{
  "id": 5102,
  "label": "testicular sex cord-stromal neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003125",
  "properties": {
    "xrefs": [
      "DOID:4757",
      "GARD:0021551",
      "MEDGEN:825921",
      "NCIT:C6358",
      "Orphanet:363489",
      "SCTID:702406000",
      "UMLS:C3840076"
    ],
    "synonyms": [
      "sex cord-stromal tumor of testis",
      "sex cord-stromal tumour of testis",
      "testicular sex cord-stromal neoplasm",
      "testicular sex cord-stromal tumor",
      "testicular sex cord-stromal tumour",
      "testis sex cord-stromal tumor",
      "testis sex cord-stromal tumour",
      "sex cord-stromal neoplasm",
      "sex cord-stromal neoplasm of testis",
      "sex cord-stromal neoplasm of the testis",
      "sex cord-stromal tumor of the testis",
      "sex cord-stromal tumour of the testis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A benign or malignant tumor that arises from the testis. It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the tumor or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, ten percent of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 7639,
      "label": "sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:192",
          "EFO:1000052",
          "ICDO:8590/1",
          "MEDGEN:104926",
          "NANDO:2200072",
          "NCIT:C3794",
          "UMLS:C0206724"
        ],
        "synonyms": [
          "Sex cord stromal tumor",
          "Sex cord-stromal neoplasm",
          "Sex cord-stromal tumor",
          "Sex cord-stromal tumor, no ICD-O subtype",
          "Sex cord-stromal tumor, no ICD-O subtype (morphologic abnormality)",
          "Sex cord-stromal tumour",
          "neoplasm of sex cord",
          "sex cord neoplasm",
          "sex cord tumor",
          "sex cord tumour",
          "sex cord-stromal tumor",
          "specialised gonadal neoplasm",
          "specialised gonadal neoplasm (morphologic abnormality)",
          "specialised gonadal neoplasm NOS (morphologic abnormality)",
          "specialised gonadal tumour",
          "specialised gonadal tumour (qualifier value)",
          "specialized gonadal neoplasm (morphologic abnormality)",
          "specialized gonadal neoplasm NOS (morphologic abnormality)",
          "specialized gonadal tumor (qualifier value)",
          "tumor of sex cord",
          "tumour of sex cord",
          "malignant testicular sex cord-stromal tumor",
          "malignant testicular sex cord-stromal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A neoplasm involving a sex cord."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006055"
    },
    {
      "id": 20517,
      "label": "neoplasm of testis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4435,
        21521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:239.5",
          "MEDGEN:52675",
          "NCIT:C3404",
          "ONCOTREE:TESTIS",
          "SCTID:126900000",
          "UMLS:C0039590"
        ],
        "synonyms": [
          "neoplasm of testis",
          "neoplasm of the testis",
          "testicular neoplasm",
          "testicular tumor",
          "testicular tumour",
          "testis neoplasm",
          "testis neoplasm (disease)",
          "testis tumor",
          "testis tumour",
          "tumor of testis",
          "tumor of the testis",
          "tumour of testis",
          "tumour of the testis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the testis."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021348"
    }
  ],
  "children": [
    {
      "id": 3686,
      "label": "testicular lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5102,
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12253",
          "GARD:0022950",
          "ICD9:186.9",
          "MEDGEN:138110",
          "NCIT:C6810",
          "ONCOTREE:TLYM",
          "SCTID:277664004",
          "UMLS:C0349644"
        ],
        "synonyms": [
          "lymphoma of testis",
          "lymphoma of the testis",
          "primary testicular lymphoma",
          "testicular lymphoma",
          "TLYM"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A lymphoma that arises from the testis and is not associated with lymphoma in another anatomic site."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001472"
    },
    {
      "id": 4559,
      "label": "Sertoli-Leydig cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5102
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2997",
          "GARD:0009967",
          "MEDGEN:61669",
          "MESH:D018310",
          "ONCOTREE:SLCT",
          "UMLS:C0206723"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A sex cord-gonadal stromal tumor consists of leydig cells; sertoli cells; and fibroblasts in varying proportions and degree of differentiation. Most such tumors produce androgens in the Leydig cells, formerly known as androblastoma or arrhenoblastoma. Androblastomas occur in the testis or the ovary causing precocious masculinization in the males, and defeminization, or virilization (virilism) in the females. In some cases, the Sertoli cells produce estrogens."
