{
  "id": 4812,
  "label": "Shwartzman phenomenon",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002783",
  "properties": {
    "xrefs": [
      "DOID:3825",
      "GARD:0007636",
      "MEDGEN:48656",
      "MESH:D012790",
      "UMLS:C0037018"
    ],
    "synonyms": [
      "Shwartzman reaction (function)"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (endotoxins) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous thrombosis and necrosis. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of immune system, coagulation, fibrinolysis, and blood flow."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5128,
      "label": "vascular hemostatic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4360,
        7065
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:484",
          "GARD:0023389",
          "MEDGEN:154721",
          "MESH:D020141",
          "SCTID:21112004",
          "UMLS:C0600502"
        ],
        "synonyms": [
          "disorder, vascular hemostatic",
          "disorders, vascular hemostatic",
          "hemostatic disorder",
          "hemostatic disorder, vascular",
          "hemostatic disorders, vascular",
          "vascular hemostatic disorder",
          "vascular hemostatic disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of blood vessels, blood fluidity, and blood coagulation. Majority of the hemostatic disorders are caused by disruption of the normal interaction between the vascular endothelium, the plasma proteins (including blood coagulation factors), and platelets."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003159"
    },
    {
      "id": 18813,
      "label": "vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7065,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:865",
          "EFO:0006803",
          "GARD:0018844",
          "MEDGEN:12054",
          "MESH:D014657",
          "MedDRA:10036023",
          "MedDRA:10047115",
          "NCIT:C26912",
          "Orphanet:52759",
          "SCTID:31996006",
          "UMLS:C0042384",
          "Wikipedia:Vasculitis",
          "icd11.foundation:572581721"
        ],
        "synonyms": [
          "systemic vasculitis",
          "angiitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behcet disease) to relatively minor skin disease."
      },
      "child_count": 36,
      "reference_id": "MONDO:0018882"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5128,
      "label": "vascular hemostatic disease"
    },
    {
      "id": 18813,
      "label": "vasculitis"
    }
  ]
}