{
  "id": 5314,
  "label": "pituitary gland disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003381",
  "properties": {
    "xrefs": [
      "DOID:53",
      "EFO:0009607",
      "ICD9:253.1",
      "ICD9:253.8",
      "ICD9:253.9",
      "MEDGEN:45934",
      "MESH:D010900",
      "NCIT:C26854",
      "SCTID:399244003",
      "UMLS:C0032002"
    ],
    "synonyms": [
      "disease of pituitary gland",
      "disease or disorder of pituitary gland",
      "disorder of pituitary gland",
      "pituitary gland disease",
      "pituitary gland disease or disorder",
      "pituitary gland disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A disease involving the pituitary gland."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 6772,
      "label": "reproductive system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:15",
          "EFO:0000512",
          "MEDGEN:61253",
          "NCIT:C4875",
          "SCTID:362968007",
          "UMLS:C0178829",
          "Wikipedia:Reproductive_system_disease"
        ],
        "synonyms": [
          "disease of reproductive system",
          "disease or disorder of reproductive system",
          "disorder of reproductive system",
          "genital disorders",
          "reproductive disease",
          "reproductive system disease",
          "reproductive system disease or disorder",
          "reproductive system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A disease involving the reproductive system."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005039"
    },
    {
      "id": 6875,
      "label": "endocrine system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:28",
          "EFO:0001379",
          "ICD9:259.8",
          "ICD9:259.9",
          "MEDGEN:4043",
          "MESH:D004700",
          "NANDO:1100009",
          "NANDO:2100109",
          "NCIT:C3009",
          "SCTID:362969004",
          "UMLS:C0014130"
        ],
        "synonyms": [
          "disease of endocrine system",
          "disease or disorder of endocrine system",
          "disorder of endocrine system",
          "endocrine disease",
          "endocrine disorder",
          "endocrine system disease",
          "endocrine system disease or disorder",
          "endocrine system disorder",
          "endocrinopathy",
          "thyroid or other glandular disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the endocrine system."
      },
      "child_count": 48,
      "reference_id": "MONDO:0005151"
    },
    {
      "id": 7209,
      "label": "brain disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:936",
          "EFO:0005774",
          "ICD9:348.3",
          "ICD9:348.30",
          "ICD9:348.8",
          "ICD9:348.9",
          "MEDGEN:14214",
          "MESH:D001927",
          "NCIT:C96413",
          "SCTID:81308009",
          "UMLS:C0006111"
        ],
        "synonyms": [
          "brain disease",
          "brain disease or disorder",
          "disease of brain",
          "disease or disorder of brain",
          "disorder of brain",
          "encephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease affecting the brain or part of the brain."
      },
      "child_count": 71,
      "reference_id": "MONDO:0005560"
    }
  ],
  "children": [
    {
      "id": 4760,
      "label": "necrosis of pituitary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3646",
          "MEDGEN:124404",
          "NCIT:C27066",
          "SCTID:59572000",
          "UMLS:C0271558"
        ],
        "synonyms": [
          "pituitary gland Necrosis",
          "pituitary necrosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Ischemic or hemorrhagic necrosis of the pituitary gland."
      },
      "child_count": 1,
      "reference_id": "MONDO:0002721"
    },
    {
      "id": 6023,
      "label": "pituitary hypoplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7378",
          "MEDGEN:215300",
          "NCIT:C27343",
          "UMLS:C0948740"
        ],
        "synonyms": [
          "pituitary hypoplasia",
          "pituitary gland hypoplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Incomplete development of the pituitary gland."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004201"
    },
    {
      "id": 6876,
      "label": "hypopituitarism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9406",
          "EFO:0001380",
          "ICD10CM:E23.0",
          "MEDGEN:9386",
          "MESH:D007018",
          "NANDO:1200387",
          "NANDO:2100110",
          "NCIT:C62591",
          "SCTID:74728003",
          "UMLS:C0020635",
          "icd11.foundation:768216194"
        ],
        "synonyms": [
          "pituitary insufficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005152"
    },
    {
      "id": 8197,
      "label": "empty sella syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        5314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3642",
          "EFO:1000914",
          "GARD:0027764",
          "ICD9:253.8",
          "MEDGEN:41766",
          "MESH:D004652",
          "MedDRA:10014567",
          "NCIT:C84686",
          "SCTID:237722004",
          "UMLS:C0014008",
          "icd11.foundation:49112094"
        ],
        "synonyms": [
          "empty sella",
          "empty sella syndrome",
          "empty sella turcica"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Empty sella syndrome (ESS) is a condition that involves the sella turcica, a bony structure at the base of the brain that protects the pituitary gland. There is a primary and secondary form of the condition. The primary form occurs when a structural defect above the pituitary gland increases pressure in the sella turcica and causes the gland to flatten. The secondary form occurs when the pituitary gland is damaged due to injury, a tumor, surgery or radiation therapy. Some people with ESS have no symptoms. People with secondary ESS may have symptoms of decreased pituitary function such as absence of menstruation, infertility, fatigue, and intolerance to stress and infection. In children, ESS may be associated with early onset of puberty, growth hormone deficiency, pituitary tumors, or pituitary gland dysfunction. Treatment focuses on the symptoms present in each person."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006740"
