{
  "id": 4800,
  "label": "larynx verrucous carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002766",
  "properties": {
    "xrefs": [
      "DOID:3752",
      "GARD:0023239",
      "MEDGEN:76097",
      "NCIT:C8188",
      "SCTID:707427000",
      "UMLS:C0280328"
    ],
    "synonyms": [
      "laryngeal throat verrucous cancer",
      "laryngeal verrucous carcinoma",
      "larynx verrucous carcinoma",
      "verrucous carcinoma of larynx",
      "verrucous carcinoma of the larynx"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A well differentaited, non-metastasizing squamous cell carcinoma arising from the larynx. It is an exophytic, warty, and slow growing tumor affecting predominantly older men. It is associated with tobacco smoking. Symptoms include hoarseness, airway obstruction, weight loss, dysphagia, and throat pain. If left untreated, it may cause extensive local destruction."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7239,
      "label": "laryngeal squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4457,
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2876",
          "EFO:0006352",
          "GARD:0017908",
          "MEDGEN:83630",
          "NCIT:C4044",
          "ONCOTREE:LXSC",
          "Orphanet:494550",
          "SCTID:405822008",
          "UMLS:C0280324"
        ],
        "synonyms": [
          "epidermoid carcinoma of larynx",
          "epidermoid carcinoma of the larynx",
          "laryngeal epidermoid carcinoma",
          "laryngeal squamous cell carcinoma",
          "laryngeal throat squamous cell cancer",
          "larynx epidermoid carcinoma",
          "larynx squamous cell carcinoma",
          "squamous cell carcinoma of larynx",
          "squamous cell carcinoma of the larynx",
          "LXSC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the larynx. It is the most common histologic type of laryngeal carcinoma. It can arise from the glottis, supraglottic area, or it can be transglottic. Glottic squamous cell carcinoma is the most frequent laryngeal carcinoma in the United States. The symptoms, clinical behavior and the prognosis depend on the site of origin within the larynx."
      },
      "child_count": 8,
      "reference_id": "MONDO:0005595"
    },
    {
      "id": 7597,
      "label": "verrucous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3737",
          "EFO:0007535",
          "ICD9:199.1",
          "ICDO:8051/3",
          "MEDGEN:60213",
          "MESH:D018289",
          "NCIT:C3781",
          "SCTID:403904009",
          "UMLS:C0206706"
        ],
        "synonyms": [
          "verrucous carcinoma",
          "verrucous carcinoma NOS (morphologic abnormality)",
          "verrucous epidermoid carcinoma",
          "verrucous epidermoid cell carcinoma",
          "verrucous squamous carcinoma",
          "verrucous squamous cell carcinoma",
          "warty carcinoma"
        ],
        "definition": "A well differentiated squamous cell carcinoma characterized by a papillary growth pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, esophagus, anus, vagina, vulva, and the plantar region of the foot."
      },
      "child_count": 10,
      "reference_id": "MONDO:0006006"
    }
  ],
  "children": [
    {
      "id": 6106,
      "label": "glottis verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4800,
        5916
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7583",
          "GARD:0023912",
          "MEDGEN:83631",
          "NCIT:C8189",
          "UMLS:C0280329"
        ],
        "synonyms": [
          "glottic verrucous carcinoma",
          "glottis verrucous carcinoma",
          "verrucous carcinoma of glottis",
          "verrucous carcinoma of the glottis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An exophytic, slow growing, well differentiated and non-metastasizing squamous cell carcinoma with pushing margins that arises from the glottic area of the larynx. It usually presents with hoarseness."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004289"
    },
    {
      "id": 6107,
      "label": "subglottis verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4800,
        6108
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7584",
          "GARD:0023913",
          "MEDGEN:124721",
          "NCIT:C8190",
          "UMLS:C0280330"
        ],
        "synonyms": [
          "subglottic verrucous carcinoma",
          "subglottis verrucous carcinoma",
          "verrucous carcinoma of subglottis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An exophytic, slow growing, well differentiated and non-metastasizing squamous cell carcinoma with pushing margins that arises from the subglottic area of the larynx."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004290"
    },
    {
      "id": 6109,
      "label": "supraglottis verrucous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4800,
        6110
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7586",
          "GARD:0023915",
          "MEDGEN:76098",
          "NCIT:C8191",
          "UMLS:C0280331"
        ],
        "synonyms": [
          "supraglottic part of larynx verrucous carcinoma",
          "supraglottic verrucous carcinoma",
          "supraglottis verrucous carcinoma",
          "verrucous carcinoma of supraglottis",
          "verrucous carcinoma of the supraglottis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An exophytic, slow growing, well differentiated and non-metastasizing squamous cell carcinoma with pushing margins that arises from the supraglottic area of the larynx."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004292"
    }
  ],
  "roots": [
    {
      "id": 7239,
      "label": "laryngeal squamous cell carcinoma"
    },
    {
      "id": 7597,
      "label": "verrucous carcinoma"
    }
  ]
}