{
  "id": 4794,
  "label": "bladder squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002760",
  "properties": {
    "xrefs": [
      "DOID:3742",
      "EFO:1000130",
      "MEDGEN:124645",
      "NCIT:C4031",
      "ONCOTREE:BLSC",
      "SCTID:255111004",
      "UMLS:C0279681"
    ],
    "synonyms": [
      "bladder epidermoid carcinoma",
      "bladder squamous cell cancer",
      "bladder squamous cell carcinoma",
      "epidermoid carcinoma of bladder",
      "epidermoid carcinoma of the bladder",
      "epidermoid carcinoma of the urinary bladder",
      "epidermoid carcinoma of urinary bladder",
      "squamous cell carcinoma of bladder",
      "squamous cell carcinoma of the bladder",
      "squamous cell carcinoma of the urinary bladder",
      "squamous cell carcinoma of urinary bladder",
      "urinary bladder epidermoid carcinoma",
      "urinary bladder squamous cell carcinoma",
      "BLSC"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A squamous cell carcinoma of the bladder arising from metaplastic epithelium. It represents less than 10% of bladder carcinomas. The exception is the Middle East along the Nile Valley, where it represents the most common form of carcinoma because of the endemic nature of schistosomiasis. Bladder squamous cell carcinoma is often associated with long-standing chronic inflammation of the bladder and usually has a poor prognosis. The diagnosis of squamous cell carcinoma of the bladder should be reserved for those tumors that are predominantly keratin forming."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6727,
      "label": "urinary bladder carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3431,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4007",
          "HP:0002862",
          "MEDGEN:147071",
          "NCIT:C4912",
          "SCTID:255108000",
          "UMLS:C0699885"
        ],
        "synonyms": [
          "bladder cancer",
          "cancer of bladder",
          "cancer of the bladder",
          "cancer of the urinary bladder",
          "cancer of urinary bladder",
          "urinary bladder cancer",
          "bladder carcinoma",
          "carcinoma bladder",
          "carcinoma of bladder",
          "carcinoma of the bladder",
          "carcinoma of the urinary bladder",
          "carcinoma of urinary bladder",
          "urinary bladder carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the urinary bladder"
      },
      "child_count": 18,
      "reference_id": "MONDO:0004986"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    }
  ],
  "children": [
    {
      "id": 4793,
      "label": "bladder verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4794,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3741",
          "MEDGEN:267376",
          "NCIT:C39832",
          "UMLS:C1511208"
        ],
        "synonyms": [
          "bladder verrucous carcinoma",
          "bladder verrucous squamous cell carcinoma",
          "urinary bladder verrucous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A verrucous carcinoma that involves the urinary bladder."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002759"
    },
    {
      "id": 5595,
      "label": "bladder urachal squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4794,
        5596
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5957",
          "MEDGEN:307289",
          "NCIT:C39845",
          "UMLS:C1511206"
        ],
        "synonyms": [
          "bladder urachal squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0003714"
    }
  ],
  "roots": [
    {
      "id": 6727,
      "label": "urinary bladder carcinoma"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    }
  ]
}