{
  "id": 5158,
  "label": "anal carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003199",
  "properties": {
    "xrefs": [
      "DOID:4908",
      "GARD:0027634",
      "MEDGEN:76006",
      "NCIT:C9291",
      "SCTID:448315008",
      "UMLS:C0279637"
    ],
    "synonyms": [
      "Ca anus",
      "anal cancer",
      "cancer of anus",
      "cancer of the anus",
      "anal carcinoma",
      "anus carcinoma",
      "carcinoma of anus",
      "carcinoma of the anus"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A carcinoma that arises from epithelial cells of the anus"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4054,
      "label": "anus cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5037,
        8006
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14110",
          "GARD:0009300",
          "ICD9:154.3",
          "MEDGEN:56303",
          "NCIT:C7379",
          "UMLS:C0153446"
        ],
        "synonyms": [
          "anus cancer",
          "cancer of anus",
          "malignant anal neoplasm",
          "malignant anal tumor",
          "malignant anal tumour",
          "malignant anus neoplasm",
          "malignant neoplasm of anus",
          "malignant neoplasm of the anus",
          "malignant tumor of anus",
          "malignant tumor of the anus",
          "malignant tumour of anus",
          "malignant tumour of the anus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the anus"
      },
      "child_count": 8,
      "reference_id": "MONDO:0001879"
    },
    {
      "id": 23485,
      "label": "rectal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8006,
        21360,
        21431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:40100",
          "NCIT:C9382",
          "UMLS:C0007113"
        ],
        "synonyms": [
          "cancer of rectum",
          "cancer of the rectum",
          "rectal cancer",
          "carcinoma of rectum",
          "carcinoma of the rectum",
          "rectal carcinoma",
          "rectum carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant epithelial neoplasm that arises from the rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas."
      },
      "child_count": 18,
      "reference_id": "MONDO:0044937"
    }
  ],
  "children": [
    {
      "id": 4703,
      "label": "anus adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4295,
        5158
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3447",
          "GARD:0027609",
          "MEDGEN:233976",
          "NCIT:C5600",
          "SCTID:423607006",
          "UMLS:C1332257"
        ],
        "synonyms": [
          "adenocarcinoma of anus",
          "adenocarcinoma of the anus",
          "anal adenocarcinoma",
          "anus adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising in the anal canal epithelium, including the mucosal surface, the anal glands, and the lining of fistulous tracts. The prognosis is related to the stage at diagnosis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002652"
    },
    {
      "id": 4946,
      "label": "anal margin carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4707,
        5158
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4284",
          "GARD:0027626",
          "MEDGEN:87604",
          "NCIT:C7472",
          "UMLS:C0349534"
        ],
        "synonyms": [
          "anal margin cancer",
          "anal margin carcinoma",
          "carcinoma of anal margin",
          "carcinoma of perianal skin",
          "carcinoma of the anal margin",
          "perianal skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the perianal skin"
      },
      "child_count": 6,
      "reference_id": "MONDO:0002941"
    },
    {
      "id": 7659,
      "label": "anal squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5158,
        18545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5525",
          "EFO:1000081",
          "GARD:0024286",
          "MEDGEN:237257",
          "NCIT:C9161",
          "ONCOTREE:ANSC",
          "UMLS:C1412036"
        ],
        "synonyms": [
          "anal squamous cell cancer",
          "anal squamous cell carcinoma",
          "anus squamous cell carcinoma",
          "epidermoid anal carcinoma",
          "epidermoid carcinoma of anus",
          "epidermoid carcinoma of the anus",
          "squamous cell anal carcinoma",
          "squamous cell carcinoma - anus",
          "squamous cell carcinoma of anus",
          "squamous cell carcinoma of the anus",
          "ANSC"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006082"
    },
    {
      "id": 8521,
      "label": "anal canal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2895,
        5158,
        18546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6126",
          "GARD:0021772",
          "MEDGEN:107559",
          "NCIT:C7489",
          "OMIM:105580",
          "Orphanet:424013",
          "SCTID:285310000",
          "UMLS:C0563211"
        ],
        "synonyms": [
          "anal canal cancer",
          "anal canal and perianal gland cancer",
          "anal canal and perianal gland carcinoma",
          "anal canal carcinoma",
          "carcinoma of anal canal",
          "carcinoma of the anal canal",
          "cloacogenic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the anal canal"
      },
      "child_count": 15,
      "reference_id": "MONDO:0007108"
    }
  ],
  "roots": [
    {
      "id": 4054,
      "label": "anus cancer"
    },
    {
      "id": 23485,
      "label": "rectal carcinoma"
    }
  ]
}