{
  "id": 5181,
  "label": "essential tremor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003233",
  "properties": {
    "xrefs": [
      "DOID:4990",
      "EFO:0003108",
      "ICD10CM:G25.0",
      "ICD9:333.1",
      "MEDGEN:78725",
      "MESH:D020329",
      "OMIMPS:190300",
      "Orphanet:862",
      "SCTID:609558009",
      "UMLS:C0270736"
    ],
    "synonyms": [
      "essential hereditary tremor",
      "tremor, hereditary essential"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A relatively common disorder characterized by a fairly specific pattern of tremors which are most prominent in the upper extremities and neck, inducing titubations of the head. The tremor is usually mild, but when severe may be disabling. An autosomal dominant pattern of inheritance may occur in some families (i.e., familial tremor). (Mov Disord 1988;13(1):5-10)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 7073,
      "label": "movement disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:480",
          "EFO:0004280",
          "ICD9:333.90",
          "ICD9:333.99",
          "MEDGEN:10113",
          "MESH:D009069",
          "NCIT:C116757",
          "SCTID:60342002",
          "UMLS:C0026650"
        ],
        "synonyms": [
          "movement disease",
          "movement disorder",
          "movement disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Neurological conditions resulting in abnormal voluntary or involuntary movement, which may impact the speed, fluency, quality and ease of movement."
      },
      "child_count": 54,
      "reference_id": "MONDO:0005395"
    },
    {
      "id": 24270,
      "label": "hereditary neurological disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6799
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "neurogenetic disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A heterogeneous group of genetic conditions with Mendelian (autosomal dominant, recessive, or X-linked) or chromosomal etiology characterized by abnormalities in the brain, spinal cord, nerves, or muscles."
      },
      "child_count": 528,
      "reference_id": "MONDO:0100545"
    }
  ],
  "children": [
    {
      "id": 9876,
      "label": "tremor, hereditary essential, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5181
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111428",
          "MEDGEN:349909",
          "MESH:C536545",
          "OMIM:190300",
          "UMLS:C1860861"
        ],
        "synonyms": [
          "DRD3 essential tremor",
          "essential tremor caused by mutation in DRD3",
          "essential tremor, hereditary, 1",
          "tremor, hereditary essential, 1",
          "tremor, hereditary essential, type 1",
          "ETM1",
          "FET1",
          "tremor familial essential, 1",
          "tremor hereditary essential, 1",
          "tremor, familial essential, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any essential tremor in which the cause of the disease is a mutation in the DRD3 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008590"
    },
    {
      "id": 12323,
      "label": "tremor, hereditary essential, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5181
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111429",
          "MEDGEN:356087",
          "MESH:C536546",
          "OMIM:602134",
          "UMLS:C1865810"
        ],
        "synonyms": [
          "ETM2",
          "essential tremor, hereditary, 2",
          "tremor, hereditary essential, 2",
          "tremor hereditary essential, 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011201"
    },
    {
      "id": 13711,
      "label": "tremor, hereditary essential, 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5181
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111430",
          "MEDGEN:409870",
          "MESH:C566949",
          "OMIM:611456",
          "UMLS:C1969617"
        ],
        "synonyms": [
          "ETM3",
          "essential tremor, hereditary, 3",
          "tremor, hereditary essential, 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012671"
    },
    {
      "id": 14900,
      "label": "tremor, hereditary essential, 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5181
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111431",
          "MEDGEN:761337",
          "OMIM:614782",
          "UMLS:C3539195"
        ],
        "synonyms": [
          "FUS essential tremor",
          "essential tremor caused by mutation in FUS",
          "essential tremor, hereditary, 4",
          "tremor, hereditary essential, 4",
          "tremor, hereditary essential, type 4",
          "ETM4"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any essential tremor in which the cause of the disease is a mutation in the FUS gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013888"
    },
    {
      "id": 15747,
      "label": "tremor, hereditary essential, 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5181
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111432",
          "MEDGEN:897748",
          "OMIM:616736",
          "UMLS:C4225223"
        ],
        "synonyms": [
          "ETM5",
          "TENM4 essential tremor",
          "essential tremor caused by mutation in TENM4",
          "essential tremor, hereditary, 5",
          "tremor, hereditary essential, 5",
          "tremor, hereditary essential, 5; ETM5",
          "tremor, hereditary essential, type 5"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any essential tremor in which the cause of the disease is a mutation in the TENM4 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014756"
    },
    {
      "id": 21810,
      "label": "tremor, hereditary essential, 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5181
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081295",
          "MEDGEN:1711112",
          "OMIM:618866",
          "UMLS:C5394329"
        ],
        "synonyms": [
          "ETM6",
          "TREMOR, HEREDITARY ESSENTIAL, 6",
          "tremor, hereditary essential, 6"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0030027"
    }
  ],
  "roots": [
    {
      "id": 7073,
      "label": "movement disorder"
    },
    {
      "id": 24270,
      "label": "hereditary neurological disease"
    }
  ]
}