{
  "id": 4999,
  "label": "central nervous system germ cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003000",
  "properties": {
    "xrefs": [
      "DOID:4439",
      "GARD:0023321",
      "MEDGEN:232040",
      "NCIT:C5461",
      "UMLS:C1332880"
    ],
    "synonyms": [
      "CNS germ cell neoplasm",
      "CNS germ cell tumor",
      "CNS germ cell tumour",
      "central nervous system germ cell neoplasm",
      "central nervous system germ cell tumor",
      "central nervous system rare germ cell tumor",
      "central nervous system rare germ cell tumour",
      "germ cell neoplasm of CNS",
      "germ cell neoplasm of central nervous system",
      "germ cell neoplasm of the CNS",
      "germ cell neoplasm of the central nervous system",
      "germ cell tumor of CNS",
      "germ cell tumor of central nervous system",
      "germ cell tumor of the CNS",
      "germ cell tumor of the central nervous system",
      "germ cell tumour of CNS",
      "germ cell tumour of central nervous system",
      "germ cell tumour of the central nervous system"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A unique group of rare tumors of the central nervous system that affect mainly children and adolescents. Their morphologic and biologic profile corresponds to that of homologous germ cell tumors that arise in the gonads and in other extragonadal sites. Representative examples include: germinoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 7694,
      "label": "central nervous system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000158",
          "MEDGEN:88335",
          "NCIT:C9293",
          "UMLS:C0085136"
        ],
        "synonyms": [
          "CNS neoplasm",
          "CNS tumor",
          "CNS tumour",
          "brain/spinal cord tumor",
          "brain/spinal cord tumour",
          "central nervous system neoplasm",
          "central nervous system neoplasm (disease)",
          "central nervous system tumor",
          "central nervous system tumour",
          "neoplasm of CNS",
          "neoplasm of central nervous system",
          "neoplasm of the central nervous system",
          "tumor of CNS",
          "tumor of central nervous system",
          "tumor of the CNS",
          "tumor of the central nervous system",
          "tumour of CNS",
          "tumour of central nervous system",
          "tumour of the CNS",
          "tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia."
      },
      "child_count": 20,
      "reference_id": "MONDO:0006130"
    },
    {
      "id": 18334,
      "label": "extragonadal germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009325",
          "MEDGEN:75506",
          "NCIT:C3918",
          "Orphanet:363579",
          "UMLS:C0262963"
        ],
        "synonyms": [
          "extragonadal germ cell neoplasm",
          "extragonadal germ cell neoplasms",
          "extragonadal germ cell tumor",
          "neoplasm of extragonadal germ cell",
          "neoplasm of the extragonadal germ cell",
          "primary extragonadal germ cell tumor",
          "primary extragonadal germ cell tumour",
          "tumor of extragonadal germ cell",
          "tumor of the extragonadal germ cell",
          "tumour of extragonadal germ cell",
          "tumour of the extragonadal germ cell"
        ],
        "definition": "A germ cell tumor arising in an anatomic site other than the testis or ovary (e.g., central nervous system, lung, mediastinum, and retroperitoneum)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018201"
    }
  ],
  "children": [
    {
      "id": 4216,
      "label": "malignant pineal area germ cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4999,
        5094,
        5194
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1660",
          "GARD:0012017",
          "ICD9:239.7",
          "MEDGEN:233159",
          "NCIT:C6767",
          "SCTID:277508009",
          "UMLS:C1334612"
        ],
        "synonyms": [
          "malignant germ cell neoplasm of pineal gland",
          "malignant germ cell neoplasm of pineal parenchyma",
          "malignant germ cell neoplasm of the pineal gland",
          "malignant germ cell neoplasm of the pineal parenchyma",
          "malignant germ cell tumor of pineal gland",
          "malignant germ cell tumor of pineal parenchyma",
          "malignant germ cell tumor of the pineal gland",
          "malignant germ cell tumor of the pineal parenchyma",
          "malignant germ cell tumour of pineal gland",
          "malignant germ cell tumour of pineal parenchyma",
          "malignant germ cell tumour of the pineal gland",
          "malignant germ cell tumour of the pineal parenchyma",
          "malignant pineal area germ cell tumor",
          "malignant pineal area germ cell tumour",
          "malignant pineal gland germ cell neoplasm",
          "malignant pineal gland germ cell tumor",
          "malignant pineal gland germ cell tumour",
          "malignant pineal parenchymal germ cell neoplasm",
          "malignant pineal parenchymal germ cell tumor",
          "malignant pineal parenchymal germ cell tumour",
          "malignant pineal region germ cell neoplasm",
          "malignant pineal region germ cell tumor",
          "malignant pineal region germ cell tumour",
          "pineal germ cell neoplasm, malignant",
          "pineal germ cell tumour",
          "pineal region germ cell tumour",
          "pineal cell tumor",
          "pineal cell tumour",
          "pineal region germinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor that arises in the pineal region. Representative examples include germinoma, immature teratoma, choriocarcinoma, embryonal carcinoma and yolk sac tumor."
