{
  "id": 4887,
  "label": "testicular pure germ cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002874",
  "properties": {
    "xrefs": [
      "DOID:4087",
      "GARD:0023284",
      "MEDGEN:308089",
      "NCIT:C39915",
      "UMLS:C1514608"
    ],
    "synonyms": [
      "testicular Pure germ cell tumor",
      "testicular Pure germ cell tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A germ cell tumor that arises from the testis and is characterized by the presence of one histologic component. This category includes seminoma, teratoma, embryonal carcinoma, yolk sac tumor, and trophoblastic tumor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 11294,
      "label": "testicular germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18335,
        20517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5557",
          "EFO:1000566",
          "GARD:0013047",
          "ICD9:239.5",
          "MEDGEN:277809",
          "MESH:C563236",
          "NCIT:C8591",
          "OMIM:273300",
          "Orphanet:363504",
          "SCTID:713577007",
          "UMLS:C1336708"
        ],
        "synonyms": [
          "TGCT",
          "germ cell neoplasm of testis",
          "germ cell neoplasm of the testis",
          "germ cell tumor of testis",
          "germ cell tumor of the testis",
          "germ cell tumors, somatic",
          "germ cell tumour of testis",
          "germ cell tumour of the testis",
          "male germ cell tumor, somatic",
          "spermatocytic seminoma, somatic",
          "testicular germ cell neoplasm",
          "testicular germ cell neoplasms",
          "testicular germ cell tumor",
          "testicular tumor, somatic",
          "testis germ cell tumor",
          "testis germ cell tumour",
          "Male germ cell tumor",
          "Male germ cell tumour",
          "embryonal cell carcinoma",
          "endodermal sinus tumor",
          "endodermal sinus tumour",
          "nonseminomatous germ cell tumors",
          "nonseminomatous germ cell tumours",
          "seminoma",
          "spermatocytic seminoma",
          "teratoma, testicular",
          "testicular germ cell cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A germ cell tumor arising from the testis. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0010108"
    }
  ],
  "children": [
    {
      "id": 4885,
      "label": "testicular trophoblastic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4886,
        4887,
        7954
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4084",
          "GARD:0023283",
          "MEDGEN:272844",
          "NCIT:C39934",
          "UMLS:C1515301"
        ],
        "synonyms": [
          "testicular trophoblastic tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A tumor that arises from the testis and is composed of neoplastic trophoblastic cells. The vast majority of cases are choriocarcinomas."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002871"
    },
    {
      "id": 5334,
      "label": "testicular yolk sac tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4887,
        5335,
        7365
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5344",
          "EFO:1000574",
          "GARD:0023502",
          "MEDGEN:79028",
          "NCIT:C8000",
          "ONCOTREE:TYST",
          "UMLS:C0279708"
        ],
        "synonyms": [
          "testicular yolk Sac neoplasm",
          "testicular yolk sac tumor",
          "testis yolk sac tumor",
          "testis yolk sac tumour",
          "Orchidoblastoma",
          "endodermal sinus neoplasm of testis",
          "endodermal sinus neoplasm of the testis",
          "endodermal sinus tumor of testis",
          "endodermal sinus tumor of the testis",
          "endodermal sinus tumour of testis",
          "endodermal sinus tumour of the testis",
          "endodermal-sinus tumor",
          "endodermal-sinus tumour",
          "testicular endodermal sinus neoplasm",
          "testicular endodermal sinus tumor",
          "testicular endodermal sinus tumour",
          "yolk Sac neoplasm of testis",
          "yolk Sac neoplasm of the testis",
          "yolk Sac tumor of testis",
          "yolk Sac tumor of the testis",
          "yolk Sac tumour of testis",
          "yolk Sac tumour of the testis",
          "yolk sac tumor",
          "yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-seminomatous malignant germ cell tumor arising from the testis. It affects infants, young children, and postpubertal males. It is the most frequently seen testicular neoplasm during childhood. The vast majority of patients present with an asymptomatic scrotal mass. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). It metastasizes to distant anatomic sites. Prognostic factors relate to the clinical stage and the degree of AFP elevation."
      },
      "child_count": 30,
      "reference_id": "MONDO:0003402"
    },
    {
      "id": 5554,
      "label": "testicular seminoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4887,
        5000,
        5424
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5842",
          "EFO:0003101",
          "GARD:0004792",
          "HP:0100617",
          "ICD9:186.9",
          "MEDGEN:1790467",
          "NCIT:C7328",
          "Orphanet:842",
          "SCTID:255107005",
          "UMLS:C5551428"
        ],
        "synonyms": [
          "seminoma of testis",
          "seminoma of the testis",
          "seminomatous germ cell tumor of testis",
          "seminomatous germ cell tumour of testis",
          "testicular seminoma",
          "testicular seminoma (disease)",
          "testicular seminoma Pure",
          "testicular seminomatous germ cell tumor",
          "testicular seminomatous germ cell tumour",
          "testis seminoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor arising from the testis. It is believed that it is derived from the sexually undifferentiated embryonic gonad. Treatment with radiotherapy is highly successful when the tumor is diagnosed in localized stages, which represents the majority of presentations of seminoma."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003669"
    },
    {
      "id": 7953,
      "label": "testicular embryonal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4887,
        5335,
        7107,
        7212
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5680",
          "EFO:1000565",
          "GARD:0024413",
          "MEDGEN:66771",
          "NCIT:C6341",
          "UMLS:C0238448"
        ],
        "synonyms": [
          "embryonal carcinoma of testis",
          "embryonal carcinoma of the testis",
          "embryonal testis carcinoma",
          "testicular embryonal carcinoma",
          "testis embryonal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell neoplasm arising from the testis. It is composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations. Most patients present with a testicular mass, which may be associated with pain. More than half of the patients have metastatic disease at diagnosis. The form of treatment following radical orchiectomy is stage dependent."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006446"
    }
  ],
  "roots": [
    {
      "id": 11294,
      "label": "testicular germ cell tumor"
    }
  ]
}