{
  "id": 4983,
  "label": "papillary squamous carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002979",
  "properties": {
    "xrefs": [
      "DOID:4385",
      "ICDO:8052/3",
      "MEDGEN:83115",
      "NCIT:C4102",
      "UMLS:C0334244"
    ],
    "synonyms": [
      "papillary epidermoid carcinoma",
      "papillary epidermoid cell carcinoma",
      "papillary squamous carcinoma",
      "papillary squamous cell carcinoma"
    ],
    "definition": "A well differentiated squamous cell carcinoma characterized by a papillary, exophytic growth pattern and hyperkeratosis. The most commonly affected anatomic sites are the larynx, penis, cervix, vagina, and vulva."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 8000,
      "label": "papillary carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        20336
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3113",
          "EFO:1000646",
          "ICDO:8050/3",
          "MEDGEN:40105",
          "MESH:D002291",
          "NCIT:C2927",
          "UMLS:C0007133"
        ],
        "synonyms": [
          "papillary carcinoma",
          "papillary carcinoma (morphologic abnormality)",
          "papillary carcinoma NOS (morphologic abnormality)"
        ],
        "definition": "A malignant epithelial neoplasm characterized by a papillary growth pattern. A papillary carcinoma may be composed of glandular cells (papillary adenocarcinoma), squamous cells (papillary squamous cell carcinoma), or transitional cells (papillary transitional cell carcinoma). Bladder carcinoma is a representative example of papillary transitional cell carcinoma."
      },
      "child_count": 10,
      "reference_id": "MONDO:0006509"
    }
  ],
  "children": [
    {
      "id": 6241,
      "label": "papillary carcinoma of the penis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4983,
        18435
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8013",
          "GARD:0024002",
          "MEDGEN:235455",
          "NCIT:C6983",
          "UMLS:C1335322"
        ],
        "synonyms": [
          "papillary carcinoma of penis",
          "papillary carcinoma of the penis",
          "papillary penile carcinoma",
          "papillary penile squamous carcinoma",
          "papillary squamous carcinoma of penis",
          "papillary squamous carcinoma of the penis",
          "penis papillary carcinoma",
          "squamous carcinoma of penis, papillary type",
          "squamous carcinoma of the penis, papillary type"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the penis and is characterized by the presence of a papillary growth pattern."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004433"
    },
    {
      "id": 7597,
      "label": "verrucous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3737",
          "EFO:0007535",
          "ICD9:199.1",
          "ICDO:8051/3",
          "MEDGEN:60213",
          "MESH:D018289",
          "NCIT:C3781",
          "SCTID:403904009",
          "UMLS:C0206706"
        ],
        "synonyms": [
          "verrucous carcinoma",
          "verrucous carcinoma NOS (morphologic abnormality)",
          "verrucous epidermoid carcinoma",
          "verrucous epidermoid cell carcinoma",
          "verrucous squamous carcinoma",
          "verrucous squamous cell carcinoma",
          "warty carcinoma"
        ],
        "definition": "A well differentiated squamous cell carcinoma characterized by a papillary growth pattern, acanthosis, mild cytologic atypia, and pushing tumor margins. The most commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, esophagus, anus, vagina, vulva, and the plantar region of the foot."
      },
      "child_count": 10,
      "reference_id": "MONDO:0006006"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 8000,
      "label": "papillary carcinoma"
    }
  ]
}