{
  "id": 5001,
  "label": "dysgerminoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003002",
  "properties": {
    "xrefs": [
      "DOID:4441",
      "GARD:0023323",
      "HP:0100621",
      "ICDO:9060/3",
      "MEDGEN:41680",
      "MESH:D004407",
      "NANDO:2200066",
      "NCIT:C2996",
      "UMLS:C0013377",
      "icd11.foundation:817547820"
    ],
    "synonyms": [
      "dysgerminoma",
      "dysgerminoma (disease)",
      "dysgerminoma, malignant"
    ],
    "definition": "A malignant germ cell tumor characterized by the presence of a monotonous primitive germ cell population. The neoplastic cells form aggregates and have an abundant pale cytoplasm and uniform nuclei. The aggregates of the germ cells are separated by fibrous septa which contain inflammatory cells, mostly T-lymphocytes. It arises primarily in the ovaries, but can occur both primarily and secondarily at other sites, particularly the central nervous system. It responds to chemotherapy and radiotherapy. Its prognosis is related to the tumor stage."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7832,
      "label": "malignant germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000352",
          "GARD:0003360",
          "MEDGEN:890580",
          "NCIT:C4925",
          "SCTID:145831000119103",
          "UMLS:C4048549"
        ],
        "synonyms": [
          "cancer of germ cell",
          "germ cell cancer",
          "germ cell tumor, malignant",
          "malignant germ cell neoplasm",
          "malignant germ cell tumor",
          "malignant neoplasm of germ cell",
          "malignant neoplasm of the germ cell",
          "malignant tumor of germ cell",
          "malignant tumor of the germ cell",
          "malignant tumour of germ cell",
          "malignant tumour of the germ cell"
        ],
        "definition": "A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0006290"
    },
    {
      "id": 20017,
      "label": "germinomatous germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025174",
          "MEDGEN:888719",
          "NCIT:C121618",
          "UMLS:C4054897"
        ],
        "synonyms": [
          "germinomatous germ cell tumor"
        ],
        "definition": "A term that refers to germinoma, seminoma, or dysgerminoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020580"
    }
  ],
  "children": [
    {
      "id": 5402,
      "label": "pineal region dysgerminoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4216,
        5001
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5510",
          "GARD:0023524",
          "MEDGEN:233328",
          "NCIT:C7169",
          "UMLS:C1335415"
        ],
        "synonyms": [
          "pineal body dysgerminoma (disease)",
          "pineal dysgerminoma",
          "pineal region dysgerminoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A dysgerminoma (disease) that involves the pineal body."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003480"
    },
    {
      "id": 5403,
      "label": "dysgerminoma of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5001,
        5339
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5511",
          "EFO:1000414",
          "GARD:0023525",
          "MEDGEN:83414",
          "NCIT:C8106",
          "ONCOTREE:ODYS",
          "SCTID:254874008",
          "UMLS:C0346185",
          "icd11.foundation:208782658"
        ],
        "synonyms": [
          "dysgerminoma of ovary",
          "dysgerminoma of the ovary",
          "germ cell dysgerminoma of ovary",
          "germ cell dysgerminoma of the ovary",
          "ovarian dysgerminoma",
          "ovarian germ cell dysgerminoma",
          "ovary dysgerminoma (disease)",
          "dysgerminoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor arising from the ovary. Morphologically, it is identical to seminoma and consists of a monotonous population of germ cells with abundant pale cytoplasm and uniform nuclei. The stroma invariably contains chronic inflammatory cells, mostly T-lymphocytes. It responds to chemotherapy or radiotherapy and the prognosis relates to the tumor stage."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003481"
    }
  ],
  "roots": [
    {
      "id": 7832,
      "label": "malignant germ cell tumor"
    },
    {
      "id": 20017,
      "label": "germinomatous germ cell tumor"
    }
  ]
}