{
  "id": 4998,
  "label": "central nervous system germinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002999",
  "properties": {
    "xrefs": [
      "DOID:4438",
      "GARD:0023320",
      "MEDGEN:232242",
      "NCIT:C7009",
      "UMLS:C1333813"
    ],
    "synonyms": [
      "central nervous system germinoma",
      "central nervous system germinoma (disease)",
      "germinoma of CNS",
      "germinoma of central nervous system",
      "germinoma of the CNS",
      "germinoma of the central nervous system",
      "intracranial germinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A malignant germ cell tumor arising from the central nervous system. It is composed of uniform cells resembling primitive germ cells. These cells have large, vesicular nuclei, prominent nucleoli and a clear, glycogen-rich cytoplasm. Additional features are lymphoid or lymphoplasmacytic infiltrates and, less frequently, scattered syncytiotrophoblastic giant cells. (Adapted from WHO)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4753,
      "label": "central nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7479,
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3620",
          "EFO:0000326",
          "GARD:0027614",
          "ICD9:239.7",
          "MEDGEN:87593",
          "MESH:D016543",
          "NANDO:2100007",
          "NCIT:C4627",
          "SCTID:126951006",
          "UMLS:C0348374"
        ],
        "synonyms": [
          "CNS neoplasm",
          "central nervous system tumor",
          "central nervous system tumour",
          "CNS cancer",
          "CNS malignant neoplasms",
          "CNS neoplasms, malignant",
          "cancer of CNS",
          "cancer of central nervous system",
          "cancer of the CNS",
          "cancer of the central nervous system",
          "central nervous system cancer",
          "central nervous system neoplasms, malignant",
          "central nervous system tumours",
          "malignant CNS neoplasm",
          "malignant CNS neoplasms",
          "malignant CNS tumor",
          "malignant CNS tumour",
          "malignant central nervous system neoplasm",
          "malignant central nervous system tumor",
          "malignant central nervous system tumour",
          "malignant neoplasm of CNS",
          "malignant neoplasm of central nervous system",
          "malignant neoplasm of the CNS",
          "malignant neoplasm of the central nervous system",
          "malignant tumor of CNS",
          "malignant tumor of central nervous system",
          "malignant tumor of the CNS",
          "malignant tumor of the central nervous system",
          "malignant tumour of CNS",
          "malignant tumour of central nervous system",
          "malignant tumour of the CNS",
          "malignant tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the central nervous system"
      },
      "child_count": 40,
      "reference_id": "MONDO:0002714"
    },
    {
      "id": 4999,
      "label": "central nervous system germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7694,
        18334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4439",
          "GARD:0023321",
          "MEDGEN:232040",
          "NCIT:C5461",
          "UMLS:C1332880"
        ],
        "synonyms": [
          "CNS germ cell neoplasm",
          "CNS germ cell tumor",
          "CNS germ cell tumour",
          "central nervous system germ cell neoplasm",
          "central nervous system germ cell tumor",
          "central nervous system rare germ cell tumor",
          "central nervous system rare germ cell tumour",
          "germ cell neoplasm of CNS",
          "germ cell neoplasm of central nervous system",
          "germ cell neoplasm of the CNS",
          "germ cell neoplasm of the central nervous system",
          "germ cell tumor of CNS",
          "germ cell tumor of central nervous system",
          "germ cell tumor of the CNS",
          "germ cell tumor of the central nervous system",
          "germ cell tumour of CNS",
          "germ cell tumour of central nervous system",
          "germ cell tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A unique group of rare tumors of the central nervous system that affect mainly children and adolescents. Their morphologic and biologic profile corresponds to that of homologous germ cell tumors that arise in the gonads and in other extragonadal sites. Representative examples include: germinoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003000"
    },
    {
      "id": 16619,
      "label": "extragonadal germinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4654,
        5094
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002005",
          "MEDGEN:1673080",
          "MedDRA:10018207",
          "Orphanet:182127",
          "UMLS:C5190513"
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0015935"
    }
  ],
  "children": [
    {
      "id": 4334,
      "label": "brain germinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3853,
        4998
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2127",
          "GARD:0023086",
          "MEDGEN:231457",
          "NCIT:C6284",
          "UMLS:C1332606"
        ],
        "synonyms": [
          "intracranial germinoma",
          "brain germinoma (disease)",
          "germinoma of brain",
          "germinoma of the brain"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A germinoma (disease) that involves the brain."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002214"
    },
    {
      "id": 6196,
      "label": "adult central nervous system germinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4998,
        5337
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7867",
          "GARD:0023970",
          "MEDGEN:234581",
          "NCIT:C5792",
          "UMLS:C1370504"
        ],
        "synonyms": [
          "central nervous system germinoma",
          "adult CNS germinoma",
          "adult central nervous system germinoma",
          "central nervous system germinoma of adults",
          "germinoma of adult CNS",
          "germinoma of adult central nervous system",
          "germinoma of the adult CNS",
          "germinoma of the adult central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A central nervous system germinoma that occurs in an adult."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004383"
    },
    {
      "id": 6258,
      "label": "childhood central nervous system germinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4998,
        5630,
        6283
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8078",
          "GARD:0024013",
          "MEDGEN:272460",
          "NCIT:C27406",
          "UMLS:C1332953"
        ],
        "synonyms": [
          "Central nervous system germinoma",
          "central nervous system germinoma of childhood",
          "paediatric central nervous system germinoma",
          "pediatric central nervous system germinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A germinoma arising from the central nervous system during childhood."
      },
      "child_count": 3,
      "reference_id": "MONDO:0004452"
    }
  ],
  "roots": [
    {
      "id": 4753,
      "label": "central nervous system cancer"
    },
    {
      "id": 4999,
      "label": "central nervous system germ cell tumor"
    },
    {
      "id": 16619,
      "label": "extragonadal germinoma"
    }
  ]
}