{
  "id": 5197,
  "label": "granular cell cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003252",
  "properties": {
    "xrefs": [
      "DOID:5042",
      "GARD:0023423",
      "ICD9:171.9",
      "ICDO:9580/3",
      "MEDGEN:87276",
      "NCIT:C4336",
      "SCTID:404041003",
      "UMLS:C0334618"
    ],
    "synonyms": [
      "granular cell tumor, malignant",
      "granular cell tumor, malignant (morphologic abnormality)",
      "malignant granular cell myoblastoma",
      "malignant granular cell neoplasm",
      "malignant granular cell tumor",
      "malignant granular cell tumour",
      "myoblastoma, malignant"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An uncommon granular cell tumor which may metastasize to other anatomic sites. Morphologic characteristics include the presence of spindling neoplastic cells, necrosis, extensive pleomorphism, prominent nucleoli, and increased mitiotic activity."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7788,
      "label": "granular cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2411",
          "EFO:1000284",
          "GARD:0009618",
          "ICD9:215.9",
          "ICDO:9580/0",
          "MEDGEN:88345",
          "MESH:C535558",
          "MESH:D016586",
          "NCIT:C3474",
          "ONCOTREE:GCT",
          "SCTID:404035005",
          "UMLS:C0085167"
        ],
        "synonyms": [
          "Abrikossoff tumor",
          "Abrikossoff tumour",
          "Abrikossoff's tumor",
          "Abrikossoff's tumour",
          "granular cell myoblastoma",
          "granular cell neoplasm",
          "granular cell nerve sheath tumor",
          "granular cell nerve sheath tumour",
          "granular cell schwannoma",
          "granular cell tumor",
          "granular cell tumor (morphologic abnormality)",
          "granular cell tumour (morphologic abnormality)",
          "granular cell tumor NOS (morphologic abnormality)",
          "granular cell tumour NOS (morphologic abnormality)",
          "neoplasm of granular cell",
          "Abrikosoff's granulous cell tumor",
          "Abrikosoff's granulous cell tumour",
          "Abrikosoff's tumor",
          "Abrikosoff's tumour",
          "Abrikosov's tumor",
          "Abrikosov's tumour",
          "Abrikosov’s tumor",
          "Abrikosov’s tumour",
          "GCT",
          "giant granulocellular Abrikosov's tumor",
          "giant granulocellular Abrikosov's tumour",
          "malignant variant of Abrikosov's tumor",
          "malignant variant of Abrikosov's tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006235"
    },
    {
      "id": 20329,
      "label": "peripheral nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3627,
        7479
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:171.9",
          "MEDGEN:155556",
          "NCIT:C4961",
          "SCTID:254986007",
          "UMLS:C0751428"
        ],
        "synonyms": [
          "cancer of peripheral nervous system",
          "malignant PNS neoplasm",
          "malignant PNS tumor",
          "malignant PNS tumour",
          "malignant neoplasm of PNS",
          "malignant neoplasm of peripheral nerve",
          "malignant neoplasm of peripheral nervous system",
          "malignant neoplasm of the PNS",
          "malignant neoplasm of the peripheral nerve",
          "malignant neoplasm of the peripheral nervous system",
          "malignant neoplasms, peripheral nerve",
          "malignant peripheral nerve neoplasm",
          "malignant peripheral nerve tumor",
          "malignant peripheral nerve tumour",
          "malignant peripheral nervous system neoplasm",
          "malignant peripheral nervous system tumor",
          "malignant peripheral nervous system tumour",
          "malignant tumor of PNS",
          "malignant tumor of peripheral nerve",
          "malignant tumor of peripheral nervous system",
          "malignant tumor of the PNS",
          "malignant tumor of the peripheral nerve",
          "malignant tumor of the peripheral nervous system",
          "malignant tumour of PNS",
          "malignant tumour of peripheral nerve",
          "malignant tumour of peripheral nervous system",
          "malignant tumour of the PNS",
          "malignant tumour of the peripheral nerve",
          "malignant tumour of the peripheral nervous system",
          "peripheral nervous system cancer",
          "peripheral nervous system neoplasms, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Malignant growth of cells in the peripheral nervous system (PNS)or Autonomic Nervous System (ANS), without specification as to location"
