{
  "id": 4787,
  "label": "ovarian adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002752",
  "properties": {
    "xrefs": [
      "DOID:3713",
      "EFO:0006460",
      "GARD:0020466",
      "MEDGEN:181757",
      "MedDRA:10051938",
      "NCIT:C7700",
      "Orphanet:213504",
      "UMLS:C0948216"
    ],
    "synonyms": [
      "adenocarcinoma of ovary",
      "adenocarcinoma of the ovary",
      "ovarian adenocarcinoma",
      "ovary adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An adenocarcinoma that arises from the ovary. It is the most common type of ovarian carcinoma. It includes the serous adenocarcinoma, mucinous adenocarcinoma, clear cell adenocarcinoma, and endometrioid adenocarcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 6864,
      "label": "ovarian carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4001",
          "EFO:0001075",
          "GARD:0024154",
          "MEDGEN:1648335",
          "NCIT:C4908",
          "UMLS:C4721610"
        ],
        "synonyms": [
          "ovarian cancer",
          "ovarian epithelial cancer",
          "carcinoma of ovary",
          "carcinoma of the ovary",
          "epithelial ovarian cancer",
          "ovarian carcinoma",
          "ovary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002"
      },
      "child_count": 9,
      "reference_id": "MONDO:0005140"
    }
  ],
  "children": [
    {
      "id": 4744,
      "label": "ovarian cystadenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4787,
        7240
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3605",
          "EFO:1001962",
          "GARD:0023217",
          "MEDGEN:242756",
          "NCIT:C5228",
          "SCTID:314191009",
          "UMLS:C1096638"
        ],
        "synonyms": [
          "cystadenocarcinoma of ovary",
          "cystadenocarcinoma of the ovary",
          "ovarian cystadenocarcinoma",
          "ovary cystadenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the ovary and is characterized by the presence of cystic structures. It includes the serous cystadenocarcinoma, mucinous cystadenocarcinoma, and clear cell cystadenocarcinoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002702"
    },
    {
      "id": 5150,
      "label": "rete ovarii adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4787,
        5151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4894",
          "GARD:0023405",
          "MEDGEN:826068",
          "NCIT:C40017",
          "UMLS:C3840223"
        ],
        "synonyms": [
          "rete ovarii adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An exceptionally rare adenocarcinoma that arises from the rete ovarii."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003191"
    },
    {
      "id": 6587,
      "label": "Krukenberg carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4787,
        6819,
        21603
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9597",
          "EFO:1000316",
          "GARD:0008627",
          "MEDGEN:9652",
          "MESH:D007725",
          "NCIT:C3153",
          "SCTID:359987004",
          "UMLS:C0022790"
        ],
        "synonyms": [
          "Krukenberg neoplasm",
          "Krukenberg tumor",
          "Krukenberg tumour",
          "Krukenberg’s tumor",
          "Krukenberg’s tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Metastatic signet-ring cell carcinoma to the ovary. The primary site is the gastrointestinal tract or breast."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004829"
    },
    {
      "id": 6927,
      "label": "ovarian serous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4787,
        6974,
        21609
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050933",
          "DOID:5744",
          "EFO:0002917",
          "GARD:0024164",
          "MEDGEN:233278",
          "NCIT:C7550",
          "ONCOTREE:SOC",
          "UMLS:C1335177"
        ],
        "synonyms": [
          "ovarian serous adenocarcinoma",
          "ovarian serous carcinoma",
          "ovary serous adenocarcinoma",
          "serous adenocarcinoma of ovary",
          "serous adenocarcinoma of the ovary",
          "serous carcinoma of ovary",
          "serous carcinoma of the ovary",
          "malignant ovarian serous tumour",
          "serous ovarian cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that, in well differentiated tumors, resemble the epithelium of the fallopian tube or, in poorly differentiated tumors, show anaplastic features and marked nuclear atypia."
      },
      "child_count": 9,
      "reference_id": "MONDO:0005211"
    },
    {
      "id": 7244,
      "label": "ovarian mucinous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4787,
        6700,
        21318
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3606",
          "EFO:0006462",
          "GARD:0021651",
          "MEDGEN:235418",
          "NCIT:C5243",
          "Orphanet:398961",
          "UMLS:C1335167",
          "icd11.foundation:869438441"
        ],
        "synonyms": [
          "mucinous adenocarcinoma of ovary",
          "mucinous adenocarcinoma of the ovary",
          "mucinous carcinoma of ovary",
          "mucinous carcinoma of the ovary",
          "ovarian mucinous adenocarcinoma",
          "ovarian mucinous carcinoma",
          "ovary mucinous adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An invasive adenocarcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that contain intracytoplasmic mucin. There is cellular atypia, increased layering of cells, complexity of glands, and papillary formations."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005601"
    },
    {
      "id": 7631,
      "label": "ovarian clear cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2987,
        4787,
        6742
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5304",
          "EFO:1000042",
          "GARD:0021652",
          "MEDGEN:276659",
          "NCIT:C40078",
          "Orphanet:398971",
          "SCTID:763131005",
          "UMLS:C1518693",
          "icd11.foundation:315825558"
        ],
        "synonyms": [
          "clear cell adenocarcinoma of ovary",
          "ovarian clear cell adenocarcinoma",
          "ovary clear cell adenocarcinoma",
          "clear cell adenocarcinoma of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant glandular epithelial neoplasm characterized by the presence of clear and hobnail cells. It is highly associated with ovarian endometriosis, pelvic endometriosis and paraendocrine hypercalcemia."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006045"
    },
    {
      "id": 7864,
      "label": "ovarian endometrioid adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4787,
        5685,
        6760,
        7120
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5828",
          "EFO:1000416",
          "GARD:0021893",
          "MEDGEN:91087",
          "NCIT:C7979",
          "ONCOTREE:EOV",
          "Orphanet:454723",
          "SCTID:254852002",
          "UMLS:C0346163"
        ],
        "synonyms": [
          "endometrioid adenocarcinoma of ovary",
          "endometrioid adenocarcinoma of the ovary",
          "endometrioid cancer of ovary",
          "endometrioid cancer of the ovary",
          "endometrioid carcinoma of ovary",
          "endometrioid carcinoma of the ovary",
          "endometrioid ovary carcinoma",
          "endometrium adenocarcinoma of ovary",
          "ovarian endometrioid adenocarcinoma",
          "ovarian endometrioid cancer",
          "ovarian endometrioid carcinoma",
          "ovary endometrium adenocarcinoma",
          "endometrioid ovarian cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An endometrioid adenocarcinoma arising from the ovary. It comprises 10% to 25% of all primary ovarian carcinomas. Grossly, endometrioid carcinoma may present as a cystic or solid mass. Microscopically, the tumor greatly resembles the appearance of the ordinary type of endometrial adenocarcinoma. As a group, endometrioid carcinoma has a prognosis twice as good as that of serous or mucinous carcinoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006335"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 6864,
      "label": "ovarian carcinoma"
    }
  ]
}