{ "id": 5172, "label": "adenocarcinoma in situ", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0003218", "properties": { "xrefs": [ "DOID:4943", "ICDO:8140/2", "MEDGEN:87203", "MESH:D065311", "NCIT:C4123", "ONCOTREE:AIS", "UMLS:C0334276" ], "synonyms": [ "adenocarcinoma in situ", "AIS" ], "definition": "A lesion in which the normally situated glands are partially or completely replaced by atypical cells with malignant characteristics." }, "isLeaf": false, "isRoot": false, "child_count": 3, "parents": [ { "id": 6433, "label": "in situ carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6734, 20078, 20315 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8719", "ICD9:230-234", "ICD9:234.8", "ICD9:234.9", "ICDO:8010/2", "MEDGEN:763", "MESH:D002278", "NCIT:C2917", "SCTID:109355002", "UMLS:C0007099" ], "synonyms": [ "CIS", "carcinoma in situ", "carcinoma, in situ, malignant", "epithelial tumor, in situ, malignant", "intraepithelial carcinoma", "non-invasive carcinoma", "stage 0 disease" ], "definition": "A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion." }, "child_count": 63, "reference_id": "MONDO:0004647" }, { "id": 6712, "label": "adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6734, 21312 ], "type_id": 0, "properties": { "xrefs": [ "CSP:2000-0386", "DOID:299", "EFO:0000228", "ICDO:8140/3", "MEDGEN:122", "MESH:D000230", "NCIT:C2852", "ONCOTREE:ADNOS", "SCTID:443961001", "UMLS:C0001418" ], "synonyms": [ "adenocarcinoma", "adenocarcinoma NOS (morphologic abnormality)", "adenocarcinoma, malignant", "adenocarcinoma, no subtype (morphologic abnormality)", "adenocarcinomas", "ADNOS" ], "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma." }, "child_count": 128, "reference_id": "MONDO:0004970" } ], "children": [ { "id": 2959, "label": "lung adenocarcinoma in situ", "isLeaf": true, "isRoot": false, "parents": [ 5172, 6444, 6791 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050870", "GARD:0022780", "MEDGEN:1620128", "NCIT:C136486", "NCIT:C8748", "ONCOTREE:LAIS", "UMLS:C4521520" ], "synonyms": [ "lung adenocarcinoma In situ", "bronchioloalveolar carcinoma", "adenosquamous cell carcinoma in situ of lung", "adenosquamous cell carcinoma in situ of the lung", "bronchioalveolar carcinoma", "in situ pulmonary adenocarcinoma", "lung adenosquamous cell carcinoma in situ", "stage 0 adenosquamous cell carcinoma of lung", "stage 0 adenosquamous cell carcinoma of the lung", "stage 0 adenosquamous cell lung carcinoma", "stage 0 adenosquamous lung cancer", "stage 0 adenosquamous lung carcinoma aJCC v6", "stage 0 adenosquamous lung carcinoma aJCC v6 and v7", "stage 0 adenosquamous lung carcinoma aJCC v7" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A localized non-invasive adenocarcinoma of the lung measuring 3 cm or less. It is characterized by a pure lepidic growth pattern and the lack of stromal, vascular, or pleural invasion." }, "child_count": 0, "reference_id": "MONDO:0000503" }, { "id": 6758, "label": "ductal breast carcinoma in situ", "isLeaf": false, "isRoot": false, "parents": [ 5172, 5857, 6442, 7234 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0060074", "EFO:0000432", "ICDO:8500/2", "MEDGEN:765", "MESH:D002285", "NCIT:C2924", "ONCOTREE:DCIS", "UMLS:C0007124" ], "synonyms": [ "DCIS", "carcinoma in situ of mammary duct", "ductal breast carcinoma in situ", "ductal carcinoma in situ", "ductal carcinoma in situ (DCIS)", "ductal carcinoma in situ of breast", "ductal carcinoma in situ of the breast", "intraductal breast carcinoma", "intraductal carcinoma", "intraductal carcinoma of breast", "intraductal carcinoma of the breast", "mammary duct carcinoma in situ", "mammary duct in situ carcinoma", "non-infiltrating ductal adenocarcinoma of breast", "non-infiltrating ductal adenocarcinoma of the breast", "non-infiltrating ductal breast adenocarcinoma", "non-infiltrating ductal breast carcinoma", "non-infiltrating ductal carcinoma of breast", "non-infiltrating ductal carcinoma of the breast", "non-infiltrating intraductal adenocarcinoma", "non-infiltrating intraductal adenocarcinoma of breast", "non-infiltrating intraductal adenocarcinoma of the breast", "non-infiltrating intraductal breast adenocarcinoma", "non-infiltrating intraductal carcinoma", "non-invasive ductal adenocarcinoma of breast", "non-invasive ductal adenocarcinoma of the breast", "non-invasive ductal breast adenocarcinoma", "non-invasive ductal breast carcinoma", "non-invasive ductal carcinoma of breast", "non-invasive ductal carcinoma of the breast", "non-invasive intraductal adenocarcinoma of breast", "non-invasive intraductal adenocarcinoma of the breast", "non-invasive intraductal breast adenocarcinoma", "stage 0 mammary duct carcinoma", "breast ductal carcinoma in situ" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS." }, "child_count": 4, "reference_id": "MONDO:0005023" }, { "id": 7813, "label": "lobular breast carcinoma in situ", "isLeaf": true, "isRoot": false, "parents": [ 4565, 5172, 6729 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000326", "ICD10CM:D05.0", "ICDO:8520/2", "MEDGEN:79007", "NCIT:C4018", "ONCOTREE:LCIS", "SCTID:109888004", "UMLS:C0279563" ], "synonyms": [ "LCIS", "lobular Ca in situ of breast", "lobular Ca in situ of the breast", "lobular breast carcinoma in situ", "lobular carcinoma in situ", "lobular carcinoma in situ (LCIS)", "lobular carcinoma in situ of breast", "lobular carcinoma in situ of the breast", "lobular carcinoma in situ of the breast (LCIS)", "non-infiltrating lobular breast carcinoma", "non-infiltrating lobular carcinoma", "non-infiltrating lobular carcinoma of breast", "non-infiltrating lobular carcinoma of the breast", "non-invasive lobular breast carcinoma", "non-invasive lobular carcinoma of breast", "non-invasive lobular carcinoma of the breast", "breast lobular carcinoma in situ" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002657", "name": "breast disorder" } ], "definition": "A non-invasive adenocarcinoma of the breast characterized by a proliferation of monomorphic cells completely filling the lumina. The overall lobular architecture is preserved. It is frequently multifocal (90% in some series) and bilateral. It seldom becomes invasive; however there is an increased risk of infiltrating ductal adenocarcinoma." }, "child_count": 0, "reference_id": "MONDO:0006270" } ], "roots": [ { "id": 6433, "label": "in situ carcinoma" }, { "id": 6712, "label": "adenocarcinoma" } ] }