{
  "id": 4771,
  "label": "anal canal adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002735",
  "properties": {
    "xrefs": [
      "DOID:3692",
      "GARD:0021773",
      "HP:0030439",
      "MEDGEN:233977",
      "NCIT:C7471",
      "Orphanet:424016",
      "SCTID:764845008",
      "UMLS:C1332259",
      "icd11.foundation:168138050"
    ],
    "synonyms": [
      "adenocarcinoma arising in anal mucosa",
      "adenocarcinoma arising in the anal mucosa",
      "adenocarcinoma of anal canal",
      "adenocarcinoma of the anal canal",
      "anal canal adenocarcinoma",
      "anal canal adenocarcinoma (disease)"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "An anal adenocarcinoma arising from the anal canal mucosa. Morphologically, it resembles the adenocarcinoma which arises from the colorectal glandular epithelium. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4703,
      "label": "anus adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4295,
        5158
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3447",
          "GARD:0027609",
          "MEDGEN:233976",
          "NCIT:C5600",
          "SCTID:423607006",
          "UMLS:C1332257"
        ],
        "synonyms": [
          "adenocarcinoma of anus",
          "adenocarcinoma of the anus",
          "anal adenocarcinoma",
          "anus adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising in the anal canal epithelium, including the mucosal surface, the anal glands, and the lining of fistulous tracts. The prognosis is related to the stage at diagnosis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002652"
    },
    {
      "id": 8521,
      "label": "anal canal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2895,
        5158,
        18546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6126",
          "GARD:0021772",
          "MEDGEN:107559",
          "NCIT:C7489",
          "OMIM:105580",
          "Orphanet:424013",
          "SCTID:285310000",
          "UMLS:C0563211"
        ],
        "synonyms": [
          "anal canal cancer",
          "anal canal and perianal gland cancer",
          "anal canal and perianal gland carcinoma",
          "anal canal carcinoma",
          "carcinoma of anal canal",
          "carcinoma of the anal canal",
          "cloacogenic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the anal canal"
      },
      "child_count": 15,
      "reference_id": "MONDO:0007108"
    }
  ],
  "children": [
    {
      "id": 6274,
      "label": "anal canal Paget disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4702,
        4771
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8119",
          "GARD:0024022",
          "MEDGEN:231062",
          "NCIT:C7477",
          "SCTID:236811000119101",
          "UMLS:C1332261"
        ],
        "synonyms": [
          "Paget disease of the anal canal",
          "Paget's disease of anal canal",
          "Paget's disease of the anal canal",
          "anal canal Paget disease",
          "anal canal Paget's disease",
          "anal canal mammary Paget's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Paget disease involving the squamous epithelium of the anal canal."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004468"
    }
  ],
  "roots": [
    {
      "id": 4703,
      "label": "anus adenocarcinoma"
    },
    {
      "id": 8521,
      "label": "anal canal carcinoma"
    }
  ]
}