      },
      "child_count": 15,
      "reference_id": "MONDO:0002073"
    },
    {
      "id": 4998,
      "label": "central nervous system germinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        4999,
        16619
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4438",
          "GARD:0023320",
          "MEDGEN:232242",
          "NCIT:C7009",
          "UMLS:C1333813"
        ],
        "synonyms": [
          "central nervous system germinoma",
          "central nervous system germinoma (disease)",
          "germinoma of CNS",
          "germinoma of central nervous system",
          "germinoma of the CNS",
          "germinoma of the central nervous system",
          "intracranial germinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor arising from the central nervous system. It is composed of uniform cells resembling primitive germ cells. These cells have large, vesicular nuclei, prominent nucleoli and a clear, glycogen-rich cytoplasm. Additional features are lymphoid or lymphoplasmacytic infiltrates and, less frequently, scattered syncytiotrophoblastic giant cells. (Adapted from WHO)"
      },
      "child_count": 9,
      "reference_id": "MONDO:0002999"
    },
    {
      "id": 5337,
      "label": "adult central nervous system germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4999,
        23464
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5349",
          "GARD:0023505",
          "MEDGEN:128893",
          "NCIT:C6285",
          "UMLS:C0280796"
        ],
        "synonyms": [
          "central nervous system germ cell tumor",
          "central nervous system germ cell tumour",
          "adult CNS germ cell neoplasm",
          "adult CNS germ cell tumor",
          "adult CNS germ cell tumour",
          "adult central nervous system germ cell neoplasm",
          "adult central nervous system germ cell tumor",
          "central nervous system germ cell tumor of adults",
          "central nervous system germ cell tumour of adults",
          "germ cell neoplasm of adult CNS",
          "germ cell neoplasm of adult central nervous system",
          "germ cell neoplasm of the adult CNS",
          "germ cell neoplasm of the adult central nervous system",
          "germ cell tumor of adult CNS",
          "germ cell tumor of adult central nervous system",
          "germ cell tumor of the adult CNS",
          "germ cell tumor of the adult central nervous system",
          "germ cell tumour of adult CNS",
          "germ cell tumour of adult central nervous system",
          "germ cell tumour of the adult central nervous system",
          "central nervous system adult germ cell tumor",
          "central nervous system adult germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A germ cell tumor of the central nervous system occurring in adults."
