{
  "id": 5143,
  "label": "anterior horn disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003182",
  "properties": {
    "xrefs": [
      "DOID:4873",
      "ICD9:335",
      "MEDGEN:102314",
      "SCTID:85672005",
      "UMLS:C0154681"
    ],
    "synonyms": [
      "disease of ventral horn of spinal cord",
      "disease or disorder of ventral horn of spinal cord",
      "disorder of ventral horn of spinal cord",
      "ventral horn of spinal cord disease",
      "ventral horn of spinal cord disease or disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Anterior horn disease is one of a number of medical disorders affecting the anterior horn of the spinal cord. Anterior horn diseases include spinal muscular atrophy, poliomyelitis and amyotrophic lateral sclerosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4611,
      "label": "spinal cord disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:319",
          "EFO:0009488",
          "ICD9:336.8",
          "ICD9:336.9",
          "MEDGEN:11550",
          "MESH:D013118",
          "NCIT:C97110",
          "SCTID:48522003",
          "UMLS:C0037928"
        ],
        "synonyms": [
          "disease of spinal cord",
          "disease of the spinal cord",
          "disease or disorder of spinal cord",
          "disorder of spinal cord",
          "spinal cord disease",
          "spinal cord disease or disorder",
          "spinal cord disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease involving the spinal cord."
      },
      "child_count": 10,
      "reference_id": "MONDO:0002545"
    }
  ],
  "children": [
    {
      "id": 3724,
      "label": "spinal muscular atrophy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5143,
        21302
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12377",
          "EFO:0008525",
          "GARD:0007674",
          "ICD9:335.1",
          "ICD9:335.10",
          "ICD9:335.19",
          "MEDGEN:7755",
          "MESH:D009134",
          "NANDO:1200003",
          "NANDO:2100231",
          "NANDO:2200853",
          "NCIT:C85075",
          "OMIMPS:253300",
          "SCTID:5262007",
          "UMLS:C0026847",
          "icd11.foundation:71074342"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A motor neuron disease that affect the muscles, and characterized by muscle weakness and atrophy resulting from progressive degeneration and irreversible loss of the anterior horn cells in the spinal cord (i.e., lower motor neurons) and the brain stem nuclei. The severity of the condition; the associated signs and symptoms; and the age at which symptoms develop varies by subtype. In general, people with spinal muscular atrophy (SMA) experience progressive weakness and atrophy of muscles involved in mobility, the ability to sit unassisted, and head control. Breathing and swallowing may also be affected in severe cases. SMA is generally caused by changes (mutations) in the SMN1 gene and is inherited in an autosomal recessive manner. Extra copies of the SMN2 gene modify the severity of SMA. Rare autosomal dominant (caused by mutations in DYNC1H1, BICD2, or VAPB genes) and X-linked (caused by mutations in UBA1) forms of SMA exist. Treatment is based on the signs and symptoms present in each person."
      },
      "child_count": 38,
      "reference_id": "MONDO:0001516"
    },
    {
      "id": 6718,
      "label": "amyotrophic lateral sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5143,
        19749
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:332",
          "GARD:0005786",
          "HP:0007354",
          "ICD10CM:G12.21",
          "ICD9:335.20",
          "MEDGEN:274",
          "MESH:D000690",
          "MedDRA:10002026",
          "NANDO:1200002",
          "NCIT:C34373",
          "NORD:768",
          "Orphanet:803",
          "SCTID:86044005",
          "UMLS:C0002736",
          "birnlex:12566",
          "icd11.foundation:1982355687"
        ],
        "synonyms": [
          "ALS",
          "Charcot disease",
          "Lou Gehrig disease",
          "amyotrophic lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004976"
    },
    {
      "id": 17684,
      "label": "poliomyelitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4629,
        5143,
        19750,
        20092,
        21351,
        21533
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4953",
          "EFO:0007450",
          "GARD:0007413",
          "ICD9:045",
          "ICD9:045.9",
          "ICD9:045.90",
          "ICD9:045.92",
          "MEDGEN:18545",
          "MESH:D011051",
          "MedDRA:10036012",
          "NCIT:C35550",
          "Orphanet:2912",
          "SCTID:398102009",
          "UMLS:C0032371",
          "icd11.foundation:588527933"
        ],
        "synonyms": [
          "Polia",
          "acute poliomyelitis",
          "polio",
          "poliomyelitis",
          "infantile paralysis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An acute infectious disorder that affects the nervous system. It is caused by the poliovirus. The virus spreads by direct contact, and can be prevented by prophylaxis with the polio vaccine."
      },
      "child_count": 18,
      "reference_id": "MONDO:0017373"
    }
  ],
  "roots": [
    {
      "id": 4611,
      "label": "spinal cord disorder"
    }
  ]
}