{
  "id": 5061,
  "label": "trilateral retinoblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003073",
  "properties": {
    "xrefs": [
      "DOID:4647",
      "GARD:0023353",
      "MEDGEN:392856",
      "NCIT:C7019",
      "UMLS:C2608045"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "Trilateral retinoblastoma refers to bilateral (or less often unilateral) retinoblastoma associated with an intracranial primitive neuroectodermal tumor in the pineal or suprasellar region. This syndrome is often associated with a increased familial incidence of retinoblastoma. (From Cancer 86(1): 135-141, 1999)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 9679,
      "label": "retinoblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6154
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:768",
          "GARD:0007563",
          "ICDO:9510/3",
          "MEDGEN:20552",
          "MESH:D012175",
          "MedDRA:10038916",
          "NANDO:2200042",
          "NCIT:C7541",
          "ONCOTREE:RBL",
          "Orphanet:790",
          "SCTID:370967009",
          "UMLS:C0035335",
          "icd11.foundation:1855353671"
        ],
        "synonyms": [
          "RB",
          "retinoblastoma",
          "retinoblastoma, malignant",
          "RB1",
          "Rb",
          "eye cancer, retinoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma."
      },
      "child_count": 7,
      "reference_id": "MONDO:0008380"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 9679,
      "label": "retinoblastoma"
    }
  ]
}