{
  "id": 5270,
  "label": "malignant struma ovarii",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003332",
  "properties": {
    "xrefs": [
      "DOID:5208",
      "GARD:0023454",
      "ICDO:9090/3",
      "MEDGEN:137777",
      "NCIT:C4291",
      "UMLS:C0334525"
    ],
    "synonyms": [
      "struma ovarii, malignant",
      "struma ovarii, malignant (morphologic abnormality)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An ovarian mature teratoma characterized by the presence of aberrant thyroid tissue with morphologic changes identical to thyroid carcinoma. Patients may present with abdominal mass and unusual symptoms due to thyrotoxicosis, or with Meigs syndrome (ascites and pleural effusion)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7952,
      "label": "teratoma with malignant transformation",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4656
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081246",
          "EFO:1000563",
          "GARD:0010646",
          "ICDO:9084/3",
          "MEDGEN:87256",
          "NANDO:2200107",
          "NCIT:C4289",
          "ONCOTREE:TMT",
          "UMLS:C0334523"
        ],
        "synonyms": [
          "dermoid cyst with malignant transformation",
          "teratoma with malignant transformation",
          "TMT"
        ],
        "definition": "A teratoma which is characterized by morphologic transformation to malignancy and an aggressive clinical course. The malignant component most often is sarcomatous or carcinomatous."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006444"
    },
    {
      "id": 8405,
      "label": "struma ovarii",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4470
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2640",
          "EFO:1001192",
          "GARD:0024509",
          "ICDO:9090/0",
          "MEDGEN:20977",
          "MESH:D013330",
          "NCIT:C7468",
          "UMLS:C0038478",
          "icd11.foundation:185581438"
        ],
        "synonyms": [
          "struma ovarii",
          "struma ovarii (morphologic abnormality)",
          "struma ovarii NOS (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An ovarian mature teratoma characterized by the presence of aberrant thyroid tissue. The aberrant thyroid tissue shows morphologic changes identical to thyroid adenoma or carcinoma. Patients may present with abdominal mass and unusual symptoms due to thyrotoxicosis, or Meigs syndrome (ascites and pleural effusion)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006980"
    },
    {
      "id": 18450,
      "label": "immature ovarian teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5427,
        5691,
        16723
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6331",
          "GARD:0021654",
          "MEDGEN:138044",
          "NCIT:C39995",
          "NCIT:C8111",
          "ONCOTREE:OIMT",
          "Orphanet:398987",
          "SCTID:254871000",
          "UMLS:C0346182",
          "icd11.foundation:551209361"
        ],
        "synonyms": [
          "immature germ cell teratoma of ovary",
          "immature germ cell teratoma of the ovary",
          "immature ovarian teratoma",
          "immature teratoma of ovary",
          "immature teratoma of the ovary",
          "malignant germ cell teratoma of ovary",
          "malignant germ cell teratoma of the ovary",
          "malignant ovarian germ cell teratoma",
          "malignant ovarian teratoma",
          "malignant teratoma of ovary",
          "malignant teratoma of the ovary",
          "ovarian germ cell immature teratoma",
          "ovarian immature germ cell teratoma",
          "ovarian immature teratoma",
          "ovarian malignant teratoma",
          "ovary malignant teratoma",
          "immature teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor arising from the ovary. It usually affects females in their first two decades of life. It contains variable amounts of immature embryonal tissues. Based on the amount of immature neuroepithelial component, immature teratomas are graded from 1 to 3. The stage and grade of the tumor and the grade of the metastatic tumor are the important factors that predict prognosis. The use of cisplatin-based combination chemotherapy has significantly improved the survival rates of the patients."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018369"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7952,
      "label": "teratoma with malignant transformation"
    },
    {
      "id": 8405,
      "label": "struma ovarii"
    },
    {
      "id": 18450,
      "label": "immature ovarian teratoma"
    }
  ]
}