{
  "id": 4984,
  "label": "peripheral primitive neuroectodermal tumor of bone",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002981",
  "properties": {
    "xrefs": [
      "DOID:4388",
      "GARD:0023312",
      "MEDGEN:163179",
      "NCIT:C8776",
      "UMLS:C0855009"
    ],
    "synonyms": [
      "bone peripheral neuroepithelioma",
      "bone tissue peripheral primitive neuroectodermal tumor",
      "bone tissue peripheral primitive neuroectodermal tumour",
      "osseous peripheral neuroepithelioma",
      "peripheral neuroectodermal tumor of bone",
      "peripheral neuroectodermal tumor of the bone",
      "peripheral neuroectodermal tumour of bone",
      "peripheral neuroectodermal tumour of the bone",
      "peripheral neuroepithelioma of bone",
      "peripheral neuroepithelioma of the bone",
      "peripheral primitive neuroectodermal tumor of bone",
      "peripheral primitive neuroectodermal tumor of bone tissue",
      "peripheral primitive neuroectodermal tumour of bone tissue"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A small round cell tumor with neural differentiation arising from the bone. It may be associated with pain."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4262,
      "label": "bone cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3041,
        18958
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2019-1041",
          "DOID:184",
          "EFO:1000350",
          "GARD:0023070",
          "ICD9:170.9",
          "MEDGEN:79002",
          "MESH:D001859",
          "NCIT:C4016",
          "SCTID:428281000",
          "UMLS:C0279530"
        ],
        "synonyms": [
          "bone neoplasm",
          "bone tumor",
          "bone tumour",
          "osseous tumor",
          "osseous tumour",
          "bone cancer",
          "cancer of bone",
          "cancer of skeletal element",
          "cancer of the bone",
          "malignant bone neoplasm",
          "malignant bone tumor",
          "malignant neoplasm of bone",
          "malignant neoplasm of skeletal element",
          "malignant neoplasm of the bone",
          "malignant osseous neoplasm",
          "malignant osseous tumor",
          "malignant osseous tumour",
          "malignant skeletal element neoplasm",
          "malignant tumor of bone",
          "malignant tumor of the bone",
          "malignant tumour of bone",
          "malignant tumour of the bone",
          "osseous cancer",
          "skeletal element cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the bone or articular cartilage."
      },
      "child_count": 24,
      "reference_id": "MONDO:0002129"
    },
    {
      "id": 18390,
      "label": "peripheral primitive neuroectodermal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7121,
        20283,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017601",
          "ICDO:9364/3",
          "MEDGEN:151926",
          "NANDO:2200054",
          "NANDO:2200055",
          "NCIT:C9341",
          "Orphanet:370348",
          "UMLS:C0684337"
        ],
        "synonyms": [
          "PPNET",
          "pPNET",
          "peripheral PNET",
          "peripheral neuroectodermal neoplasm",
          "peripheral neuroectodermal tumor",
          "peripheral neuroectodermal tumour",
          "peripheral neuroepithelioma",
          "peripheral primitive neuroectodermal neoplasm",
          "peripheral primitive neuroectodermal tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A small round cell tumor with neural differentiation arising from the soft tissues or bone."
      },
      "child_count": 9,
      "reference_id": "MONDO:0018271"
    },
    {
      "id": 20361,
      "label": "Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18958,
        20283
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025291",
          "MEDGEN:272598",
          "NCIT:C35871",
          "UMLS:C1333481"
        ],
        "synonyms": [
          "Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone",
          "Ewing's sarcoma/peripheral primitive neuroectodermal tumor of bone",
          "Ewing's sarcoma/peripheral primitive neuroectodermal tumour of bone",
          "bone tissue Ewing sarcoma/peripheral primitive neuroectodermal tumor",
          "bone tissue Ewing sarcoma/peripheral primitive neuroectodermal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A spectrum of malignant tumors arising from the bone and characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. Pain and the presence of a mass are the most common clinical symptoms."
      },
      "child_count": 4,
      "reference_id": "MONDO:0021123"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4262,
      "label": "bone cancer"
    },
    {
      "id": 18390,
      "label": "peripheral primitive neuroectodermal tumor"
    },
    {
      "id": 20361,
      "label": "Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone"
    }
  ]
}