{
  "id": 5076,
  "label": "extrahepatic bile duct carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003090",
  "properties": {
    "xrefs": [
      "DOID:4682",
      "GARD:0023363",
      "MEDGEN:116036",
      "NCIT:C3860",
      "SCTID:372101000",
      "UMLS:C0238019"
    ],
    "synonyms": [
      "carcinoma of extrahepatic bile duct",
      "carcinoma of the extrahepatic bile duct",
      "extrahepatic bile duct cancer",
      "extrahepatic bile duct carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from epithelial cells of the extrahepatic bile duct."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 7152,
      "label": "bile duct carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5049,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4897",
          "EFO:0005540",
          "GARD:0024194",
          "MEDGEN:152840",
          "NCIT:C27814",
          "UMLS:C0740277"
        ],
        "synonyms": [
          "bile duct cancer",
          "bile duct cancer (including cholangiocarcinoma)",
          "bile duct carcinoma",
          "carcinoma of bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the bile duct"
      },
      "child_count": 8,
      "reference_id": "MONDO:0005496"
    },
    {
      "id": 20500,
      "label": "malignant tumor of extrahepatic bile duct",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5049,
        20541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025312",
          "ICD10CM:C24.0",
          "ICD9:156.1",
          "ICD9:156.8",
          "MEDGEN:56304",
          "NCIT:C7483",
          "SCTID:363416002",
          "UMLS:C0153453"
        ],
        "synonyms": [
          "extrahepatic bile duct cancer",
          "cancer of extrahepatic bile duct",
          "malignant extrahepatic bile duct neoplasm",
          "malignant extrahepatic bile duct tumor",
          "malignant extrahepatic bile duct tumour",
          "malignant neoplasm of extrahepatic bile duct",
          "malignant neoplasm of the extrahepatic bile duct",
          "malignant tumor of the extrahepatic bile duct",
          "malignant tumour of the extrahepatic bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A cancer that involves the extrahepatic bile duct."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021321"
    }
  ],
  "children": [
    {
      "id": 4714,
      "label": "extrahepatic bile duct adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5076,
        5152
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3495",
          "GARD:0023205",
          "MEDGEN:124642",
          "NCIT:C7975",
          "UMLS:C0279659"
        ],
        "synonyms": [
          "adenocarcinoma of extrahepatic bile duct",
          "adenocarcinoma of the extrahepatic bile duct",
          "extrahepatic bile duct adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the extrahepatic bile duct"
      },
      "child_count": 14,
      "reference_id": "MONDO:0002665"
    },
    {
      "id": 5311,
      "label": "extrahepatic bile duct leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5076,
        5312,
        21565
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5293",
          "GARD:0023489",
          "MEDGEN:232481",
          "NCIT:C5848",
          "UMLS:C1333508"
        ],
        "synonyms": [
          "bile duct leiomyosarcoma",
          "extrahepatic bile duct leiomyosarcoma",
          "leiomyosarcoma of bile duct",
          "leiomyosarcoma of extrahepatic bile duct",
          "leiomyosarcoma of the bile duct",
          "leiomyosarcoma of the extrahepatic bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm, arising from an extrahepatic bile duct. It is characterized by a proliferation of neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003377"
    },
    {
      "id": 5589,
      "label": "distal biliary tract carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5076
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5923",
          "GARD:0023627",
          "MEDGEN:232133",
          "NCIT:C7109",
          "UMLS:C1333308"
        ],
        "synonyms": [
          "carcinoma of distal biliary tract",
          "distal bile duct cancer",
          "distal bile duct carcinoma",
          "extrahepatic (distal) bile duct cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the common bile duct distal to the insertion of the cystic duct."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003707"
    },
    {
      "id": 7758,
      "label": "extrahepatic bile duct squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5076,
        5414
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000248",
          "GARD:0024328",
          "NCIT:C5777"
        ],
        "synonyms": [
          "bile duct squamous cell carcinoma",
          "squamous cell bile duct carcinoma",
          "squamous cell carcinoma of bile duct",
          "squamous cell carcinoma of the bile duct",
          "extrahepatic bile duct squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the extrahepatic bile ducts. It is composed entirely by malignant squamous epithelial cells."
      },
      "child_count": 6,
      "reference_id": "MONDO:0006203"
    },
    {
      "id": 17870,
      "label": "carcinoma of the ampulla of vater",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3189,
        5076,
        20511
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4932",
          "EFO:1000079",
          "GARD:0021237",
          "MEDGEN:120461",
          "MedDRA:10048853",
          "NCIT:C3908",
          "ONCOTREE:AMPCA",
          "Orphanet:300557",
          "SCTID:254609000",
          "UMLS:C0262401",
          "icd11.foundation:267067189"
        ],
        "synonyms": [
          "Ampulloma",
          "ampulla of Vater cancer",
          "ampulla of Vater carcinoma",
          "ampullary cancer",
          "ampullary carcinoma",
          "carcinoma of ampulla of vater",
          "carcinoma of hepatopancreatic ampulla",
          "hepatopancreatic ampulla carcinoma",
          "AMPCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
      },
      "child_count": 9,
      "reference_id": "MONDO:0017590"
    },
    {
      "id": 20487,
      "label": "carcinoma in situ of extrahepatic bile duct",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2873,
        5076
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025309",
          "MEDGEN:138028",
          "NCIT:C4442",
          "SCTID:92589000",
          "UMLS:C0345914"
        ],
        "synonyms": [
          "carcinoma in situ of extrahepatic bile duct",
          "carcinoma in situ of extrahepatic bile ducts",
          "carcinoma in situ of extrahepatic biliary ducts",
          "carcinoma in situ of the extrahepatic bile duct",
          "extrahepatic bile duct cancer stage 0",
          "extrahepatic bile duct carcinoma in situ",
          "extrahepatic bile duct in situ carcinoma",
          "extrahepatic biliary duct carcinoma in situ",
          "stage 0 carcinoma of extrahepatic bile duct",
          "stage 0 carcinoma of the extrahepatic bile duct",
          "stage 0 extrahepatic bile duct cancer",
          "stage 0 extrahepatic bile duct carcinoma",
          "stage 0 extrahepatic bile duct carcinoma in situ"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A in situ carcinoma that involves the extrahepatic bile duct."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021299"
    }
  ],
  "roots": [
    {
      "id": 7152,
      "label": "bile duct carcinoma"
    },
    {
      "id": 20500,
      "label": "malignant tumor of extrahepatic bile duct"
    }
  ]
}