{
  "id": 5166,
  "label": "intrahepatic cholangiocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003210",
  "properties": {
    "xrefs": [
      "DOID:4928",
      "EFO:1001961",
      "GARD:0006042",
      "ICD10CM:C22.1",
      "MEDGEN:87521",
      "NCIT:C35417",
      "ONCOTREE:IHCH",
      "SCTID:109842005",
      "UMLS:C0345905",
      "icd11.foundation:1253728223",
      "icd11.foundation:387909164"
    ],
    "synonyms": [
      "ICC",
      "cholangiocarcinoma, intrahepatic, malignant",
      "intrahepatic Cholangiocellular carcinoma",
      "intrahepatic bile duct cancer (cholangiocarcinoma)",
      "intrahepatic bile duct carcinoma",
      "intrahepatic carcinoma of bile duct",
      "intrahepatic carcinoma of the bile duct",
      "intrahepatic cholangiocarcinoma",
      "intrahepatic cholangiocarcinoma (bile duct cancer)",
      "IHCH"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 3698,
      "label": "intrahepatic bile duct cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12298",
          "GARD:0022955",
          "ICD9:155.1",
          "MEDGEN:639748",
          "SCTID:187777008",
          "UMLS:C0546835",
          "icd11.foundation:1938186540"
        ],
        "synonyms": [
          "cancer of intrahepatic bile duct",
          "malignant intrahepatic bile duct neoplasm",
          "malignant neoplasm of intrahepatic bile duct",
          "malignant neoplasm of intrahepatic bile ducts"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A cancer that involves the intrahepatic bile duct."
      },
      "child_count": 2,
      "reference_id": "MONDO:0001487"
    },
    {
      "id": 18978,
      "label": "cholangiocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18555
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4947",
          "EFO:0005221",
          "GARD:0009304",
          "ICDO:8160/3",
          "MEDGEN:60210",
          "MESH:D018281",
          "MedDRA:10004593",
          "MedDRA:10008593",
          "NCIT:C4436",
          "NORD:926",
          "ONCOTREE:CHOL",
          "Orphanet:70567",
          "SCTID:312104005",
          "UMLS:C0206698",
          "icd11.foundation:2110597275"
        ],
        "synonyms": [
          "bile duct cancer",
          "intrahepatic bile duct cancer (cholangiocarcinoma)",
          "CC",
          "CCA",
          "Cholangiocar.- intra/extrahepatic",
          "Cholangiocellular carcinoma",
          "cholangiocarcinoma",
          "cholangiocarcinoma, intrahepatic and extrahepatic bile ducts (adenocarcinoma)",
          "cholangiocarcinoma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the intrahepatic biliary tree (intrahepatic cholangiocarcinoma) or from the junction, or adjacent to the junction, of the right and left hepatic ducts (hilar cholangiocarcinoma). Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor."
      },
      "child_count": 1,
      "reference_id": "MONDO:0019087"
    }
  ],
  "children": [
    {
      "id": 5280,
      "label": "hilar cholangiocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5166
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4927",
          "DOID:5246",
          "EFO:1001959",
          "GARD:0010175",
          "MEDGEN:878855",
          "MESH:D018285",
          "NCIT:C36077",
          "Orphanet:99978",
          "SCTID:253017000",
          "UMLS:C4045991",
          "icd11.foundation:1571104786"
        ],
        "synonyms": [
          "Klatskin tumor",
          "Klatskin's tumor",
          "cholangiocarcinoma of hilar portion of hepatic duct",
          "hilar CC",
          "hilar CCA",
          "hilar cholangiocarcinoma",
          "hilar portion of hepatic duct cholangiocarcinoma",
          "hilar cholangiocellular carcinoma",
          "perihilar cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A cholangiocarcinoma that arises from the junction, or adjacent to the junction, of the right and left hepatic ducts."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003345"
    },
    {
      "id": 5914,
      "label": "mucinous intrahepatic cholangiocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4775,
        5166
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7024",
          "GARD:0023806",
          "MEDGEN:270842",
          "NCIT:C41618",
          "UMLS:C1513718"
        ],
        "synonyms": [
          "mucin-producing intrahepatic cholangiocarcinoma",
          "mucinous intrahepatic cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An intrahepatic cholangiocarcinoma that produces abundant mucin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004078"
    },
    {
      "id": 6131,
      "label": "cholangiolocellular carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5166,
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7642",
          "GARD:0023929",
          "MEDGEN:273143",
          "NCIT:C41617",
          "UMLS:C1516490"
        ],
        "synonyms": [
          "CLC",
          "cholangiocarcinoma of intralobular bile duct",
          "cholangiolocellular carcinoma",
          "intralobular bile duct cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An intrahepatic cholangiocarcinoma that arises from the canals of Hering."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004315"
    },
    {
      "id": 6161,
      "label": "signet ring cell intrahepatic cholangiocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4713,
        5166
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7733",
          "GARD:0023949",
          "MEDGEN:276815",
          "NCIT:C41619",
          "UMLS:C1519321"
        ],
        "synonyms": [
          "signet Ring cell intrahepatic cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An intrahepatic cholangiocarcinoma characterized by the presence of signet ring adenocarcinoma cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004346"
    },
    {
      "id": 6257,
      "label": "sarcomatous intrahepatic cholangiocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5166
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8072",
          "GARD:0024012",
          "MEDGEN:275403",
          "NCIT:C41620",
          "UMLS:C1519184"
        ],
        "synonyms": [
          "intrahepatic cholangiocarcinoma with extensive sarcomatous changes",
          "sarcomatoid intrahepatic cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, aggressive variant of intrahepatic cholangiocarcinoma. It is characterized by the presence of adenocarcinoma cells that are intermingled with malignant pleomorphic spindle cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004451"
    },
    {
      "id": 23442,
      "label": "perihilar intrahepatic cholangiocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5166
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025911",
          "NCIT:C96804",
          "ONCOTREE:PHCH"
        ],
        "synonyms": [
          "perihilar ICC",
          "perihilar bile duct carcinoma",
          "perihilar intrahepatic cholangiocarcinoma",
          "perihilar cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An intrahepatic cholangiocarcinoma that arises from the intrahepatic large bile ducts."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044788"
    }
  ],
  "roots": [
    {
      "id": 3698,
      "label": "intrahepatic bile duct cancer"
    },
    {
      "id": 18978,
      "label": "cholangiocarcinoma"
    }
  ]
}