{
  "id": 5194,
  "label": "pineal gland cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003249",
  "properties": {
    "xrefs": [
      "DOID:5032",
      "GARD:0027637",
      "ICD10CM:C75.3",
      "ICD9:194.4",
      "MEDGEN:102284",
      "NCIT:C3573",
      "SCTID:363483004",
      "UMLS:C0153655"
    ],
    "synonyms": [
      "neoplasm of the pineal region",
      "pineocytic tumor",
      "pineocytic tumour",
      "tumor of the pineal region",
      "tumour of the pineal region",
      "cancer of pineal body",
      "malignant neoplasm of pineal body",
      "malignant neoplasm of pineal gland",
      "malignant neoplasm of the pineal gland",
      "malignant pineal area neoplasm",
      "malignant pineal area tumor",
      "malignant pineal area tumour",
      "malignant pineal body neoplasm",
      "malignant pineal gland neoplasm",
      "malignant pineal gland tumor",
      "malignant pineal gland tumour",
      "malignant pineal region neoplasm",
      "malignant pineal region tumor",
      "malignant pineal region tumour",
      "malignant tumor of pineal gland",
      "malignant tumor of the pineal gland",
      "malignant tumour of pineal gland",
      "malignant tumour of the pineal gland",
      "pineal body cancer",
      "pinealoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Abnormal malignant growth of the cells that comprise the pineal parenchyma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5646,
      "label": "thalamic cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4814,
        5067
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6098",
          "GARD:0027647",
          "MEDGEN:83429",
          "NCIT:C4576",
          "SCTID:188287005",
          "UMLS:C0346902",
          "icd11.foundation:610018988"
        ],
        "synonyms": [
          "cancer of dorsal plus ventral thalamus",
          "dorsal plus ventral thalamus cancer",
          "malignant dorsal plus ventral thalamus neoplasm",
          "malignant neoplasm of dorsal plus ventral thalamus",
          "malignant neoplasm of thalamus",
          "malignant neoplasm of the thalamus",
          "malignant thalamic neoplasm",
          "malignant thalamic neoplasms",
          "malignant thalamic tumor",
          "malignant thalamic tumors",
          "malignant thalamic tumour",
          "malignant thalamic tumours",
          "malignant thalamus neoplasm",
          "malignant thalamus neoplasms",
          "malignant thalamus tumor",
          "malignant thalamus tumors",
          "malignant thalamus tumour",
          "malignant thalamus tumours",
          "malignant tumor of thalamus",
          "malignant tumor of the thalamus",
          "malignant tumour of thalamus",
          "malignant tumour of the thalamus",
          "tumour of thalamus",
          "thalamic neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A cancer involving a dorsal plus ventral thalamus."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003766"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:170",
          "ICD9:194.9",
          "MEDGEN:56319",
          "MESH:D004701",
          "NCIT:C3575",
          "UMLS:C0153658"
        ],
        "synonyms": [
          "endocrine neoplasm",
          "Endocrine tumour",
          "cancer of endocrine gland",
          "endocrine cancer",
          "endocrine gland cancer",
          "endocrine neoplasm, malignant",
          "malignant endocrine gland neoplasm",
          "malignant endocrine gland tumor",
          "malignant endocrine gland tumour",
          "malignant endocrine neoplasm",
          "malignant endocrine tumor",
          "malignant endocrine tumour",
          "malignant neoplasm of endocrine gland",
          "malignant neoplasm of the endocrine gland",
          "malignant tumor of endocrine gland",
          "malignant tumor of the endocrine gland",
          "malignant tumour of the endocrine gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0021069"
    },
    {
      "id": 20442,
      "label": "pineal body neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        5067,
        20429,
        23822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:237252",
          "NCIT:C3328",
          "ONCOTREE:PINT",
          "UMLS:C1412004"
        ],
        "synonyms": [
          "neoplasm of pineal area",
          "neoplasm of pineal body",
          "neoplasm of pineal region",
          "neoplasm of the pineal area",
          "neoplasm of the pineal region",
          "pineal area neoplasm",
          "pineal area tumor",
          "pineal area tumour",
          "pineal body neoplasm (disease)",
          "pineal body tumor",
          "pineal body tumour",
          "pineal neoplasm",
          "pineal region neoplasm",
          "pineal region tumor",
          "pineal region tumour",
          "pineal tumor",
          "pineal tumour",
          "pinealoma",
          "tumor of pineal area",
          "tumor of pineal body",
          "tumor of pineal region",
          "tumor of the pineal area",
          "tumor of the pineal region",
          "tumour of pineal area",
          "tumour of pineal body",
          "tumour of pineal region",
          "tumour of the pineal area",
          "tumour of the pineal region"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the pineal body."