      },
      "child_count": 36,
      "reference_id": "MONDO:0021089"
    },
    {
      "id": 24071,
      "label": "malignant glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20078,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3070",
          "GARD:0026148",
          "ICDO:9380/3",
          "MEDGEN:107826",
          "MedDRA:10018338",
          "NCIT:C4822",
          "UMLS:C0555198"
        ],
        "synonyms": [
          "glioma",
          "neuroglial tumor",
          "neuroglial tumour",
          "glial cell tumour",
          "glioma, malignant",
          "high grade glioma",
          "high-grade glioma",
          "malignant glial neoplasm",
          "malignant glial tumor",
          "malignant glial tumour",
          "malignant glioma",
          "malignant neuroglial neoplasm",
          "malignant neuroglial tumor",
          "malignant neuroglial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0100342"
    }
  ],
  "children": [
    {
      "id": 3313,
      "label": "malignant gastric granular cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3312,
        5197
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10536",
          "GARD:0022870",
          "MEDGEN:233664",
          "NCIT:C5484",
          "UMLS:C1334585"
        ],
        "synonyms": [
          "malignant gastric granular cell neoplasm",
          "malignant gastric granular cell tumor",
          "malignant granular cell neoplasm of stomach",
          "malignant granular cell neoplasm of the stomach",
          "malignant granular cell stomach neoplasm",
          "malignant granular cell stomach tumor",
          "malignant granular cell stomach tumour",
          "malignant granular cell tumor of stomach",
          "malignant granular cell tumor of the stomach",
          "malignant granular cell tumour of the stomach"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A metastasizing granular cell tumor that arises from the stomach."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001057"
    },
    {
      "id": 5156,
      "label": "granular cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5197,
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4903",
          "GARD:0023408",
          "ICDO:8320/3",
          "MEDGEN:104695",
          "NCIT:C3681",
          "UMLS:C0205644"
        ],
        "synonyms": [
          "granular cell adenocarcinoma",
          "granular cell carcinoma",
          "granular cell carcinoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An adenocarcinoma characterized by the presence of malignant epithelial cells with granular cytoplasm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003197"
    },
    {
      "id": 5285,
      "label": "granular cell leiomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5197,
        5284
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5258",
          "GARD:0023466",
          "MEDGEN:234321",
          "NCIT:C27494",
          "UMLS:C1333871"
        ],
        "synonyms": [
          "granular cell leiomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An aggressive malignant smooth muscle neoplasm. It is characterized by the presence of malignant smooth muscle cells with granular cytoplasmic changes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003350"
    },
    {
      "id": 6130,
      "label": "malignant cutaneous granular cell skin tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4403,
        5197,
        5298
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7639",
          "GARD:0023928",
          "MEDGEN:233658",
          "NCIT:C5614",
          "UMLS:C1334575"
        ],
        "synonyms": [
          "malignant cutaneous granular cell tumor",
          "malignant cutaneous granular cell tumour",
          "malignant granular cell neoplasm of skin",
          "malignant granular cell neoplasm of the skin",
          "malignant granular cell skin neoplasm",
          "malignant granular cell skin tumor",
          "malignant granular cell tumor of skin",
          "malignant granular cell tumor of the skin",
          "malignant granular cell tumour of the skin"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004314"
    }
  ],
  "roots": [
    {
      "id": 7788,
      "label": "granular cell tumor"
    },
    {
      "id": 20329,
      "label": "peripheral nervous system cancer"
    },
    {
      "id": 24071,
      "label": "malignant glioma"
    }
  ]
}