central nervous system soft tissue tumor",
          "malignant central nervous system soft tissue tumour",
          "malignant soft tissue neoplasm of CNS",
          "malignant soft tissue neoplasm of central nervous system",
          "malignant soft tissue neoplasm of the CNS",
          "malignant soft tissue neoplasm of the central nervous system",
          "malignant soft tissue tumor of CNS",
          "malignant soft tissue tumor of central nervous system",
          "malignant soft tissue tumor of the CNS",
          "malignant soft tissue tumor of the central nervous system",
          "malignant soft tissue tumour of CNS",
          "malignant soft tissue tumour of central nervous system",
          "malignant soft tissue tumour of the CNS",
          "malignant soft tissue tumour of the central nervous system",
          "soft tissue cancer of central nervous system",
          "soft tissue cancer of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A metastasizing mesenchymal, non-meningothelial neoplasm that arises from the central nervous system."
      },
      "child_count": 9,
      "reference_id": "MONDO:0037740"
    },
    {
      "id": 24071,
      "label": "malignant glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20078,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3070",
          "GARD:0026148",
          "ICDO:9380/3",
          "MEDGEN:107826",
          "MedDRA:10018338",
          "NCIT:C4822",
          "UMLS:C0555198"
        ],
        "synonyms": [
          "glioma",
          "neuroglial tumor",
          "neuroglial tumour",
          "glial cell tumour",
          "glioma, malignant",
          "high grade glioma",
          "high-grade glioma",
          "malignant glial neoplasm",
          "malignant glial tumor",
          "malignant glial tumour",
          "malignant glioma",
          "malignant neuroglial neoplasm",
          "malignant neuroglial tumor",
          "malignant neuroglial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0100342"
    }
  ],
  "roots": [
    {
      "id": 7479,
      "label": "nervous system cancer"
    },
    {
      "id": 7694,
      "label": "central nervous system neoplasm"
    }
  ]
}