{
  "id": 5187,
  "label": "thyroid gland disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003240",
  "properties": {
    "xrefs": [
      "DOID:50",
      "EFO:1000627",
      "ICD10CM:E00-E07",
      "ICD9:240-246",
      "ICD9:246.8",
      "ICD9:246.9",
      "MEDGEN:1378579",
      "MESH:D013959",
      "NCIT:C26893",
      "SCTID:14304000",
      "UMLS:C4317107",
      "Wikipedia:Thyroid_disease"
    ],
    "synonyms": [
      "disease of thyroid gland",
      "disease or disorder of thyroid gland",
      "disorder of thyroid gland",
      "thyroid disease",
      "thyroid gland disease",
      "thyroid gland disease or disorder",
      "thyroid gland diseases",
      "thyroid gland disorder",
      "thyroid gland disorders"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A disease involving the thyroid gland."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 6875,
      "label": "endocrine system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:28",
          "EFO:0001379",
          "ICD9:259.8",
          "ICD9:259.9",
          "MEDGEN:4043",
          "MESH:D004700",
          "NANDO:1100009",
          "NANDO:2100109",
          "NCIT:C3009",
          "SCTID:362969004",
          "UMLS:C0014130"
        ],
        "synonyms": [
          "disease of endocrine system",
          "disease or disorder of endocrine system",
          "disorder of endocrine system",
          "endocrine disease",
          "endocrine disorder",
          "endocrine system disease",
          "endocrine system disease or disorder",
          "endocrine system disorder",
          "endocrinopathy",
          "thyroid or other glandular disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the endocrine system."
      },
      "child_count": 48,
      "reference_id": "MONDO:0005151"
    }
  ],
  "children": [
    {
      "id": 3732,
      "label": "thyrocalcitonin secretion disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12424",
          "ICD9:246.0",
          "MEDGEN:675237",
          "SCTID:190303007",
          "UMLS:C0701822"
        ],
        "synonyms": [
          "disorder of thyrocalcitonin secretion"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001525"
    },
    {
      "id": 5955,
      "label": "thyroiditis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7166",
          "HP:0100646",
          "ICD10CM:E06",
          "ICD10WHO:E06",
          "ICD9:245",
          "ICD9:245.9",
          "MEDGEN:21548",
          "MESH:D013966",
          "NCIT:C26894",
          "SCTID:82119001",
          "UMLS:C0040147",
          "icd11.foundation:587793334"
        ],
        "synonyms": [
          "inflammation of thyroid gland",
          "thyroid gland inflammation",
          "thyroiditis",
          "thyroiditis (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Inflammation of the thyroid gland. This category includes Hashimoto thyroiditis, Riedel thyroiditis, acute thyroiditis, subacute thyroiditis, and radiation-induced thyroiditis."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004126"
    },
    {
      "id": 6233,
      "label": "hyperthyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7998",
          "EFO:0009189",
          "ICD9:242.90",
          "MEDGEN:6972",
          "MESH:D006980",
          "NANDO:2100119",
          "NANDO:2200329",
          "NCIT:C3123",
          "SCTID:34486009",
          "UMLS:C0020550"
        ],
        "synonyms": [
          "overactive thyroid"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004425"
    },
    {
      "id": 6362,
      "label": "thyroid malformation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8433",
          "MEDGEN:209098",
          "NCIT:C27331",
          "UMLS:C0877367"
        ],
        "synonyms": [
          "thyroid gland malformation"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An anatomic abnormality of the thyroid gland."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004564"
    },
    {
      "id": 7020,
      "label": "hyperthyroxinemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2855",
          "EFO:0004127",
          "HGNC:399",
          "MEDGEN:6973",
          "MESH:D006981",
          "UMLS:C0020551"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Abnormally elevated thyroxine level in the blood."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005333"
    },
    {
      "id": 7075,
      "label": "goiter",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12176",
          "EFO:0004283",
          "HP:0000853",
          "ICD9:240.9",
          "MEDGEN:42270",
          "MESH:D006042",
          "NCIT:C26785",
          "SCTID:3716002",
          "UMLS:C0018021"
        ],
        "synonyms": [
          "Thyromegaly",
          "goiter",
          "goiter (disease)",
          "goitre (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005397"
    },
    {
      "id": 7093,
      "label": "hypothyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1459",
