{
  "id": 5139,
  "label": "salivary gland adenoid cystic carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003175",
  "properties": {
    "xrefs": [
      "DOID:4866",
      "GARD:0023398",
      "MEDGEN:79034",
      "NCIT:C8026",
      "SCTID:422833009",
      "UMLS:C0279751"
    ],
    "synonyms": [
      "adenoid cystic cancer",
      "adenoid cystic carcinoma (morphologic abnormality)",
      "adenoid cystic carcinoma of salivary gland",
      "adenoid cystic carcinoma of the salivary gland",
      "cylindroma (morphologic abnormality)",
      "saliva-secreting gland adenoid cystic carcinoma",
      "salivary gland adenoid cystic cancer",
      "salivary gland adenoid cystic carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0006858",
        "name": "mouth disorder"
      }
    ],
    "definition": "An adenoid cystic carcinoma arising from the salivary gland. It is characterized by the presence of epithelial and myoepithelial cells forming tubular, cribriform, and solid patterns. It usually presents as a slow growing mass. Patients may experience pain because of the tumor propensity for perineural invasion. The tumor may follow an aggressive clinical course with recurrences and mestastases to distant sites including lungs, bones, brain, and liver."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 2972,
      "label": "salivary gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6453,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050904",
          "GARD:0027535",
          "MEDGEN:215302",
          "NANDO:2200076",
          "NCIT:C9272",
          "ONCOTREE:SACA",
          "UMLS:C0948750"
        ],
        "synonyms": [
          "salivary gland cancer",
          "carcinoma of saliva-secreting gland",
          "carcinoma of salivary gland",
          "carcinoma of the salivary gland",
          "saliva-secreting gland carcinoma",
          "salivary gland carcinoma",
          "salivary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma that arises from the major or minor salivary glands. Representative examples include carcinoma ex pleomorphic adenoma, adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0000521"
    },
    {
      "id": 6713,
      "label": "adenoid cystic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080202",
          "EFO:0000231",
          "GARD:0005743",
          "ICDO:8200/3",
          "MEDGEN:41382",
          "MESH:D003528",
          "NCIT:C2970",
          "ONCOTREE:ACYC",
          "UMLS:C0010606",
          "icd11.foundation:2127202862"
        ],
        "synonyms": [
          "adenocystic carcinoma",
          "adenoid cystic cancer",
          "adenoid cystic carcinoma",
          "cylindroid adenocarcinoma",
          "cribriform carcinoma",
          "cylindroma"
        ],
        "definition": "A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic."
      },
      "child_count": 17,
      "reference_id": "MONDO:0004971"
    }
  ],
  "children": [
    {
      "id": 23547,
      "label": "major salivary gland adenoid cystic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5139,
        7827
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025941",
          "MEDGEN:235286",
          "NCIT:C5905",
          "UMLS:C1334548"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of major salivary gland",
          "adenoid cystic carcinoma of the major salivary gland",
          "major salivary gland adenoid cystic cancer",
          "major salivary gland adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "An aggressive carcinoma that arises from the major salivary glands. It is characterized by the presence of malignant epithelial and myoepithelial cells forming cribriform, tubular, and solid patterns. It usually presents as a slow growing mass. Patients develop pain because of the tendency of these carcinomas to invade perineural tissues."
      },
      "child_count": 6,
      "reference_id": "MONDO:0045063"
    },
    {
      "id": 23548,
      "label": "minor salivary gland adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5139,
        7843
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025942",
          "MEDGEN:233709",
          "NCIT:C5936",
          "UMLS:C1334769"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of minor salivary gland",
          "adenoid cystic carcinoma of the minor salivary gland",
          "minor salivary gland adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "An aggressive carcinoma that arises from the minor salivary glands. It is characterized by the presence of malignant epithelial and myoepithelial cells forming cribriform, tubular, and solid patterns. It usually presents as a slow growing mass."
      },
      "child_count": 0,
      "reference_id": "MONDO:0045068"
    }
  ],
  "roots": [
    {
      "id": 2972,
      "label": "salivary gland carcinoma"
    },
    {
      "id": 6713,
      "label": "adenoid cystic carcinoma"
    }
  ]
}