{
  "id": 4795,
  "label": "cervical verrucous carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002761",
  "properties": {
    "xrefs": [
      "DOID:3743",
      "GARD:0023237",
      "MEDGEN:275713",
      "NCIT:C40190",
      "UMLS:C1516435"
    ],
    "synonyms": [
      "cervical verrucous carcinoma",
      "uterine cervix verrucous carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A highly differentiated variant of cervical squamous cell carcinoma characterized by the presence of a warty surface and stromal invasion with pushing borders. The malignant cells have abundant cytoplasm and minimal nuclear atypia. Koilocytosis is not present."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7597,
      "label": "verrucous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3737",
          "EFO:0007535",
          "ICD9:199.1",
          "ICDO:8051/3",
          "MEDGEN:60213",
          "MESH:D018289",
          "NCIT:C3781",
          "SCTID:403904009",
          "UMLS:C0206706"
        ],
        "synonyms": [
          "verrucous carcinoma",
          "verrucous carcinoma NOS (morphologic abnormality)",
          "verrucous epidermoid carcinoma",
          "verrucous epidermoid cell carcinoma",
          "verrucous squamous carcinoma",
          "verrucous squamous cell carcinoma",
          "warty carcinoma"
        ],
        "definition": "A well differentiated squamous cell carcinoma characterized by a papillary growth pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, esophagus, anus, vagina, vulva, and the plantar region of the foot."
      },
      "child_count": 10,
      "reference_id": "MONDO:0006006"
    },
    {
      "id": 7706,
      "label": "cervical squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        6855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3744",
          "EFO:1000172",
          "GARD:0020487",
          "MEDGEN:124644",
          "NCIT:C4028",
          "ONCOTREE:CESC",
          "Orphanet:213767",
          "SCTID:254886006",
          "UMLS:C0279671",
          "icd11.foundation:1544785014"
        ],
        "synonyms": [
          "cervical squamous cell cancer",
          "cervical squamous cell carcinoma",
          "cervix squamous cell carcinoma",
          "cervix uteri squamous cell carcinoma",
          "squamous cell carcinoma of cervix",
          "squamous cell carcinoma of cervix uteri",
          "squamous cell carcinoma of the cervix",
          "squamous cell carcinoma of the cervix uteri",
          "squamous cell carcinoma of the uterine cervix",
          "squamous cell carcinoma of uterine cervix",
          "squamous cervical cancer",
          "uterine cervix squamous cell carcinoma",
          "CESC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. The following histologic patterns have been described: conventional squamous cell carcinoma, papillary squamous cell carcinoma, transitional cell carcinoma, lymphoepithelioma-like carcinoma, verrucous carcinoma, condylomatous carcinoma and spindle cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis."
      },
      "child_count": 14,
      "reference_id": "MONDO:0006143"
    },
    {
      "id": 16844,
      "label": "papillary carcinoma of the cervix uteri",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6855,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020497",
          "Orphanet:213817"
        ],
        "synonyms": [
          "cervical papillary carcinoma",
          "uterine cervix papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A papillary carcinoma that involves the uterine cervix."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016285"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7597,
      "label": "verrucous carcinoma"
    },
    {
      "id": 7706,
      "label": "cervical squamous cell carcinoma"
    },
    {
      "id": 16844,
      "label": "papillary carcinoma of the cervix uteri"
    }
  ]
}