      },
      "child_count": 10,
      "reference_id": "MONDO:0003405"
    },
    {
      "id": 5630,
      "label": "childhood central nervous system germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4999,
        5631
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6052",
          "GARD:0023650",
          "MEDGEN:124505",
          "NCIT:C6205",
          "UMLS:C0278754"
        ],
        "synonyms": [
          "central nervous system germ cell tumor",
          "central nervous system germ cell tumour",
          "central nervous system childhood germ cell tumor",
          "central nervous system paediatric germ cell cancer",
          "central nervous system pediatric germ cell cancer",
          "childhood CNS germ cell neoplasm",
          "childhood CNS germ cell tumor",
          "childhood CNS germ cell tumour",
          "childhood central nervous system germ cell neoplasm",
          "childhood central nervous system germ cell tumor",
          "childhood germ cell neoplasm of CNS",
          "childhood germ cell neoplasm of central nervous system",
          "childhood germ cell neoplasm of the CNS",
          "childhood germ cell neoplasm of the central nervous system",
          "childhood germ cell tumor of CNS",
          "childhood germ cell tumor of central nervous system",
          "childhood germ cell tumor of the CNS",
          "childhood germ cell tumor of the central nervous system",
          "childhood germ cell tumour of CNS",
          "childhood germ cell tumour of central nervous system",
          "childhood germ cell tumour of the CNS",
          "childhood germ cell tumour of the central nervous system",
          "paediatric CNS germ cell neoplasm",
          "paediatric CNS germ cell tumour",
          "paediatric central nervous system germ cell neoplasm",
          "paediatric central nervous system germ cell tumour",
          "paediatric germ cell neoplasm of central nervous system",
          "paediatric germ cell neoplasm of the CNS",
          "paediatric germ cell neoplasm of the central nervous system",
          "paediatric germ cell tumour of CNS",
          "paediatric germ cell tumour of central nervous system",
          "paediatric germ cell tumour of the CNS",
          "paediatric germ cell tumour of the central nervous system",
          "pediatric CNS germ cell neoplasm",
          "pediatric CNS germ cell tumor",
          "pediatric central nervous system germ cell neoplasm",
          "pediatric central nervous system germ cell tumor",
          "pediatric germ cell neoplasm of CNS",
          "pediatric germ cell neoplasm of central nervous system",
          "pediatric germ cell neoplasm of the CNS",
          "pediatric germ cell neoplasm of the central nervous system",
          "pediatric germ cell tumor of CNS",
          "pediatric germ cell tumor of central nervous system",
          "pediatric germ cell tumor of the CNS",
          "pediatric germ cell tumor of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A germ cell tumor of the central nervous system occurring in children."
      },
      "child_count": 16,
      "reference_id": "MONDO:0003750"
    },
    {
      "id": 17191,
      "label": "mixed germ cell tumor of central nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2973,
        4753,
        4999
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020736",
          "MEDGEN:233713",
          "NCIT:C7016",
          "Orphanet:252021",
          "UMLS:C1334785"
        ],
        "synonyms": [
          "CNS mixed germ cell tumor",
          "CNS mixed germ cell tumour",
          "central nervous system mixed germ cell tumor",
          "central nervous system mixed germ cell tumour",
          "mixed germ cell neoplasm of the central nervous system",
          "mixed germ cell tumor of CNS",
          "mixed germ cell tumor of the CNS",
          "mixed germ cell tumor of the central nervous system",
          "mixed germ cell tumour of CNS",
          "mixed germ cell tumour of the CNS",
          "mixed germ cell tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor of the central nervous system characterized by the presence of at least two types of germ cell neoplasia."
      },
      "child_count": 6,
      "reference_id": "MONDO:0016742"
    },
    {
      "id": 20012,
      "label": "central nervous system nongerminomatous germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4999,
        19983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025171",
          "MEDGEN:760465",
          "NCIT:C100093",
          "UMLS:C1696109"
        ],
        "synonyms": [
          "central nervous system nongerminomatous germ cell tumor",
          "nongerminomatous GCT - CNS",
          "nongerminomatous germ cell tumor of the CNS",
          "nongerminomatous germ cell tumour of the CNS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Germ cell tumors of the central nervous system other than germinoma. This category includes teratoma, choriocarcinoma, embryonal carcinoma, and yolk sac tumor."
      },
      "child_count": 8,
      "reference_id": "MONDO:0020574"
    }
  ],
  "roots": [
    {
      "id": 7694,
      "label": "central nervous system neoplasm"
    },
    {
      "id": 18334,
      "label": "extragonadal germ cell tumor"
    }
  ]
}