{
  "id": 5281,
  "label": "central nervous system vasculitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003346",
  "properties": {
    "xrefs": [
      "DOID:525",
      "GARD:0023462",
      "MEDGEN:148408",
      "MESH:D020293",
      "NCIT:C84622",
      "UMLS:C0751878"
    ],
    "synonyms": [
      "central nervous system vasculitis",
      "vasculitis of central nervous system"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Vasculitis affecting the blood vessels of the brain and/or spinal cord."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 4657,
      "label": "central nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:331",
          "EFO:0009386",
          "MEDGEN:892343",
          "MESH:D002493",
          "NCIT:C2934",
          "SCTID:23853001",
          "UMLS:C4021765"
        ],
        "synonyms": [
          "CNS disorder",
          "central nervous disease",
          "central nervous system disease",
          "central nervous system disease or disorder",
          "central nervous system disorder",
          "disease of central nervous system",
          "disease of the central nervous system",
          "disease or disorder of central nervous system",
          "disorder of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease involving the central nervous system."
      },
      "child_count": 19,
      "reference_id": "MONDO:0002602"
    },
    {
      "id": 18813,
      "label": "vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7065,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:865",
          "EFO:0006803",
          "GARD:0018844",
          "MEDGEN:12054",
          "MESH:D014657",
          "MedDRA:10036023",
          "MedDRA:10047115",
          "NCIT:C26912",
          "Orphanet:52759",
          "SCTID:31996006",
          "UMLS:C0042384",
          "Wikipedia:Vasculitis",
          "icd11.foundation:572581721"
        ],
        "synonyms": [
          "systemic vasculitis",
          "angiitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behcet disease) to relatively minor skin disease."
      },
      "child_count": 36,
      "reference_id": "MONDO:0018882"
    },
    {
      "id": 23165,
      "label": "neurovascular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799,
        7065
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:857738",
          "NCIT:C117007",
          "UMLS:C3898144"
        ],
        "synonyms": [
          "disease of nervous system vasculature",
          "nervous system disorder of vasculature",
          "neurovascular disorder",
          "vasculature nervous system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disorder of the nervous system related to a vascular etiology."
      },
      "child_count": 58,
      "reference_id": "MONDO:0043218"
    }
  ],
  "children": [
    {
      "id": 3512,
      "label": "cerebral arteritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5281,
        12183,
        23218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11390",
          "GARD:0022913",
          "ICD9:437.4",
          "MEDGEN:507535",
          "SCTID:28366008",
          "UMLS:C0007773"
        ],
        "synonyms": [
          "cerebral artery inflammation",
          "inflammation of cerebral artery"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An inflammatory disease involving a pathogenic inflammatory response in the cerebral artery."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001277"
    },
    {
      "id": 7326,
      "label": "central nervous system AIDS arteritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5281,
        6835,
        21351
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024219",
          "MEDGEN:156263",
          "MESH:D020943",
          "UMLS:C0752330"
        ],
        "synonyms": [
          "AIDS associated cerebral aneurysmal arteriopathy",
          "AIDS-associated cerebral aneurysmal arteriopathy",
          "CNS Vasculitides, HIV-1-associated",
          "CNS Vasculitides, HIV-associated",
          "CNS vasculitis, HIV associated",
          "CNS vasculitis, HIV-1-associated",
          "CNS vasculitis, HIV-associated",
          "HIV 1 associated CNS vasculitis",
          "HIV associated vasculitis of the central nervous system",
          "HIV-1-associated CNS Vasculitides",
          "HIV-1-associated CNS vasculitis",
          "HIV-associated CNS Vasculitides",
          "HIV-associated CNS vasculitis",
          "HIV-associated vasculitis of the central nervous system",
          "Vasculitides, HIV-1-associated CNS",
          "Vasculitides, HIV-associated CNS",
          "central nervous system AIDS arteritis",
          "cerebral aneurysmal arteriopathy, AIDS associated",
          "cerebral aneurysmal arteriopathy, AIDS-associated",
          "vasculitis of the central nervous system, HIV associated",
          "vasculitis of the central nervous system, HIV-associated",
          "vasculitis, HIV-1-associated CNS",
          "vasculitis, HIV-associated CNS"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Inflammation of arteries in the central nervous system that occurs in patients with acquired immunodeficiency syndrome or aids-related opportunistic infections."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005695"
    },
    {
      "id": 9828,
      "label": "temporal arteritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4444,
        5281
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13375",
          "EFO:1001209",
          "GARD:0009615",
          "ICD9:446.5",
          "MEDGEN:365495",
          "MedDRA:10018250",
          "MedDRA:10043207",
          "NANDO:1200258",
          "NANDO:1200259",
          "NANDO:1200260",
          "NCIT:C35065",
          "NORD:805",
          "OMIM:187360",
          "Orphanet:397",
          "SCTID:400130008",
          "UMLS:C1956391",
          "icd11.foundation:1929970386"
        ],
        "synonyms": [
          "Giant Cell Arteritis",
          "Horton disease",
          "giant cell arteritis",
          "inflammation of temporal artery",
          "temporal arteritis",
          "temporal artery inflammation",
          "GCA",
          "Horton's arteritis",
          "Horton's giant cell arteritis",
          "Horton's temporal arteritis",
          "Horton’s disease",
          "Horton’s syndrome",
          "arteritis cranialis",
          "arteritis temporalis",
          "cranial arteritis",
          "polymyalgia rheumatica"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries."
      },
      "child_count": 2,
      "reference_id": "MONDO:0008538"
    },
    {
      "id": 16228,
      "label": "primary central nervous system vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5281
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008703",
          "MEDGEN:419271",
          "MESH:C537295",
          "Orphanet:140989",
          "UMLS:C2930862",
          "icd11.foundation:2130738127"
        ],
        "synonyms": [
          "PACNS",
          "PCNSV",
          "isolated angiitis of the central nervous system",
          "primary angiitis of the central nervous system",
          "primary central nervous system vasculitis",
          "primary vasculitis of the central nervous system",
          "granulomatous angiitis of the central nervous system",
          "primary CNS vasculitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0015374"
    },
    {
      "id": 20889,
      "label": "benign angiitis of the central nervous system",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5281
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008704"
        ],
        "synonyms": [
          "BACNS"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A central nervous system vasculitis that has a benign course, with acute onset of neurologic symptoms, usually in the form of severe headache and/or a focal neurologic event."
      },
      "child_count": 0,
      "reference_id": "MONDO:0022559"
    }
  ],
  "roots": [
    {
      "id": 4657,
      "label": "central nervous system disorder"
    },
    {
      "id": 18813,
      "label": "vasculitis"
    },
    {
      "id": 23165,
      "label": "neurovascular disorder"
    }
  ]
}