{
  "id": 5040,
  "label": "lung large cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003050",
  "properties": {
    "xrefs": [
      "DOID:4556",
      "EFO:0003050",
      "ICD9:162.9",
      "MEDGEN:91060",
      "NCIT:C4450",
      "ONCOTREE:LCLC",
      "SCTID:254629004",
      "UMLS:C0345958"
    ],
    "synonyms": [
      "anaplastic lung carcinoma",
      "large cell carcinoma of lung",
      "large cell carcinoma of the lung",
      "large cell lung cancer",
      "large cell lung carcinoma",
      "large cell undifferentiated lung carcinoma",
      "lung large cell carcinoma",
      "LCLC"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A poorly differentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular or squamous differentiation. There is a male predilection."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6943,
      "label": "large cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4552",
          "ICDO:8012/3",
          "MEDGEN:61665",
          "MESH:D018287",
          "NCIT:C3780",
          "UMLS:C0206704"
        ],
        "synonyms": [
          "carcinoma, large cell",
          "large cell carcinoma"
        ],
        "definition": "A malignant epithelial neoplasm composed of large, atypical cells."
      },
      "child_count": 5,
      "reference_id": "MONDO:0005232"
    },
    {
      "id": 6944,
      "label": "non-small cell lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6862
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3908",
          "EFO:0003060",
          "HP:0030358",
          "MEDGEN:40104",
          "MESH:D002289",
          "NCIT:C2926",
          "ONCOTREE:NSCLC",
          "Orphanet:488201",
          "SCTID:254637007",
          "UMLS:C0007131"
        ],
        "synonyms": [
          "NSCLC",
          "NSCLC - non-small cell lung cancer",
          "non-small cell cancer of lung",
          "non-small cell cancer of the lung",
          "non-small cell carcinoma of lung",
          "non-small cell carcinoma of the lung",
          "non-small cell lung cancer",
          "non-small cell lung carcinoma",
          "non-small cell lung carcinoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005233"
    }
  ],
  "children": [
    {
      "id": 5818,
      "label": "pulmonary large cell neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5040,
        6787,
        7117
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6658",
          "GARD:0023754",
          "MEDGEN:233608",
          "NCIT:C5672",
          "UMLS:C1334363"
        ],
        "synonyms": [
          "LCNEC of the lung",
          "large cell lung carcinoma with neuroendocrine differentiation",
          "large cell lung neuroendocrine carcinoma",
          "large cell neuroendocrine carcinoma of lung",
          "large cell neuroendocrine carcinoma of the lung",
          "lung large cell neuroendocrine carcinoma",
          "pulmonary large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A large cell neuroendocrine carcinoma that involves the lung(s)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003960"
    },
    {
      "id": 5922,
      "label": "basaloid large cell lung carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5040,
        7673
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7045",
          "MEDGEN:231419",
          "NCIT:C7266",
          "ONCOTREE:BLCLC",
          "UMLS:C1332463"
        ],
        "synonyms": [
          "basaloid large cell lung carcinoma",
          "basaloid large cell carcinoma of the lung",
          "basaloid lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A morphologic variant of large cell lung carcinoma characterized by the presence of a solid nodular or anastomotic trabecular growth pattern, peripheral palisading, and comedo type necrosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004087"
    },
    {
      "id": 5957,
      "label": "lung occult large cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5040
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7169",
          "MEDGEN:235399",
          "NCIT:C6685",
          "UMLS:C1335095"
        ],
        "synonyms": [
          "occult large cell carcinoma of the lung",
          "occult large cell carcinoma of lung",
          "occult large cell lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A large cell lung carcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004128"
    },
    {
      "id": 6058,
      "label": "large cell carcinoma with rhabdoid phenotype",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5040
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7480",
          "ICDO:8014/3",
          "MEDGEN:226828",
          "NCIT:C6876",
          "ONCOTREE:RLCLC",
          "UMLS:C1265997"
        ],
        "synonyms": [
          "large cell carcinoma with rhabdoid phenotype (morphologic abnormality)",
          "large cell lung carcinoma with rhabdoid phenotype",
          "RLCLC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare poorly differentiated morphologic variant of large cell lung carcinoma characterized by the presence of rhabdoid cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004237"
    },
    {
      "id": 7822,
      "label": "lung sarcomatoid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5040,
        7925
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080777",
          "EFO:1000336",
          "ICD9:162.9",
          "MEDGEN:353871",
          "NCIT:C45540",
          "ONCOTREE:SARCL",
          "SCTID:707460002",
          "UMLS:C1708781"
        ],
        "synonyms": [
          "lung sarcomatoid carcinoma",
          "sarcomatoid carcinoma of the lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare, aggressive, poorly differentiated, non-small cell lung carcinoma characterized by the presence of a sarcomatoid component often associated with giant cell differentiation. There is a male to female ratio of 4:1. Clinical symptoms include cough, hemoptysis, chest pain, progressive dyspnea and fever secondary to recurrent pneumonia. Cigarette smoking is a major risk factor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0006279"
    },
    {
      "id": 7826,
      "label": "lymphoepithelioma-like lung carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5040
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000340",
          "MEDGEN:313374",
          "NCIT:C45519",
          "ONCOTREE:LECLC",
          "UMLS:C1708792"
        ],
        "synonyms": [
          "lymphoepithelioma-like carcinoma of the lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A morphologic variant of large cell lung carcinoma characterized by the presence of a syncytial growth pattern, large vesicular nuclei with esophnophilic nucleoi, and dense lymphoplasmacytic infiltration."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006283"
    },
    {
      "id": 21392,
      "label": "large cell lung carcinoma, clear cell variant",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5040
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:317518",
          "NCIT:C4451",
          "ONCOTREE:CCLC",
          "UMLS:C1707407"
        ],
        "synonyms": [
          "clear cell carcinoma of lung, large cell type",
          "clear cell carcinoma of the lung, large cell type",
          "clear cell lung carcinoma, large cell type",
          "large cell lung carcinoma, clear cell variant",
          "clear cell carcinoma of the lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A morphologic variant of large cell lung carcinoma characterized by a predominance of clear cells that may or may not contain glycogen."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024386"
    }
  ],
  "roots": [
    {
      "id": 6943,
      "label": "large cell carcinoma"
    },
    {
      "id": 6944,
      "label": "non-small cell lung carcinoma"
    }
  ]
}