{
  "id": 4792,
  "label": "vulva verrucous carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002758",
  "properties": {
    "xrefs": [
      "DOID:3740",
      "GARD:0023236",
      "MEDGEN:234482",
      "NCIT:C6383",
      "UMLS:C1336983"
    ],
    "synonyms": [
      "mammalian vulva verrucous carcinoma",
      "verrucous carcinoma of the vulva",
      "verrucous carcinoma of vulva",
      "vulvar verrucous carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A highly differentiated squamous cell carcinoma that arises from the vulva. It is characterized by the presence of a warty and hyperkeratinized surface, malignant cells with abundant eosinophilic cytoplasm, minimal cytologic atypia, and absence or rarity of mitotic figures. The tumor infiltrates the underlying stroma with a pushing border."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7597,
      "label": "verrucous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3737",
          "EFO:0007535",
          "ICD9:199.1",
          "ICDO:8051/3",
          "MEDGEN:60213",
          "MESH:D018289",
          "NCIT:C3781",
          "SCTID:403904009",
          "UMLS:C0206706"
        ],
        "synonyms": [
          "verrucous carcinoma",
          "verrucous carcinoma NOS (morphologic abnormality)",
          "verrucous epidermoid carcinoma",
          "verrucous epidermoid cell carcinoma",
          "verrucous squamous carcinoma",
          "verrucous squamous cell carcinoma",
          "warty carcinoma"
        ],
        "definition": "A well differentiated squamous cell carcinoma characterized by a papillary growth pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, esophagus, anus, vagina, vulva, and the plantar region of the foot."
      },
      "child_count": 10,
      "reference_id": "MONDO:0006006"
    },
    {
      "id": 21524,
      "label": "vulvar squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4318,
        6823,
        6931
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2101",
          "EFO:1000624",
          "GARD:0022005",
          "MEDGEN:79201",
          "NCIT:C4052",
          "Orphanet:494448",
          "SCTID:254895003",
          "UMLS:C0280856",
          "icd11.foundation:146824338"
        ],
        "synonyms": [
          "epidermoid carcinoma of the vulva",
          "epidermoid carcinoma of vulva",
          "epidermoid cell carcinoma of the vulva",
          "epidermoid cell carcinoma of vulva",
          "mammalian vulva squamous cell carcinoma",
          "squamous cell carcinoma of the vulva",
          "squamous cell carcinoma of vulva",
          "vulva epidermoid carcinoma",
          "vulva epidermoid cell carcinoma",
          "vulva squamous cell carcinoma",
          "vulvar epidermoid carcinoma",
          "vulvar epidermoid cell carcinoma",
          "vulvar squamous cell cancer",
          "vulvar squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An invasive squamous cell carcinoma arising from the vulva. Risk factors include the human papilloma virus and cigarette smoking. Precursor lesions include the vulvar intraepithelial neoplasia, lichen sclerosus with associated squamous cell hyperplasia, and chronic granulomatous vulvar disease such as granuloma inguinale. Symptoms include vulvar pruritus or irritation, discharge, bleeding, and pain. The following morphologic variants have been identified: keratinizing, non-keratinizing, basaloid, warty, verrucous, keratoacanthoma-like, and squamous cell carcinoma with tumor giant cells. Risk factors for recurrence include advanced stage, tumor diameter greater than 2.5 cm, multifocality, capillary-like space involvement, associated vulvar intraepithelial neoplasia grades 2 or 3, and margins of resection involved by tumor. (WHO, 2003)"
      },
      "child_count": 18,
      "reference_id": "MONDO:0024609"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7597,
      "label": "verrucous carcinoma"
    },
    {
      "id": 21524,
      "label": "vulvar squamous cell carcinoma"
    }
  ]
}