{
  "id": 5249,
  "label": "pleural mesothelioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003308",
  "properties": {
    "xrefs": [
      "DOID:5157",
      "EFO:1000485",
      "HP:0100002",
      "ICD10CM:C45.0",
      "MEDGEN:237179",
      "NCIT:C9351",
      "ONCOTREE:PLMESO",
      "SCTID:109372009",
      "UMLS:C1377913"
    ],
    "synonyms": [
      "mesothelioma of pleura",
      "mesothelioma of the pleura",
      "pleura mesothelioma",
      "pleural mesothelioma",
      "pleural mesothelioma (disease)",
      "benign pleural mesothelioma",
      "pleural mesothelioma (disease), benign"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A neoplasm that arises from the mesothelial cells of the pleura. The primary cause is exposure to asbestos. The major histologic variants are the epithelioid malignant mesothelioma, desmoplastic malignant mesothelioma, and sarcomatoid malignant mesothelioma. Patients present with persistent cough and shortness of breath."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6794,
      "label": "mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8299
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000588",
          "ICD10CM:C45",
          "MEDGEN:9975",
          "MESH:D008654",
          "NCIT:C3234",
          "UMLS:C0025500"
        ],
        "synonyms": [
          "mesothelioma"
        ],
        "definition": "A usually malignant and aggressive neoplasm of the mesothelium which is often associated with exposure to asbestos."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005065"
    },
    {
      "id": 20306,
      "label": "pleural neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4184,
        20056
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:18523",
          "MESH:D010997",
          "NCIT:C3332",
          "ONCOTREE:PLEURA",
          "SCTID:126719004",
          "UMLS:C0032229"
        ],
        "synonyms": [
          "neoplasm of pleura",
          "neoplasm of pleural cavity",
          "neoplasm of the pleura",
          "pleura neoplasm",
          "pleura neoplasm (disease)",
          "pleura tumor",
          "pleura tumour",
          "pleural cavity neoplasm (disease)",
          "pleural cavity tumor",
          "pleural cavity tumour",
          "pleural neoplasm",
          "pleural tumor",
          "pleural tumour",
          "tumor of pleura",
          "tumor of the pleura",
          "tumour of pleura",
          "tumour of the pleura"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that involves the serous membrane that lines the lungs and thoracic cavity. Most pleural neoplasms are metastatic. Diffuse malignant mesothelioma is the most common primary malignant neoplasm of the pleura."
      },
      "child_count": 10,
      "reference_id": "MONDO:0021065"
    }
  ],
  "children": [
    {
      "id": 6838,
      "label": "malignant pleural mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5249,
        7834,
        7835
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7474",
          "EFO:0000770",
          "GARD:0024150",
          "MEDGEN:208810",
          "NCIT:C7376",
          "SCTID:254645002",
          "UMLS:C0812413"
        ],
        "synonyms": [
          "pleura mesothelioma",
          "malignant mesothelioma of pleura",
          "malignant mesothelioma of the pleura",
          "malignant pleural mesothelioma",
          "pleural diffuse malignant mesothelioma",
          "pleural malignant mesothelioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from mesothelial cells in the pleura and shows a diffuse growth pattern. It arises on the parietal and sometimes visceral pleura as multiple small nodules that later become confluent and invade the chest wall adipose tissue and muscle. Asbestos exposure is the main cause for the development of pleural malignant mesothelioma. It usually affects patients over sixty years of age. The latency period is long. Patients usually present with pleural effusion, dyspnea and chest wall pain. Additional signs and symptoms include chills, sweating, weight loss, and weakness. Morphologic variants include epithelioid, desmoplastic, sarcomatoid, and biphasic mesothelioma. The clinical course is usually aggressive."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005112"
    },
    {
      "id": 21357,
      "label": "pleural adenomatoid tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4471,
        5249,
        6051,
        20579
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027129",
          "MEDGEN:83408",
          "NCIT:C4499",
          "Orphanet:675814",
          "UMLS:C0346112"
        ],
        "synonyms": [
          "benign mesothelioma of pleura",
          "benign mesothelioma of the pleura",
          "pleura adenomatoid tumor",
          "pleura adenomatoid tumour",
          "pleural adenomatoid tumor",
          "pleural benign mesothelioma",
          "pleural mesothelioma, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare benign neoplasm that arises from the mesothelial cells of the pleura. It is characterized by a proliferation of epithelioid cells forming glandular and tubular patterns in a fibrous stroma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024326"
    }
  ],
  "roots": [
    {
      "id": 6794,
      "label": "mesothelioma"
    },
    {
      "id": 20306,
      "label": "pleural neoplasm"
    }
  ]
}