{
  "id": 5210,
  "label": "ependymal tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003266",
  "properties": {
    "xrefs": [
      "EFO:1000027",
      "GARD:0016527",
      "MEDGEN:232459",
      "NCIT:C6770",
      "ONCOTREE:EPMT",
      "Orphanet:301",
      "UMLS:C1333407"
    ],
    "synonyms": [
      "ependymal neoplasm",
      "ependymal tumor",
      "ependymal tumors",
      "ependymal tumours",
      "ependymomal tumor",
      "ependymomal tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A group of neoplasms which arise from the ependymal lining of the cerebral ventricles and from the remnants of the central canal of the spinal cord. Ependymal tumors occur predominantly in children and young adults with varied morphological features and biological behavior. There are 4 types: ependymoma, anaplastic ependymoma, myxopapillary ependymoma and subependymoma. (WHO)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 20287,
      "label": "glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20418
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005543",
          "GARD:0006513",
          "MEDGEN:9030",
          "MESH:D005910",
          "NCIT:C3059",
          "Orphanet:182067",
          "SCTID:393564001",
          "UMLS:C0017638"
        ],
        "synonyms": [
          "glial neoplasm",
          "glial tumor",
          "glial tumour",
          "glioma",
          "neoplasm of neuroglia",
          "neoplasm of the neuroglia",
          "neuroglial neoplasm",
          "neuroglial tumor",
          "neuroglial tumour",
          "tumor of neuroglia",
          "tumor of the neuroglia",
          "tumour of neuroglia",
          "tumour of the neuroglia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas."
      },
      "child_count": 9,
      "reference_id": "MONDO:0021042"
    }
  ],
  "children": [
    {
      "id": 6066,
      "label": "ependymal tumor of brain",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5210,
        7155
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7497",
          "GARD:0023897",
          "MEDGEN:116038",
          "NCIT:C3861",
          "SCTID:254939008",
          "UMLS:C0238029"
        ],
        "synonyms": [
          "brain ependymal tumor",
          "brain ependymal tumour",
          "ependymal tumor of brain",
          "brain ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A tumor arising from the ependymal lining of the ventricles."
      },
      "child_count": 12,
      "reference_id": "MONDO:0004245"
    },
    {
      "id": 17161,
      "label": "ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5210,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4844",
          "EFO:1000028",
          "GARD:0006353",
          "ICDO:9391/3",
          "MEDGEN:41825",
          "MESH:D004806",
          "MedDRA:10014967",
          "NANDO:2200088",
          "NCIT:C3017",
          "ONCOTREE:EPM",
          "Orphanet:251636",
          "UMLS:C0014474"
        ],
        "synonyms": [
          "benign ependymoma",
          "ependymoma",
          "WHO grade II ependymal neoplasm",
          "WHO grade II ependymal tumor",
          "WHO grade II ependymal tumour",
          "ependymoma, benign",
          "clear cell ependymoma (histologic variant)",
          "ependymoma, familial",
          "papillary ependymoma (histologic variant)",
          "tanycytic ependymoma (histologic variant)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade II, slow growing tumor of children and young adults, usually located intraventricularly. It is the most common ependymal neoplasm. It often causes clinical symptoms by blocking cerebrospinal fluid pathways. Key histological features include perivascular pseudorosettes and ependymal rosettes. (WHO)"
      },
      "child_count": 16,
      "reference_id": "MONDO:0016698"
    },
    {
      "id": 17162,
      "label": "myxopapillary ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5210
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5075",
          "GARD:0010633",
          "ICDO:9394/1",
          "MEDGEN:104717",
          "NCIT:C3697",
          "ONCOTREE:MPE",
          "Orphanet:251643",
          "UMLS:C0205769"
        ],
        "synonyms": [
          "ependymoma, benign",
          "myxopapillary ependymoma",
          "myxopapillary ependymoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Myxopapillary ependymoma (MEPN) describes a slow growing ependymoma located almost exclusively in the conus medullaris-cauda equina-filum terminale region of the spinal cord, presenting in all age groups, and manifesting with variable symptoms such as neck pain, vomiting and unsteady gait and metastasis. It has a more aggressive disease course and is seen in the pediatric population."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016699"
    },
    {
      "id": 17163,
      "label": "anaplastic ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5210,
        20048,
        20696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5074",
          "DOID:5889",
          "GARD:0010634",
          "ICDO:9392/3",
          "MEDGEN:128891",
          "MedDRA:10014968",
          "NCIT:C4049",
          "ONCOTREE:APE",
          "Orphanet:251646",
          "UMLS:C0280788"
        ],
        "synonyms": [
          "ependymal tumors",
          "ependymal tumours",
          "WHO grade III ependymal neoplasm",
          "WHO grade III ependymal tumor",
          "WHO grade III ependymal tumour",
          "anaplastic ependymal neoplasm",
          "anaplastic ependymal tumor",
          "anaplastic ependymal tumour",
          "anaplastic ependymoma",
          "ependymoma, anaplastic, malignant",
          "ependymoma, malignant",
          "high-grade ependymoma",
          "malignant ependymoma",
          "undifferentiated ependymal neoplasm",
          "undifferentiated ependymal tumor",
          "undifferentiated ependymal tumour",
          "undifferentiated ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anaplastic ependymoma is a rare, malignant type of ependymoma that most often arises in the supratentorial region of the brain of children and young adults and that manifests with variable symptoms including headaches, nausea, vision impairment, memory loss and difficulty walking."
      },
      "child_count": 9,
      "reference_id": "MONDO:0016700"
    },
    {
      "id": 20661,
      "label": "ependymal tumor of spinal cord",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4608,
        5210
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025336",
          "MEDGEN:1389203",
          "NCIT:C131526",
          "UMLS:C4318747"
        ],
        "synonyms": [
          "ependymal tumor of spinal cord",
          "spinal cord ependymal tumor",
          "spinal cord ependymal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An ependymal tumor that arises from the spinal cord."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021546"
    },
    {
      "id": 22762,
      "label": "RELA fusion-positive ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5210
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080892",
          "GARD:0022210",
          "MEDGEN:927113",
          "NCIT:C129351",
          "Orphanet:530792",
          "UMLS:C4289581"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0033980"
    }
  ],
  "roots": [
    {
      "id": 20287,
      "label": "glioma"
    }
  ]
}