          "EFO:0004705",
          "ICD9:244.9",
          "MEDGEN:6991",
          "MESH:D007037",
          "NANDO:2100120",
          "NCIT:C26800",
          "SCTID:40930008",
          "UMLS:C0020676",
          "icd11.foundation:1722092627"
        ],
        "synonyms": [
          "hypothyroidism",
          "underactive thyroid",
          "hypothyroid"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Abnormally low levels of thyroid hormone."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005420"
    },
    {
      "id": 7688,
      "label": "C-cell hyperplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5187,
        6775
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000147",
          "MEDGEN:90975",
          "NCIT:C46100",
          "UMLS:C0342190"
        ],
        "synonyms": [
          "C-cell hyperplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Neoplastic or reactive proliferation of the C-cells in the thyroid gland. The neoplastic C-cell hyperplasia is associated with familial medullary thyroid gland carcinoma and multiple endocrine neoplasia type II and IIB. Morphologically, it is characterized by the presence of clusters of intrafollicular C-cells with atypical cytologic features. The reactive C-cell hyperplasia is also known as physiological or secondary C-cell hyperplasia and it is associated with conditions that cause hypercalcemia (e.g., hyperparathyroidism)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006120"
    },
    {
      "id": 8136,
      "label": "atrophy of thyroid",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000827",
          "ICD9:246.8",
          "MEDGEN:453383",
          "MedDRA:10043693",
          "NCIT:C26942",
          "SCTID:190309006",
          "UMLS:C2981141",
          "icd11.foundation:1827568994"
        ],
        "synonyms": [
          "thyroid atrophy",
          "thyroid gland atrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Tissue degeneration and diminished size of the thyroid gland."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006666"
    },
    {
      "id": 8210,
      "label": "euthyroid sick syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2856",
          "EFO:1000931",
          "ICD10CM:E07.81",
          "ICD9:790.94",
          "MEDGEN:41908",
          "MESH:D005067",
          "MedDRA:10015549",
          "NCIT:C113170",
          "SCTID:237542005",
          "UMLS:C0015190"
        ],
        "synonyms": [
          "euthyroid sick syndrome",
          "sick euthyroid syndrome",
          "sick-euthyroid syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Abnormal thyroid function tests, low triiodothyronine with elevated reverse triiodothyronine, in the setting of non-thyroidal illness."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006755"
    },
    {
      "id": 16048,
      "label": "thyroid tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003841",
          "GARD:0019762",
          "ICD9:239.7",
          "MEDGEN:21546",
          "NCIT:C3414",
          "ONCOTREE:THYROID",
          "Orphanet:100087",
          "SCTID:127018007",
          "UMLS:C0040136"
        ],
        "synonyms": [
          "neoplasm of the thyroid",
          "neoplasm of the thyroid gland",
          "neoplasm of thyroid",
          "neoplasm of thyroid gland",
          "thyroid gland neoplasm",
          "thyroid gland neoplasm (disease)",
          "thyroid gland tumor",
          "thyroid gland tumour",
          "thyroid neoplasm",
          "thyroid neoplasms",
          "thyroid tumor",
          "tumor of the thyroid",
          "tumor of the thyroid gland",
          "tumor of thyroid",
          "tumor of thyroid gland",
          "tumour of the thyroid",
          "tumour of the thyroid gland",
          "tumour of thyroid",
          "tumour of thyroid gland",
          "THYROID"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the thyroid gland."
      },
      "child_count": 10,
      "reference_id": "MONDO:0015074"
    },
    {
      "id": 23532,
      "label": "inherited thyroid metabolism disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187,
        18954
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025937",
          "ICD9:246.8",
          "MEDGEN:543589",
          "SCTID:36985004",
          "UMLS:C0271824"
        ],
        "synonyms": [
          "inborn error of thyroid hormone metabolic process",
          "inborn thyroid hormone metabolic process disorder",
          "inherited disorder of thyroid metabolism",
          "rare inborn error of thyroid hormone metabolic process"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An inherited metabolic disease that is has its basis in the disruption of thyroid hormone metabolic process."
      },
      "child_count": 4,
      "reference_id": "MONDO:0045046"
    }
  ],
  "roots": [
    {
      "id": 6875,
      "label": "endocrine system disorder"
    }
  ]
}