      },
      "child_count": 1,
      "reference_id": "MONDO:0002479"
    },
    {
      "id": 4742,
      "label": "testicular gonadoblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5102,
        7111,
        11906
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3579",
          "GARD:0023215",
          "HP:0000030",
          "MEDGEN:272839",
          "NCIT:C39911",
          "UMLS:C1515283"
        ],
        "synonyms": [
          "gonadoblastoma of testis",
          "testicular gonadoblastoma",
          "testicular gonadoblastoma (disease)",
          "testis gonadoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A testicular mixed germ cell-sex cord-stromal tumor. It is usually associated with mixed gonadal dysgenesis and ambiguous genitalia. It is characterized by the presence of nests of large neoplastic germ cells and immature cells that resemble Sertoli cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002698"
    },
    {
      "id": 5101,
      "label": "testicular Leydig cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5102,
        7810
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4756",
          "GARD:0023375",
          "MEDGEN:163584",
          "NCIT:C6356",
          "SCTID:67871000119105",
          "UMLS:C0863027"
        ],
        "synonyms": [
          "Leydig cell neoplasm of testis",
          "Leydig cell neoplasm of the testis",
          "Leydig cell tumor of testis",
          "Leydig cell tumour of testis",
          "testicular Leydig cell neoplasm",
          "testicular Leydig cell tumor",
          "testis Leydig cell tumor",
          "testis Leydig cell tumour",
          "Leydig cell tumor of the testis",
          "Leydig cell tumour of the testis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A sex cord-stromal tumor that arises from the testis and is characterized by the presence of cells that resemble the successive stages of development of Leydig cells. It usually presents as a painless testicular mass. Gynecomastia is present in approximately thirty percent of the cases. Libido may be decreased. In children, precocious puberty may be present. A minority of cases exhibit malignant characteristics."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003124"
    },
    {
      "id": 5327,
      "label": "testicular granulosa cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5102,
        7622
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5331",
          "GARD:0023498",
          "MEDGEN:237001",
          "NCIT:C6357",
          "UMLS:C1336709"
        ],
        "synonyms": [
          "granulosa cell tumor of testis",
          "testicular granulosa cell tumor",
          "testis granulosa cell tumor",
          "testis granulosa cell tumour",
          "granulosa cell neoplasm of testis",
          "granulosa cell neoplasm of the testis",
          "granulosa cell tumor of the testis",
          "granulosa cell tumour of the testis",
          "testicular granulosa cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare sex cord-stromal tumor that arises from the testis. It is characterized by the presence of granulosa-like cells and Call-Exner bodies. There are two variants described, the adult and the juvenile."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003395"
    },
    {
      "id": 6140,
      "label": "testicular fibroma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5102,
        6889
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7675",
          "GARD:0023936",
          "MEDGEN:308256",
          "NCIT:C39951",
          "UMLS:C1515282"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign neoplasm that arises from the testis and is characterized by the presence of fusiform cells and collagenization."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004324"
    },
    {
      "id": 6141,
      "label": "testicular thecoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5102,
        22960
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7676",
          "GARD:0023937",
          "MEDGEN:308260",
          "NCIT:C39952",
          "UMLS:C1515299"
        ],
        "synonyms": [
          "testis thecoma",
          "thecoma of testis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare benign tumor that arises from the testis and is characterized by the presence of lipid-rich neoplastic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004325"
    },
    {
      "id": 20205,
      "label": "testicular sertoli cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4740,
        5102
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025254",
          "MEDGEN:91165",
          "NCIT:C4672",
          "UMLS:C0349671"
        ],
        "synonyms": [
          "Sertoli Cell Neoplasm of Testis",
          "Sertoli Cell Neoplasm of the Testis",
          "Sertoli Cell Tumor of Testis",
          "Sertoli Cell Tumor of the Testis",
          "Sertoli Cell Tumour of Testis",
          "Sertoli Cell Tumour of the Testis",
          "Testicular Sertoli Cell Neoplasm",
          "Testicular Sertoli Cell Tumor",
          "Testicular Sertoli Cell Tumor, NOS",
          "Testicular Sertoli Cell Tumor, Not Otherwise Specified",
          "Testicular Sertoli Cell Tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A sex cord-stromal tumor that arises from the testis and is characterized by the presence of neoplastic cells with features of Sertoli cells. It usually presents as a slow growing testicular mass. The vast majority of cases follow a benign clinical course."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020808"
    },
    {
      "id": 24435,
      "label": "testicular fibrothecoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5102,
        24434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026332"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare testicular sex cord-stromal neoplasm characterized by mixed features of both fibroma and thecoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0700037"
    },
    {
      "id": 25154,
      "label": "testicular sex cord-stromal benign neoplasm",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5102
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080371",
          "GARD:0026579"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A sex cord-stromal benign neoplasm that arises from the testis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850126"
    }
  ],
  "roots": [
    {
      "id": 7639,
      "label": "sex cord-stromal tumor"
    },
    {
      "id": 20517,
      "label": "neoplasm of testis"
    }
  ]
}