{
  "id": 5101,
  "label": "testicular Leydig cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003124",
  "properties": {
    "xrefs": [
      "DOID:4756",
      "GARD:0023375",
      "MEDGEN:163584",
      "NCIT:C6356",
      "SCTID:67871000119105",
      "UMLS:C0863027"
    ],
    "synonyms": [
      "Leydig cell neoplasm of testis",
      "Leydig cell neoplasm of the testis",
      "Leydig cell tumor of testis",
      "Leydig cell tumour of testis",
      "testicular Leydig cell neoplasm",
      "testicular Leydig cell tumor",
      "testis Leydig cell tumor",
      "testis Leydig cell tumour",
      "Leydig cell tumor of the testis",
      "Leydig cell tumour of the testis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A sex cord-stromal tumor that arises from the testis and is characterized by the presence of cells that resemble the successive stages of development of Leydig cells. It usually presents as a painless testicular mass. Gynecomastia is present in approximately thirty percent of the cases. Libido may be decreased. In children, precocious puberty may be present. A minority of cases exhibit malignant characteristics."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 5102,
      "label": "testicular sex cord-stromal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639,
        20517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4757",
          "GARD:0021551",
          "MEDGEN:825921",
          "NCIT:C6358",
          "Orphanet:363489",
          "SCTID:702406000",
          "UMLS:C3840076"
        ],
        "synonyms": [
          "sex cord-stromal tumor of testis",
          "sex cord-stromal tumour of testis",
          "testicular sex cord-stromal neoplasm",
          "testicular sex cord-stromal tumor",
          "testicular sex cord-stromal tumour",
          "testis sex cord-stromal tumor",
          "testis sex cord-stromal tumour",
          "sex cord-stromal neoplasm",
          "sex cord-stromal neoplasm of testis",
          "sex cord-stromal neoplasm of the testis",
          "sex cord-stromal tumor of the testis",
          "sex cord-stromal tumour of the testis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant tumor that arises from the testis. It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the tumor or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, ten percent of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group."
      },
      "child_count": 20,
      "reference_id": "MONDO:0003125"
    },
    {
      "id": 7810,
      "label": "Leydig cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2696",
          "EFO:1000321",
          "ICDO:8650/1",
          "MEDGEN:9747",
          "MESH:D007984",
          "NCIT:C3188",
          "UMLS:C0023601"
        ],
        "synonyms": [
          "Leydig cell neoplasm",
          "Leydig cell tumor",
          "interstitial cell neoplasm",
          "interstitial cell tumor",
          "interstitial cell tumour",
          "Leydig cell tumor, undetermined"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A sex cord-stromal tumor occurring in the testis and rarely in the ovary. It is predominantly or completely composed of Leydig cells which may contain crystals of Reinke. In males it usually presents as a painless testicular enlargement and it may be associated with gynecomastia and decreased libido. The majority of the cases have a benign clinical course. Approximately 10% of the cases have a malignant clinical course and metastasize. In females it may be associated with androgenic manifestations and it follows a benign clinical course."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006266"
    }
  ],
  "children": [
    {
      "id": 5617,
      "label": "malignant testicular Leydig cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2876,
        5101,
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6021",
          "GARD:0023641",
          "MEDGEN:271769",
          "NCIT:C39942",
          "UMLS:C1515288"
        ],
        "synonyms": [
          "testicular Leydig cell tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A Leydig cell tumor characterized by a large size, cellular atypia, high mitotic activity, vascular invasion and necrotic changes. The prognosis is usually poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003737"
    }
  ],
  "roots": [
    {
      "id": 5102,
      "label": "testicular sex cord-stromal neoplasm"
    },
    {
      "id": 7810,
      "label": "Leydig cell tumor"
    }
  ]
}