{
  "id": 4994,
  "label": "small intestine neuroendocrine tumor, well differentiated, low or intermediate grade",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002995",
  "properties": {
    "xrefs": [
      "GARD:0023316",
      "MEDGEN:474161",
      "NCIT:C96061",
      "UMLS:C3272528"
    ],
    "synonyms": [
      "small intestinal NET",
      "small intestinal neuroendocrine tumor",
      "small intestinal neuroendocrine tumour",
      "small intestinal well differentiated endocrine tumor",
      "small intestinal well differentiated endocrine tumour",
      "small intestine neuroendocrine tumor",
      "small intestine neuroendocrine tumour",
      "small intestinal well differentiated endocrine tumor/carcinoma",
      "carcinoid tumor of small intestine",
      "carcinoid tumour of small intestine"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the small intestine."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050626",
          "GARD:0022761",
          "MEDGEN:443945",
          "NCIT:C95404",
          "ONCOTREE:GINET",
          "UMLS:C2930967"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system neuroendocrine tumor",
          "alimentary part of gastrointestinal system neuroendocrine tumour",
          "digestive system NET",
          "digestive system neuroendocrine tumor",
          "digestive system neuroendocrine tumour",
          "digestive system well differentiated neuroendocrine tumor",
          "digestive system well differentiated neuroendocrine tumour",
          "gastroenteropancreatic NET",
          "gastroenteropancreatic neuroendocrine tumor",
          "gastroenteropancreatic neuroendocrine tumour",
          "gastrointestinal NET",
          "gastrointestinal neuroendocrine tumor",
          "gastrointestinal neuroendocrine tumors",
          "gastrointestinal neuroendocrine tumour",
          "gastrointestinal neuroendocrine tumours",
          "gastrointestinal system neuroendocrine tumor",
          "gastrointestinal system neuroendocrine tumour",
          "malignant gastrointestinal neuroendocrine tumor",
          "malignant gastrointestinal neuroendocrine tumour",
          "GINET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000386"
    },
    {
      "id": 18542,
      "label": "small intestine neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4896,
        6071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4434",
          "EFO:1001928",
          "GARD:0021765",
          "MEDGEN:233453",
          "NCIT:C5803",
          "Orphanet:423975",
          "UMLS:C1336005"
        ],
        "synonyms": [
          "NET of the small intestine",
          "neuroendocrine neoplasm of small intestine",
          "neuroendocrine neoplasm of the small intestine",
          "neuroendocrine tumor of small bowel",
          "neuroendocrine tumour of small bowel",
          "small intestinal neuroendocrine neoplasm",
          "small intestine NET",
          "small intestine neuroendocrine neoplasm",
          "small intestine neuroendocrine tumor",
          "small intestine neuroendocrine tumour",
          "neuroendocrine tumor of the small intestine",
          "neuroendocrine tumour of the small intestine",
          "small intestine neuroendocrine tumor, well differentiated, low or intermediate grade"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the small intestine. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018510"
    }
  ],
  "children": [
    {
      "id": 2982,
      "label": "small intestinal neuroendocrine tumor G1",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4994,
        20650
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050925",
          "GARD:0022796",
          "MEDGEN:91150",
          "NCIT:C4638",
          "SCTID:276818002",
          "UMLS:C0349536"
        ],
        "synonyms": [
          "carcinoid tumor of small bowel",
          "carcinoid tumor of small intestine",
          "carcinoid tumor of the small bowel",
          "carcinoid tumor of the small intestine",
          "carcinoid tumour of small bowel",
          "carcinoid tumour of small intestine",
          "carcinoid tumour of the small bowel",
          "carcinoid tumour of the small intestine",
          "grade 1 neuroendocrine neoplasm of small intestine",
          "small bowel carcinoid tumor",
          "small bowel carcinoid tumour",
          "small intestinal NET G1",
          "small intestinal carcinoid tumor",
          "small intestinal carcinoid tumour",
          "small intestinal neuroendocrine tumor G1",
          "small intestine NET G1",
          "small intestine carcinoid tumor",
          "small intestine carcinoid tumor (disease)",
          "small intestine carcinoid tumour",
          "small intestine carcinoid tumour (disease)",
          "small intestine neuroendocrine neoplasm G1",
          "small intestine neuroendocrine tumor, well differentiated, low grade",
          "small intestine carcinoid neuroendocrine tumor",
          "small intestine carcinoid neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the small intestine. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent."
