{
  "id": 5039,
  "label": "ovarian large-cell neuroendocrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003049",
  "properties": {
    "xrefs": [
      "DOID:4555",
      "GARD:0023345",
      "MEDGEN:233809",
      "NCIT:C5238",
      "UMLS:C1335174"
    ],
    "synonyms": [
      "large cell neuroendocrine carcinoma of ovary",
      "large cell neuroendocrine carcinoma of the ovary",
      "large-cell neuroendocrine carcinoma of ovary",
      "large-cell neuroendocrine carcinoma of the ovary",
      "non-small-cell type neuroendocrine carcinoma of ovary",
      "non-small-cell type neuroendocrine carcinoma of the ovary",
      "ovarian large cell NEC",
      "ovarian large cell neuroendocrine carcinoma",
      "ovarian non-small-cell type neuroendocrine carcinoma",
      "ovary large cell neuroendocrine carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from the ovary and is characterized by the presence of large malignant cells exhibiting neuroendocrine differentiation. The prognosis is poor."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4561,
      "label": "ovarian neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9481,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3002",
          "GARD:0023145",
          "MEDGEN:277459",
          "NCIT:C5237",
          "UMLS:C1335172"
        ],
        "synonyms": [
          "neuroendocrine neoplasm of ovary",
          "neuroendocrine neoplasm of the ovary",
          "neuroendocrine tumour of ovary",
          "ovarian neuroendocrine neoplasm",
          "ovary NET",
          "ovary neuroendocrine neoplasm",
          "ovary neuroendocrine tumor",
          "ovary neuroendocrine tumor, well differentiated, low or intermediate grade",
          "ovary neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An epithelial neoplasm with neuroendocrine differentiation that arises from the ovary. It includes carcinoid tumor, small cell carcinoma pulmonary type, and large cell neuroendocrine carcinoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002481"
    },
    {
      "id": 6787,
      "label": "large cell neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        6943
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050872",
          "EFO:0000563",
          "GARD:0024145",
          "ICDO:8013/3",
          "MEDGEN:220402",
          "NCIT:C6875",
          "ONCOTREE:LUNE",
          "UMLS:C1265996",
          "icd11.foundation:1278312485"
        ],
        "synonyms": [
          "LCNEC",
          "large cell NEC",
          "large cell neuroendocrine carcinoma",
          "large-cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005057"
    },
    {
      "id": 6864,
      "label": "ovarian carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4001",
          "EFO:0001075",
          "GARD:0024154",
          "MEDGEN:1648335",
          "NCIT:C4908",
          "UMLS:C4721610"
        ],
        "synonyms": [
          "ovarian cancer",
          "ovarian epithelial cancer",
          "carcinoma of ovary",
          "carcinoma of the ovary",
          "epithelial ovarian cancer",
          "ovarian carcinoma",
          "ovary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002"
      },
      "child_count": 9,
      "reference_id": "MONDO:0005140"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4561,
      "label": "ovarian neuroendocrine neoplasm"
    },
    {
      "id": 6787,
      "label": "large cell neuroendocrine carcinoma"
    },
    {
      "id": 6864,
      "label": "ovarian carcinoma"
    }
  ]
}