{
  "id": 4993,
  "label": "pancreatic delta cell neuroendocrine tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002994",
  "properties": {
    "xrefs": [
      "DOID:4433",
      "GARD:0023315",
      "MEDGEN:233303",
      "NCIT:C28396",
      "UMLS:C1335301"
    ],
    "synonyms": [
      "pancreatic Delta cell NET",
      "pancreatic Delta cell neoplasm",
      "pancreatic Delta cell neuroendocrine tumor",
      "pancreatic Delta cell neuroendocrine tumour",
      "pancreatic Delta cell tumor",
      "pancreatic Delta cell tumour",
      "pancreatic delta cell neoplasm"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A usually malignant neuroendocrine tumor arising from the delta cells of the pancreas. It may be associated with inappropriate secretion of somatostatin and an associated clinical syndrome, or it may be hormonally inactive (non-functioning)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7265,
      "label": "epithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006858",
          "MEDGEN:277963",
          "MESH:D009375",
          "NCIT:C3709",
          "SCTID:118285006",
          "UMLS:C1368683"
        ],
        "synonyms": [
          "epithelial neoplasm",
          "epithelioma"
        ],
        "definition": "A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas."
      },
      "child_count": 24,
      "reference_id": "MONDO:0005626"
    },
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        7431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000045",
          "GARD:0013034",
          "ICDO:8150/1",
          "MEDGEN:277875",
          "NCIT:C27720",
          "ONCOTREE:PANET",
          "Orphanet:97253",
          "UMLS:C1337011"
        ],
        "synonyms": [
          "islet cell tumor",
          "islet cell tumors - pancreas",
          "islet cell tumors of the pancreas",
          "islet cell tumour",
          "islet cell tumours - pancreas",
          "islet cell tumours of the pancreas",
          "pancreatic NET",
          "pancreatic neuroendocrine tumor",
          "well differentiated pancreatic endocrine neoplasm",
          "well differentiated pancreatic endocrine tumor",
          "well differentiated pancreatic endocrine tumour",
          "well-differentiated NEN of pancreas",
          "well-differentiated neuroendocrine neoplasm of pancreas",
          "well-differentiated pancreatic NEN",
          "well-differentiated pancreatic neuroendocrine neoplasm",
          "PANET",
          "neuroendocrine tumor of pancreas",
          "neuroendocrine tumour of pancreas",
          "pancreatic endocrine tumor",
          "pancreatic endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. They can be functional, exhibiting a hormonal hypersecretion syndrome, but can be non-functional presenting with non-specific symptoms and include insulinoma, glucagonoma, VIPoma, somatostatinoma (SSoma), PPoma and Zollinger-Ellison syndrome (ZES, or gastrinoma) and other ectopic hormone producing tumors (such as GRFoma)."
      },
      "child_count": 22,
      "reference_id": "MONDO:0019954"
    }
  ],
  "children": [
    {
      "id": 4992,
      "label": "pancreatic somatostatinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4993
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4432",
          "GARD:0023314",
          "MEDGEN:235079",
          "NCIT:C95595",
          "UMLS:C1368041"
        ],
        "synonyms": [
          "pancreatic somatostatin cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine tumor arising from the delta cells of the pancreas. It is characterized by inappropriate secretion of somatostatin and associated with diabetes mellitus, hypochlorhydria, gallbladder disease, diarrhea, steatorrhea, anemia, and weight loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002993"
    },
    {
      "id": 6190,
      "label": "pancreatic non-functioning delta cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4993,
        6150
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7840",
          "GARD:0023968",
          "MEDGEN:235453",
          "NCIT:C28333",
          "UMLS:C1335311"
        ],
        "synonyms": [
          "non-functional pancreatic Delta cell NET",
          "non-functional pancreatic Delta cell neuroendocrine tumor",
          "non-functional pancreatic Delta cell neuroendocrine tumour",
          "non-functioning pancreatic Delta cell neoplasm",
          "non-functioning pancreatic Delta cell tumor",
          "non-functioning pancreatic Delta cell tumour",
          "nonfunctional Pancreatic Delta cell Neuroendocrine tumor",
          "nonfunctional Pancreatic Delta cell Neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually malignant neuroendocrine tumor arising from the delta cells of the pancreas. It is not associated with a hormonal syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004377"
    }
  ],
  "roots": [
    {
      "id": 7265,
      "label": "epithelial neoplasm"
    },
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor"
    }
  ]
}