      },
      "child_count": 20,
      "reference_id": "MONDO:0021232"
    }
  ],
  "children": [
    {
      "id": 4216,
      "label": "malignant pineal area germ cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4999,
        5094,
        5194
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1660",
          "GARD:0012017",
          "ICD9:239.7",
          "MEDGEN:233159",
          "NCIT:C6767",
          "SCTID:277508009",
          "UMLS:C1334612"
        ],
        "synonyms": [
          "malignant germ cell neoplasm of pineal gland",
          "malignant germ cell neoplasm of pineal parenchyma",
          "malignant germ cell neoplasm of the pineal gland",
          "malignant germ cell neoplasm of the pineal parenchyma",
          "malignant germ cell tumor of pineal gland",
          "malignant germ cell tumor of pineal parenchyma",
          "malignant germ cell tumor of the pineal gland",
          "malignant germ cell tumor of the pineal parenchyma",
          "malignant germ cell tumour of pineal gland",
          "malignant germ cell tumour of pineal parenchyma",
          "malignant germ cell tumour of the pineal gland",
          "malignant germ cell tumour of the pineal parenchyma",
          "malignant pineal area germ cell tumor",
          "malignant pineal area germ cell tumour",
          "malignant pineal gland germ cell neoplasm",
          "malignant pineal gland germ cell tumor",
          "malignant pineal gland germ cell tumour",
          "malignant pineal parenchymal germ cell neoplasm",
          "malignant pineal parenchymal germ cell tumor",
          "malignant pineal parenchymal germ cell tumour",
          "malignant pineal region germ cell neoplasm",
          "malignant pineal region germ cell tumor",
          "malignant pineal region germ cell tumour",
          "pineal germ cell neoplasm, malignant",
          "pineal germ cell tumour",
          "pineal region germ cell tumour",
          "pineal cell tumor",
          "pineal cell tumour",
          "pineal region germinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor that arises in the pineal region. Representative examples include germinoma, immature teratoma, choriocarcinoma, embryonal carcinoma and yolk sac tumor."
      },
      "child_count": 15,
      "reference_id": "MONDO:0002073"
    },
    {
      "id": 5135,
      "label": "pineal gland astrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5133,
        5194
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4858",
          "GARD:0023395",
          "MEDGEN:83711",
          "NCIT:C8274",
          "UMLS:C0280795"
        ],
        "synonyms": [
          "astrocytoma (excluding glioblastoma) of pineal body",
          "astrocytoma of pineal gland",
          "astrocytoma of the pineal gland",
          "pineal astrocytic tumour",
          "pineal astrocytoma",
          "pineal body astrocytoma",
          "pineal body astrocytoma (excluding glioblastoma)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A astrocytoma that involves the pineal body."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003171"
    },
    {
      "id": 17178,
      "label": "pineoblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5194,
        7212
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1664",
          "EFO:1000475",
          "GARD:0009369",
          "ICDO:9362/3",
          "MEDGEN:104745",
          "MedDRA:10050487",
          "NCIT:C9344",
          "ONCOTREE:PBL",
          "Orphanet:251909",
          "UMLS:C0205898"
        ],
        "synonyms": [
          "PNET of pineal gland",
          "PNET of the pineal gland",
          "pineal PNET",
          "pineal gland PNET",
          "pineal gland primitive neuroectodermal neoplasm",
          "pineal gland primitive neuroectodermal tumor",
          "pineal gland primitive neuroectodermal tumour",
          "pineal primitive neuroectodermal neoplasm",
          "pineal primitive neuroectodermal tumor",
          "pineal primitive neuroectodermal tumour",
          "pineoblastoma",
          "pineoblastoma (WHO grade IV)",
          "pineoblastoma, malignant",
          "primitive neuroectodermal neoplasm of pineal gland",
          "primitive neuroectodermal neoplasm of the pineal gland",
          "primitive neuroectodermal tumor of pineal gland",
          "primitive neuroectodermal tumor of the pineal gland",
          "primitive neuroectodermal tumour of pineal gland",
          "primitive neuroectodermal tumour of the pineal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pineoblastoma is a rare, malignant type of supratentorial primitive neuroectodermal tumor (sPNET), found mainly in children (less than 10% of cases are reported in adults), and located in the pineal region of the brain but that can metastasize along the neuroaxis. As it is the most aggressive of the pineal parenchymal tumors, it is usually associated with a poor prognosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016722"
    }
  ],
  "roots": [
    {
      "id": 5646,
      "label": "thalamic cancer"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm"
    },
    {
      "id": 20442,
      "label": "pineal body neoplasm"
    }
  ]
}