{
  "id": 5146,
  "label": "esophageal adenoid cystic carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003186",
  "properties": {
    "xrefs": [
      "DOID:4878",
      "GARD:0023403",
      "MEDGEN:232468",
      "NCIT:C5342",
      "UMLS:C1333441"
    ],
    "synonyms": [
      "adenoid cystic carcinoma of esophagus",
      "adenoid cystic carcinoma of oesophagus",
      "adenoid cystic carcinoma of the esophagus",
      "adenoid cystic carcinoma of the oesophagus",
      "adenoid cystic carcinoma, esophagus",
      "adenoid cystic carcinoma, oesophagus",
      "adenoid cystic esophagus carcinoma",
      "adenoid cystic oesophagus carcinoma",
      "esophageal adenoid cystic cancer",
      "esophageal adenoid cystic carcinoma",
      "esophagus adenoid cystic carcinoma",
      "oesophagus adenoid cystic carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "An infrequent esophageal carcinoma arising from esophageal glands. (WHO)"
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6713,
      "label": "adenoid cystic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080202",
          "EFO:0000231",
          "GARD:0005743",
          "ICDO:8200/3",
          "MEDGEN:41382",
          "MESH:D003528",
          "NCIT:C2970",
          "ONCOTREE:ACYC",
          "UMLS:C0010606",
          "icd11.foundation:2127202862"
        ],
        "synonyms": [
          "adenocystic carcinoma",
          "adenoid cystic cancer",
          "adenoid cystic carcinoma",
          "cylindroid adenocarcinoma",
          "cribriform carcinoma",
          "cylindroma"
        ],
        "definition": "A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic."
      },
      "child_count": 17,
      "reference_id": "MONDO:0004971"
    },
    {
      "id": 6762,
      "label": "esophageal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        18977
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4914",
          "EFO:0000478",
          "GARD:0016927",
          "MEDGEN:124636",
          "NCIT:C4025",
          "ONCOTREE:ESCA",
          "Orphanet:99976",
          "SCTID:276803003",
          "UMLS:C0279628",
          "icd11.foundation:829915640"
        ],
        "synonyms": [
          "adenocarcinoma - esophagus",
          "adenocarcinoma - oesophagus",
          "adenocarcinoma of esophagus",
          "adenocarcinoma of oesophagus",
          "adenocarcinoma of the esophagus",
          "adenocarcinoma of the oesophagus",
          "esophageal adenocarcinoma",
          "esophagus adenocarcinoma",
          "oesophageal adenocarcinoma",
          "oesophagus adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005028"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6713,
      "label": "adenoid cystic carcinoma"
    },
    {
      "id": 6762,
      "label": "esophageal adenocarcinoma"
    }
  ]
}