    },
    {
      "id": 8250,
      "label": "inappropriate ADH syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5314,
        23552
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3401",
          "EFO:1000982",
          "ICD10CM:E22.2",
          "ICD9:253.6",
          "MEDGEN:5772",
          "MESH:D007177",
          "MedDRA:10042818",
          "NANDO:1200376",
          "NANDO:2100116",
          "NANDO:2200323",
          "NCIT:C3988",
          "Orphanet:83449",
          "SCTID:55004003",
          "UMLS:C0021141"
        ],
        "synonyms": [
          "SIADH",
          "ectopic ADH secretion",
          "ectopic antidiuretic hormone secretion",
          "inappropriate ADH secretion",
          "inappropriate Arginine vasopressin secretion",
          "inappropriate antidiuretic hormone secretion syndrome",
          "syndrome of inappropriate antidiuretic hormone",
          "syndrome of inappropriate antidiuretic hormone secretion",
          "syndrome of inappropriate secretion of antidiuretic hormone",
          "syndrome of inappropriate vasopressin secretion"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006802"
    },
    {
      "id": 8840,
      "label": "neurohypophyseal diabetes insipidus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        5314,
        6550,
        16543,
        23932,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12388",
          "GARD:0016629",
          "MEDGEN:574999",
          "NANDO:2201050",
          "NCIT:C84933",
          "OMIM:125700",
          "Orphanet:30925",
          "SCTID:45369008",
          "UMLS:C0342394",
          "icd11.foundation:97299603"
        ],
        "synonyms": [
          "ADH deficiency",
          "AVP deficiency",
          "Arginine vasopressin deficiency",
          "antidiuretic hormone deficiency",
          "diabetes insipidus of pituitary gland",
          "hereditary CDI",
          "hereditary neurogenic diabetes insipidus",
          "pituitary gland diabetes insipidus",
          "vasopressin deficiency",
          "diabetes insipidus, cranial type",
          "diabetes insipidus, neurohypophyseal",
          "diabetes insipidus, primary central",
          "hereditary central diabetes insipidus",
          "neurogenic diabetes insipidus"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Hereditary central diabetes insipidus is a rare genetic subtype of central diabetes insipidus (CDI) characterized by polyuria and polydipsia due to a deficiency in vasopressin (AVP) synthesis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007450"
    },
    {
      "id": 17888,
      "label": "pituitary tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        4759,
        5314,
        7638,
        8247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021253",
          "ICD9:239.7",
          "MEDGEN:19326",
          "NCIT:C3330",
          "Orphanet:304055",
          "SCTID:127024001",
          "UMLS:C0032019"
        ],
        "synonyms": [
          "neoplasm of pituitary",
          "neoplasm of pituitary gland",
          "neoplasm of the pituitary",
          "neoplasm of the pituitary gland",
          "pituitary gland neoplasm",
          "pituitary gland tumor",
          "pituitary gland tumour",
          "pituitary neoplasm",
          "pituitary tumor",
          "tumor of pituitary",
          "tumor of pituitary gland",
          "tumor of the pituitary",
          "tumor of the pituitary gland",
          "tumour of pituitary",
          "tumour of pituitary gland",
          "tumour of the pituitary",
          "tumour of the pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the pituitary gland. The vast majority are adenomas arising from the anterior lobe of the pituitary gland."
      },
      "child_count": 45,
      "reference_id": "MONDO:0017611"
    },
    {
      "id": 20389,
      "label": "hypophysitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5314,
        6880
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:575012",
          "MESH:D000072659",
          "NCIT:C12399",
          "SCTID:237705001",
          "UMLS:C0342409",
          "icd11.foundation:1589682285"
        ],
        "synonyms": [
          "gland, pituitary",
          "hypophysis",
          "hypophysis cerebri",
          "hypophysitides",
          "inflammation of pituitary gland",
          "nervous system, pituitary",
          "pituitary",
          "pituitary gland",
          "pituitary gland inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Inflammation of the pituitary gland."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021156"
    },
    {
      "id": 21424,
      "label": "anterior pituitary gland disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:253.4",
          "ICD9:253.9",
          "MEDGEN:148306",
          "SCTID:51742006",
          "UMLS:C0751437"
        ],
        "synonyms": [
          "adenohypophysis disease",
          "adenohypophysis disease or disorder",
          "disease of adenohypophysis",
          "disease or disorder of adenohypophysis",
          "disorder of adenohypophysis",
          "disorder of anterior pituitary",
          "disorder of anterior pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease that involves the adenohypophysis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0024468"
    }
  ],
  "roots": [
    {
      "id": 6772,
      "label": "reproductive system disorder"
    },
    {
      "id": 6875,
      "label": "endocrine system disorder"
    },
    {
      "id": 7209,
      "label": "brain disorder"
    }
  ]
}