{
  "id": 4829,
  "label": "intestinal pseudo-obstruction",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002803",
  "properties": {
    "xrefs": [
      "DOID:3878",
      "GARD:0006789",
      "ICD9:569.89",
      "MEDGEN:5864",
      "MESH:D007418",
      "NCIT:C34733",
      "SCTID:235825006",
      "UMLS:C0021847"
    ],
    "synonyms": [
      "Chronic intestinal pseudo-obstruction.",
      "intestinal pseudo-obstruction",
      "intestine pseudoobstruction",
      "pseudo-obstruction of intestine",
      "hollow visceral myopathy",
      "intestinal pseudoobstruction"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Intestinal pseudo-obstruction is a digestive disorder in whichthe intestinal walls are unable to contract normally (called hypomotility); the conditionresembles a true obstruction, but no actual blockage exists. Signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive ; and other symptoms. It may be classified as neuropathic (from lack of nerve function)or myopathic (from lack of muscle function), depending on the source of the abnormality. The condition is sometimes inherited (in an X-linked recessive or autosomal dominant manner)and may be caused by mutations in the FLNA gene; it may also be acquired after certain illnesses. The goal of treatment is to provide relief from symptoms andensure that nutritional support is adequate."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6365,
      "label": "ileus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6363
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8440",
          "MEDGEN:219874",
          "MESH:D045823",
          "NCIT:C37979",
          "SCTID:710572000",
          "UMLS:C1258215"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Decrease in peristalsis in the absence of a mechanical bowel obstruction."
      },
      "child_count": 3,
      "reference_id": "MONDO:0004567"
    }
  ],
  "children": [
    {
      "id": 4827,
      "label": "colonic pseudo-obstruction",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4828,
        4829
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3876",
          "GARD:0007248",
          "ICD9:564.89",
          "MEDGEN:3167",
          "MESH:D003112",
          "SCTID:35065006",
          "UMLS:C0009377"
        ],
        "synonyms": [
          "Ogilvie's syndrome",
          "ACPO",
          "acute colonic ileus",
          "acute colonic pseudo-obstruction"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Functional obstruction of the colon leading to megacolon in the absence of obvious colonic diseases or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002801"
    },
    {
      "id": 17855,
      "label": "chronic intestinal pseudoobstruction",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4829,
        20415
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012744",
          "MEDGEN:536759",
          "NANDO:1200458",
          "NANDO:2200946",
          "NORD:970",
          "Orphanet:2978",
          "SCTID:235828008",
          "UMLS:C0238062"
        ],
        "synonyms": [
          "CIPO",
          "Chronic Intestinal Pseudo-Obstruction",
          "chronic intestinal pseudo-obstruction",
          "cipo",
          "intestinal pseudo-obstruction, chronic"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Chronic intestinal pseudo-obstruction (CIPO) is a rare gastrointestinal motility disorder characterized by recurring episodes resembling mechanical obstruction in the absence of organic, systemic, or metabolic disorders, and without any physical obstruction being detected by X-ray or during surgery. CIPO develops predominantly in children and may be present at birth."
      },
      "child_count": 10,
      "reference_id": "MONDO:0017574"
    }
  ],
  "roots": [
    {
      "id": 6365,
      "label": "ileus"
    }
  ]
}