{
  "id": 5189,
  "label": "hepatocellular clear cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003243",
  "properties": {
    "xrefs": [
      "DOID:5016",
      "GARD:0023418",
      "ICDO:8174/3",
      "MEDGEN:690059",
      "NCIT:C5754",
      "UMLS:C1266020"
    ],
    "synonyms": [
      "clear cell carcinoma of liver cells",
      "clear cell carcinoma of the liver cells",
      "clear cell hepatocellular cancer",
      "clear cell hepatocellular carcinoma",
      "hepatocellular clear cell carcinoma",
      "liver cell clear cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A morphologic variant of hepatocellular carcinoma characterized by the presence of clear cells."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6742,
      "label": "clear cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4468",
          "EFO:0000348",
          "ICDO:8310/3",
          "MEDGEN:64629",
          "MESH:D018262",
          "NCIT:C3766",
          "UMLS:C0206681"
        ],
        "synonyms": [
          "adenocarcinoma, clear cell, malignant",
          "clear cell adenocarcinoma",
          "clear cell adenocarcinoma (morphologic abnormality)",
          "clear cell adenocarcinoma NOS (morphologic abnormality)",
          "mesonephroma NOS (morphologic abnormality)",
          "water-clear cell adenocarcinoma (morphologic abnormality)",
          "Wolffian duct neoplasm",
          "clear cell carcinoma",
          "malignant mesonephroma",
          "mesonephroid clear cell adenocarcinoma",
          "mesonephroid clear cell carcinoma",
          "mesonephroma, malignant",
          "mesonephroma, malignant (morphologic abnormality)",
          "water-clear cell carcinoma"
        ],
        "definition": "A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid."
      },
      "child_count": 11,
      "reference_id": "MONDO:0005004"
    },
    {
      "id": 8660,
      "label": "hepatocellular carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:684",
          "DOID:686",
          "EFO:0000182",
          "GARD:0016773",
          "ICD10CM:C22.0",
          "ICDO:8170/3",
          "MEDGEN:389187",
          "MESH:D006528",
          "MedDRA:10049010",
          "NANDO:2200047",
          "NCIT:C3099",
          "NORD:1907",
          "OMIM:114550",
          "ONCOTREE:HCC",
          "Orphanet:88673",
          "UMLS:C2239176",
          "icd11.foundation:1294035808"
        ],
        "synonyms": [
          "HCC",
          "cancer, hepatocellular",
          "carcinoma of liver",
          "carcinoma of liver cells",
          "carcinoma of the liver cells",
          "carcinoma, hepatocellular, malignant",
          "hepatoblastoma, somatic",
          "hepatocellular adenocarcinoma",
          "hepatocellular cancer",
          "hepatocellular cancer, somatic",
          "hepatocellular carcinoma",
          "hepatocellular carcinoma, childhood type, somatic",
          "hepatocellular carcinoma, somatic",
          "hepatoma",
          "liver carcinoma",
          "liver cell cancer (hepatocellular carcinoma)",
          "liver cell carcinoma",
          "primary carcinoma of liver cells",
          "primary carcinoma of the liver cells",
          "adult hepatoma",
          "adult primary hepatocellular carcinoma",
          "hepatoblastoma",
          "hepatoblastoma caused by somatic mutation",
          "liver and intrahepatic bile duct carcinoma",
          "liver cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation."
      },
      "child_count": 16,
      "reference_id": "MONDO:0007256"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6742,
      "label": "clear cell adenocarcinoma"
    },
    {
      "id": 8660,
      "label": "hepatocellular carcinoma"
    }
  ]
}