{
  "id": 5128,
  "label": "vascular hemostatic disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003159",
  "properties": {
    "xrefs": [
      "DOID:484",
      "GARD:0023389",
      "MEDGEN:154721",
      "MESH:D020141",
      "SCTID:21112004",
      "UMLS:C0600502"
    ],
    "synonyms": [
      "disorder, vascular hemostatic",
      "disorders, vascular hemostatic",
      "hemostatic disorder",
      "hemostatic disorder, vascular",
      "hemostatic disorders, vascular",
      "vascular hemostatic disorder",
      "vascular hemostatic disorders"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of blood vessels, blood fluidity, and blood coagulation. Majority of the hemostatic disorders are caused by disruption of the normal interaction between the vascular endothelium, the plasma proteins (including blood coagulation factors), and platelets."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4360,
      "label": "hemorrhagic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2213",
          "ICD9:287.9",
          "MEDGEN:6799",
          "MESH:D006474",
          "NCIT:C115221",
          "UMLS:C0019087"
        ],
        "synonyms": [
          "bleeding diathesis",
          "bleeding disorder",
          "bleeding predisposition",
          "bleeding tendency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (blood coagulation disorders) or another abnormality causing a structural flaw in the blood vessels (hemostatic disorders)."
      },
      "child_count": 28,
      "reference_id": "MONDO:0002243"
    },
    {
      "id": 7065,
      "label": "vascular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:178",
          "EFO:0004264",
          "ICD10CM:I00-I99",
          "ICD10CM:I70-I79",
          "ICD9:442.9",
          "MEDGEN:22621",
          "MESH:D014652",
          "NANDO:2100294",
          "NCIT:C35117",
          "SCTID:27550009",
          "UMLS:C0042373"
        ],
        "synonyms": [
          "disease of vasculature",
          "disease or disorder of vasculature",
          "disorder of vasculature",
          "vascular disorder",
          "vasculature disease",
          "vasculature disease or disorder",
          "vasculopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005385"
    }
  ],
  "children": [
    {
      "id": 4812,
      "label": "Shwartzman phenomenon",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5128,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3825",
          "GARD:0007636",
          "MEDGEN:48656",
          "MESH:D012790",
          "UMLS:C0037018"
        ],
        "synonyms": [
          "Shwartzman reaction (function)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (endotoxins) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous thrombosis and necrosis. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of immune system, coagulation, fibrinolysis, and blood flow."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002783"
    },
    {
      "id": 5125,
      "label": "cavernous hemangioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4440,
        5128,
        7994
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:483",
          "EFO:1000151",
          "GARD:0023388",
          "HP:0001048",
          "ICDO:9121/0",
          "MEDGEN:9184",
          "MESH:D006392",
          "NCIT:C3086",
          "SCTID:416824008",
          "UMLS:C0018920"
        ],
        "synonyms": [
          "cavernoma",
          "cavernous angioma",
          "cavernous hemangioma",
          "cavernous hemangioma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A hemangioma characterized by the presence of cavernous vascular spaces."
      },
      "child_count": 21,
      "reference_id": "MONDO:0003155"
    }
  ],
  "roots": [
    {
      "id": 4360,
      "label": "hemorrhagic disease"
    },
    {
      "id": 7065,
      "label": "vascular disorder"
    }
  ]
}