{
  "id": 5064,
  "label": "intraocular retinoblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003077",
  "properties": {
    "xrefs": [
      "DOID:4653",
      "GARD:0023356",
      "MEDGEN:78874",
      "NCIT:C7846",
      "UMLS:C0278717"
    ],
    "synonyms": [
      "intraocular retinoblastoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "Retinoblastoma restricted to local involvement."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 9679,
      "label": "retinoblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6154
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:768",
          "GARD:0007563",
          "ICDO:9510/3",
          "MEDGEN:20552",
          "MESH:D012175",
          "MedDRA:10038916",
          "NANDO:2200042",
          "NCIT:C7541",
          "ONCOTREE:RBL",
          "Orphanet:790",
          "SCTID:370967009",
          "UMLS:C0035335",
          "icd11.foundation:1855353671"
        ],
        "synonyms": [
          "RB",
          "retinoblastoma",
          "retinoblastoma, malignant",
          "RB1",
          "Rb",
          "eye cancer, retinoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma."
      },
      "child_count": 7,
      "reference_id": "MONDO:0008380"
    }
  ],
  "children": [
    {
      "id": 5886,
      "label": "pediatric intraocular retinoblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5064,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6938",
          "GARD:0023789",
          "MEDGEN:230836",
          "NCIT:C9047",
          "UMLS:C1321869"
        ],
        "synonyms": [
          "intraocular retinoblastoma",
          "childhood intraocular retinoblastoma",
          "intraocular retinoblastoma of childhood",
          "pediatric intraocular retinoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Retinoblastoma during childhood that has not spread beyond the eye."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004045"
    }
  ],
  "roots": [
    {
      "id": 9679,
      "label": "retinoblastoma"
    }
  ]
}