{
  "id": 4757,
  "label": "central nervous system teratoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002718",
  "properties": {
    "xrefs": [
      "DOID:3640",
      "GARD:0020735",
      "MEDGEN:234105",
      "NANDO:2200104",
      "NCIT:C5441",
      "Orphanet:252018",
      "UMLS:C1332895"
    ],
    "synonyms": [
      "CNS teratoma",
      "central nervous system teratoma",
      "teratoma of CNS",
      "teratoma of central nervous system",
      "teratoma of the CNS",
      "teratoma of the central nervous system"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A mature or immature teratoma that affects the central nervous system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 4656,
      "label": "teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3307",
          "GARD:0023184",
          "ICDO:9080/1",
          "MEDGEN:21097",
          "MESH:D013724",
          "NCIT:C3403",
          "ONCOTREE:TT",
          "SCTID:36591000119102",
          "UMLS:C0039538"
        ],
        "synonyms": [
          "teratoma"
        ],
        "definition": "A non-seminomatous germ cell tumor characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). It occurs in the testis, ovary, and extragonadal sites including central nervous system, mediastinum, lung, and stomach. According to the level of differentiation of the tissues which comprise the tumor, teratomas are classified as mature or immature. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal-type tissues. Testicular teratomas in children follow a benign clinical course. Mature ovarian teratomas without a fetal-type component have an excellent outcome. The prognosis of immature ovarian teratomas is related to the grade and stage of the tumor."
      },
      "child_count": 13,
      "reference_id": "MONDO:0002601"
    },
    {
      "id": 19318,
      "label": "extragonadal teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018711",
          "MEDGEN:1646497",
          "MedDRA:10043276",
          "NCIT:C189045",
          "Orphanet:883",
          "SCTID:768937006",
          "UMLS:C4708601"
        ],
        "definition": "Extragonadal teratoma is an extremely rare, benign or malignant germ cell tumor characterized, clinically, by a teratoma presenting in an extragonadal location (e.g. retroperitoneum, mediastinum, craniofacial or sacrococcygeal region, intraosseous, solid organs) and, histologically, by displaying well-differentiated structures, as well as immature elements. Presenting symptoms are variable depending on size and location of tumor."
      },
      "child_count": 3,
      "reference_id": "MONDO:0019500"
    },
    {
      "id": 20012,
      "label": "central nervous system nongerminomatous germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4999,
        19983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025171",
          "MEDGEN:760465",
          "NCIT:C100093",
          "UMLS:C1696109"
        ],
        "synonyms": [
          "central nervous system nongerminomatous germ cell tumor",
          "nongerminomatous GCT - CNS",
          "nongerminomatous germ cell tumor of the CNS",
          "nongerminomatous germ cell tumour of the CNS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Germ cell tumors of the central nervous system other than germinoma. This category includes teratoma, choriocarcinoma, embryonal carcinoma, and yolk sac tumor."
      },
      "child_count": 8,
      "reference_id": "MONDO:0020574"
    }
  ],
  "children": [
    {
      "id": 4756,
      "label": "spinal cord intramedullary teratoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4757,
        20625
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3639",
          "GARD:0023220",
          "MEDGEN:233575",
          "NCIT:C5428",
          "UMLS:C1334259"
        ],
        "synonyms": [
          "intramedullary spinal cord teratoma",
          "intramedullary spinal teratoma",
          "intramedullary teratoma of spinal cord",
          "intramedullary teratoma of the spinal cord"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0002717"
    },
    {
      "id": 5611,
      "label": "adult central nervous system teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4757,
        5337,
        5429
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6015",
          "GARD:0023636",
          "MEDGEN:234583",
          "NCIT:C5794",
          "UMLS:C1370506"
        ],
        "synonyms": [
          "Central nervous system teratoma",
          "adult CNS teratoma",
          "adult central nervous system teratoma",
          "central nervous system teratoma of adults",
          "teratoma of adult CNS",
          "teratoma of adult central nervous system",
          "teratoma of the adult CNS",
          "teratoma of the adult central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A mature or immature teratoma affecting the central nervous system and occurring in adults."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003731"
    },
    {
      "id": 5613,
      "label": "central nervous system mature teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4757,
        5430
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6017",
          "GARD:0023638",
          "MEDGEN:234103",
          "NCIT:C7013",
          "ONCOTREE:BMT",
          "UMLS:C1332886"
        ],
        "synonyms": [
          "CNS mature teratoma",
          "central nervous system mature teratoma",
          "mature teratoma of CNS",
          "mature teratoma of central nervous system",
          "mature teratoma of the CNS",
          "mature teratoma of the central nervous system",
          "mature teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A teratoma composed exclusively of fully differentiated, 'adult-type' tissue elements that are sometimes arranged in a pattern resembling normal tissue relationships. Mitotic activity is low or absent. The more common ectodermal components present in a mature teratoma include skin, brain and choroid plexus. The more common mesodermal components include cartilage, bone, fat and muscle (both smooth and striated). And the most common endodermal components are cysts lined by epithelia of respiratory or enteric type and in some cases pancreatic or hepatic tissue. (Adapted from WHO)"
      },
      "child_count": 6,
      "reference_id": "MONDO:0003733"
    },
    {
      "id": 5615,
      "label": "central nervous system immature teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4757
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6019",
          "GARD:0023640",
          "MEDGEN:272442",
          "NCIT:C7014",
          "ONCOTREE:BIMT",
          "UMLS:C1332883"
        ],
        "synonyms": [
          "CNS immature teratoma",
          "central nervous system immature teratoma",
          "immature teratoma of CNS",
          "immature teratoma of central nervous system",
          "immature teratoma of the CNS",
          "immature teratoma of the central nervous system",
          "immature teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A variant of teratoma composed of incompletely differentiated components resembling fetal tissues. Even if the immature component is only a minor element of an otherwise differentiated teratoma, the tumor is still classified as immature. (Adapted from WHO)"
      },
      "child_count": 3,
      "reference_id": "MONDO:0003735"
    },
    {
      "id": 5864,
      "label": "pineal region teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4757,
        20442
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6856",
          "GARD:0023777",
          "MEDGEN:277517",
          "NCIT:C6753",
          "UMLS:C1335419"
        ],
        "synonyms": [
          "pineal area teratoma",
          "teratoma of pineal area",
          "teratoma of pineal region",
          "teratoma of the pineal area",
          "teratoma of the pineal region"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A mature or immature teratoma that arises in the pineal region."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004015"
    },
    {
      "id": 5931,
      "label": "spinal cord dermoid cyst",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4475,
        4757,
        20444
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7071",
          "GARD:0023818",
          "MEDGEN:232125",
          "NCIT:C6808",
          "UMLS:C1333278"
        ],
        "synonyms": [
          "dermoid cyst of spinal cord",
          "dermoid cyst of the spinal cord",
          "spinal cord dermoid",
          "spinal cord dermoid cyst"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A dermoid cyst that involves the spinal cord."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004096"
    }
  ],
  "roots": [
    {
      "id": 4656,
      "label": "teratoma"
    },
    {
      "id": 19318,
      "label": "extragonadal teratoma"
    },
    {
      "id": 20012,
      "label": "central nervous system nongerminomatous germ cell tumor"
    }
  ]
}