      },
      "child_count": 4,
      "reference_id": "MONDO:0000540"
    },
    {
      "id": 5513,
      "label": "small intestinal vasoactive intestinal peptide producing tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4994,
        19676
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5740",
          "GARD:0023590",
          "MEDGEN:277655",
          "NCIT:C27455",
          "UMLS:C1336009"
        ],
        "synonyms": [
          "small intestinal VIP-producing NET",
          "small intestinal VIP-producing neuroendocrine tumor",
          "small intestinal VIP-producing neuroendocrine tumour",
          "small intestinal VIPoma",
          "small intestinal vasoactive intestinal peptide producing tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine tumor that arises from the small intestine and produces vasoactive intestinal peptide."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003621"
    },
    {
      "id": 6072,
      "label": "small intestinal L-cell glucagon-like peptide producing tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4994,
        6033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7506",
          "GARD:0023900",
          "MEDGEN:475776",
          "NCIT:C27452",
          "UMLS:C3274143"
        ],
        "synonyms": [
          "L-cell glucagon-like peptide-producing neuroendocrine tumor of small intestine",
          "L-cell glucagon-like peptide-producing neuroendocrine tumour of small intestine",
          "small intestinal L-cell glucagon-like peptide-producing NET",
          "small intestinal L-cell glucagon-like peptide-producing neuroendocrine tumor",
          "small intestinal L-cell glucagon-like peptide-producing neuroendocrine tumour",
          "small intestinal L-cell, glucagon-like peptide-producing neuroendocrine tumor",
          "small intestinal L-cell, glucagon-like peptide-producing neuroendocrine tumour",
          "small intestine L-cell glucagon-like peptide-producing neuroendocrine tumor",
          "small intestine L-cell glucagon-like peptide-producing neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine tumor that arises from the small intestine and produces glucagon-like peptides. Morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004252"
    },
    {
      "id": 16037,
      "label": "duodenal neuroendocrine tumor, well differentiated, low or intermediate grade",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4994,
        21453
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019751",
          "MEDGEN:1619951",
          "NCIT:C135080",
          "Orphanet:100076",
          "UMLS:C4525619"
        ],
        "synonyms": [
          "duodenal neuroendocrine tumor",
          "duodenal neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the duodenum."
      },
      "child_count": 4,
      "reference_id": "MONDO:0015063"
    },
    {
      "id": 16038,
      "label": "jejunal neuroendocrine tumor, well differentiated, low or intermediate grade",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4628,
        4994
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019752",
          "MEDGEN:1619460",
          "NCIT:C135090",
          "Orphanet:100077",
          "UMLS:C4525626"
        ],
        "synonyms": [
          "jejunal neuroendocrine neoplasm",
          "jejunal neuroendocrine tumor",
          "jejunal neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the jejunum."
      },
      "child_count": 4,
      "reference_id": "MONDO:0015064"
    },
    {
      "id": 16039,
      "label": "ileal neuroendocrine tumor, well differentiated, low or intermediate grade",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4994,
        8249
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019753",
          "MEDGEN:1611292",
          "NCIT:C135092",
          "Orphanet:100078",
          "UMLS:C4525628"
        ],
        "synonyms": [
          "ileal neuroendocrine neoplasm",
          "ileal neuroendocrine tumor",
          "ileal neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the ileum."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015065"
    }
  ],
  "roots": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2"
    },
    {
      "id": 18542,
      "label": "small intestine neuroendocrine neoplasm"
    }
  ]
}