{
  "id": 5327,
  "label": "testicular granulosa cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003395",
  "properties": {
    "xrefs": [
      "DOID:5331",
      "GARD:0023498",
      "MEDGEN:237001",
      "NCIT:C6357",
      "UMLS:C1336709"
    ],
    "synonyms": [
      "granulosa cell tumor of testis",
      "testicular granulosa cell tumor",
      "testis granulosa cell tumor",
      "testis granulosa cell tumour",
      "granulosa cell neoplasm of testis",
      "granulosa cell neoplasm of the testis",
      "granulosa cell tumor of the testis",
      "granulosa cell tumour of the testis",
      "testicular granulosa cell neoplasm"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A rare sex cord-stromal tumor that arises from the testis. It is characterized by the presence of granulosa-like cells and Call-Exner bodies. There are two variants described, the adult and the juvenile."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 5102,
      "label": "testicular sex cord-stromal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639,
        20517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4757",
          "GARD:0021551",
          "MEDGEN:825921",
          "NCIT:C6358",
          "Orphanet:363489",
          "SCTID:702406000",
          "UMLS:C3840076"
        ],
        "synonyms": [
          "sex cord-stromal tumor of testis",
          "sex cord-stromal tumour of testis",
          "testicular sex cord-stromal neoplasm",
          "testicular sex cord-stromal tumor",
          "testicular sex cord-stromal tumour",
          "testis sex cord-stromal tumor",
          "testis sex cord-stromal tumour",
          "sex cord-stromal neoplasm",
          "sex cord-stromal neoplasm of testis",
          "sex cord-stromal neoplasm of the testis",
          "sex cord-stromal tumor of the testis",
          "sex cord-stromal tumour of the testis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant tumor that arises from the testis. It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the tumor or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, ten percent of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group."
      },
      "child_count": 20,
      "reference_id": "MONDO:0003125"
    },
    {
      "id": 7622,
      "label": "granulosa cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2999",
          "EFO:1000032",
          "MEDGEN:6676",
          "MESH:D006106",
          "NCIT:C3070",
          "ONCOTREE:GRCT",
          "UMLS:C0018206"
        ],
        "synonyms": [
          "granulosa cell neoplasm",
          "granulosa cell neoplasm (disease)",
          "granulosa cell tumor",
          "granulosa cell tumor, adult type (morphologic abnormality)",
          "granulosa cell tumor, sarcomatoid",
          "neoplasm of granulosa cell",
          "tumor of granulosa cell",
          "tumour of granulosa cell",
          "GRCT",
          "granulosa cell tumor, undetermined"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A slow-growing, malignant tumor, characterize by the presence of granulosa-like cells and Call-Exner bodies, that is almost always found in the ovary. In rare cases, it has also been found in the testicle. There are two types of granulosa cell tumor that can be distinguished under the microscope: the adult and the juvenile. The testicular juvenile granulosa cell tumors are perhaps the most common congenital testicular neoplasms."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006036"
    }
  ],
  "children": [
    {
      "id": 5621,
      "label": "juvenile type testicular granulosa cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5327
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6032",
          "GARD:0023644",
          "MEDGEN:308257",
          "NCIT:C39947",
          "UMLS:C1515285"
        ],
        "synonyms": [
          "juvenile granulosa cell tumor",
          "juvenile granulosa cell tumor (morphologic abnormality)",
          "juvenile granulosa cell tumour",
          "juvenile granulosa cell tumour (morphologic abnormality)",
          "juvenile type granulosa cell neoplasm",
          "juvenile type granulosa cell tumor",
          "juvenile type granulosa cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare sex cord-stromal tumor that arises from the testis. It is the most frequent congenital testicular neoplasm and is usually diagnosed during the perinatal period. It usually presents as an asymptomatic scrotal or abdominal mass. Morphologically it is characterized by the presence of cysts that are lined by cells resembling granulosa and theca cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003741"
    },
    {
      "id": 6347,
      "label": "adult type testicular granulosa cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5327
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8394",
          "GARD:0024062",
          "MEDGEN:272840",
          "NCIT:C39946",
          "UMLS:C1515284"
        ],
        "synonyms": [
          "adult testicular granulosa cell tumor",
          "adult testicular granulosa cell tumour",
          "adult type testicular granulosa cell tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare sex cord-stromal tumor that arises from the testis in adults. Gynecomastia is present in approximately a quarter of the patients. Several morphologic patterns have been identified and include insular, gyriform, trabecular, pseudosarcomatous, and solid. Metastases occur in approximately twenty percent of the cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004548"
    }
  ],
  "roots": [
    {
      "id": 5102,
      "label": "testicular sex cord-stromal neoplasm"
    },
    {
      "id": 7622,
      "label": "granulosa cell tumor"
    }
  ]
}