{
  "id": 4762,
  "label": "mast cell neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002724",
  "properties": {
    "xrefs": [
      "DOID:3664",
      "EFO:0009000",
      "GARD:0023222",
      "ICD9:238.79",
      "MEDGEN:83178",
      "NCIT:C9295",
      "SCTID:414653009",
      "UMLS:C0334664"
    ],
    "synonyms": [
      "Mast cell proliferative disease",
      "Mast cell tumor",
      "Mast cell tumour",
      "mast cell neoplasm",
      "mast cell tumor",
      "mast cell tumour",
      "neoplasm of Mast cells",
      "neoplasm of the Mast cells",
      "tumor of Mast cells",
      "tumor of the Mast cells",
      "tumour of Mast cells",
      "tumour of the Mast cells"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A heterogeneous group of disorders characterized by the abnormal growth and accumulation of mast cells in one or more organ systems. Recent data suggest that most variants of mast cell neoplasms are clonal disorders. (WHO, 2001)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6892,
      "label": "myeloid neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070004",
          "EFO:0002427",
          "GARD:0024160",
          "ICDO:9975/1",
          "MEDGEN:445430",
          "NCIT:C9290",
          "ONCOTREE:MYELOID",
          "UMLS:C2939461"
        ],
        "synonyms": [
          "myeloid malignancy",
          "myeloid neoplasm",
          "myeloid tumor",
          "myeloid tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Proliferation of myeloid cells originating from a primitive stem cell."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005170"
    }
  ],
  "children": [
    {
      "id": 5066,
      "label": "mastocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0023358",
          "ICD9:238.5",
          "ICDO:9740/1",
          "MEDGEN:6237",
          "MESH:D034801",
          "NCIT:C9303",
          "SCTID:404171008",
          "UMLS:C0024897"
        ],
        "synonyms": [
          "mastocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A localized tumor composed of sheets of mast cells without atypia. It includes the cutaneous mastocytoma which involves the dermis and subcutaneous tissue, and the extracutaneous mastocytoma. Most cases of extracutaneous mastocytoma have been reported in the lung."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003079"
    },
    {
      "id": 9280,
      "label": "mastocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4762,
        6569
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:350",
          "EFO:0009001",
          "GARD:0006987",
          "ICD10WHO:Q82.2",
          "MEDGEN:9902",
          "MESH:D008415",
          "MedDRA:10026891",
          "NCIT:C84269",
          "NORD:1408",
          "ONCOTREE:MCD",
          "Orphanet:98292",
          "UMLS:C0024899",
          "icd11.foundation:691643472"
        ],
        "synonyms": [
          "Mast cell disease",
          "mastocytosis",
          "MAST cell disease",
          "urticaria pigmentosa"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal myeloproliferative neoplasm characterized by the proliferation and accumulation of neoplastic mast cells in one or multiple organs or organ systems. It is a heterogeneous group of neoplasms, ranging from cutaneous proliferations which may regress spontaneously, to aggressive neoplasms associated with organ failure and short survival."
      },
      "child_count": 10,
      "reference_id": "MONDO:0007950"
    }
  ],
  "roots": [
    {
      "id": 6892,
      "label": "myeloid neoplasm"
    }
  ]
}