{
  "id": 5334,
  "label": "testicular yolk sac tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003402",
  "properties": {
    "xrefs": [
      "DOID:5344",
      "EFO:1000574",
      "GARD:0023502",
      "MEDGEN:79028",
      "NCIT:C8000",
      "ONCOTREE:TYST",
      "UMLS:C0279708"
    ],
    "synonyms": [
      "testicular yolk Sac neoplasm",
      "testicular yolk sac tumor",
      "testis yolk sac tumor",
      "testis yolk sac tumour",
      "Orchidoblastoma",
      "endodermal sinus neoplasm of testis",
      "endodermal sinus neoplasm of the testis",
      "endodermal sinus tumor of testis",
      "endodermal sinus tumor of the testis",
      "endodermal sinus tumour of testis",
      "endodermal sinus tumour of the testis",
      "endodermal-sinus tumor",
      "endodermal-sinus tumour",
      "testicular endodermal sinus neoplasm",
      "testicular endodermal sinus tumor",
      "testicular endodermal sinus tumour",
      "yolk Sac neoplasm of testis",
      "yolk Sac neoplasm of the testis",
      "yolk Sac tumor of testis",
      "yolk Sac tumor of the testis",
      "yolk Sac tumour of testis",
      "yolk Sac tumour of the testis",
      "yolk sac tumor",
      "yolk sac tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A non-seminomatous malignant germ cell tumor arising from the testis. It affects infants, young children, and postpubertal males. It is the most frequently seen testicular neoplasm during childhood. The vast majority of patients present with an asymptomatic scrotal mass. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). It metastasizes to distant anatomic sites. Prognostic factors relate to the clinical stage and the degree of AFP elevation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 4887,
      "label": "testicular pure germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11294
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4087",
          "GARD:0023284",
          "MEDGEN:308089",
          "NCIT:C39915",
          "UMLS:C1514608"
        ],
        "synonyms": [
          "testicular Pure germ cell tumor",
          "testicular Pure germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A germ cell tumor that arises from the testis and is characterized by the presence of one histologic component. This category includes seminoma, teratoma, embryonal carcinoma, yolk sac tumor, and trophoblastic tumor."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002874"
    },
    {
      "id": 5335,
      "label": "testicular non-seminomatous germ cell cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5424,
        7954
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5345",
          "GARD:0023503",
          "MEDGEN:233162",
          "NCIT:C5027",
          "UMLS:C1334625"
        ],
        "synonyms": [
          "malignant non-seminomatous germ cell cancer of testis",
          "malignant non-seminomatous germ cell cancer of the testis",
          "malignant non-seminomatous germ cell neoplasm of testis",
          "malignant non-seminomatous germ cell neoplasm of the testis",
          "malignant non-seminomatous germ cell tumor of testis",
          "malignant non-seminomatous germ cell tumor of the testis",
          "malignant non-seminomatous germ cell tumour of testis",
          "malignant non-seminomatous germ cell tumour of the testis",
          "malignant testicular non-seminomatous germ cell neoplasm",
          "malignant testicular non-seminomatous germ cell tumor",
          "malignant testicular non-seminomatous germ cell tumour",
          "testicular germ cell tumor non-seminomatous, malignant",
          "testicular germ cell tumour non-seminomatous, malignant",
          "testicular non-seminomatous germ cell cancer",
          "testicular non-seminomatous germ cell tumor, malignant",
          "testicular non-seminomatous malignant germ cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A classification of testicular cancers that arise in specialized sex cells called germ cells. Nonseminomas include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac tumor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003403"
    },
    {
      "id": 7365,
      "label": "yolk sac tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5475
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1911",
          "EFO:0007252",
          "GARD:0000348",
          "ICDO:9071/3",
          "MEDGEN:41782",
          "MedDRA:10048251",
          "NANDO:2200069",
          "NCIT:C3011",
          "ONCOTREE:BYST",
          "Orphanet:876",
          "SCTID:404081005",
          "UMLS:C0014145"
        ],
        "synonyms": [
          "endodermal sinus neoplasm",
          "endodermal sinus tumor",
          "hepatoid yolk sac tumor",
          "yolk SAC tumor, malignant",
          "yolk Sac neoplasm",
          "yolk Sac tumor",
          "yolk Sac tumor site unspecified",
          "yolk Sac tumour site unspecified",
          "yolk sac tumor",
          "infantile embryonal carcinoma"
        ],
        "definition": "A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005744"
    }
  ],
  "children": [
    {
      "id": 5940,
      "label": "testicular yolk sac tumor, macrocystic pattern",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7097",
          "GARD:0023827",
          "MEDGEN:271772",
          "NCIT:C39924",
          "UMLS:C1515307"
        ],
        "synonyms": [
          "testicular yolk sac tumor, macrocystic pattern",
          "macrocystic pattern testicular yolk sac tumor",
          "macrocystic pattern testicular yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the testis and is characterized by the presence of collections of thin-walled spaces."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004106"
    },
    {
      "id": 6001,
      "label": "testicular yolk sac tumor, endodermal sinus pattern",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7302",
          "GARD:0023864",
          "MEDGEN:273636",
          "NCIT:C39927",
          "UMLS:C1515303"
        ],
        "synonyms": [
          "testicular yolk sac tumor, endodermal sinus pattern",
          "endodermal sinus pattern testicular yolk sac tumor",
          "endodermal sinus pattern testicular yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the testis and is characterized by the presence of connective tissue stalks that contain a blood vessel and are lined by cells with clear cytoplasm and prominent nucleoli."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004178"
    },
    {
      "id": 6020,
      "label": "testicular yolk sac tumor, solid pattern",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7360",
          "GARD:0023871",
          "MEDGEN:308263",
          "NCIT:C39925",
          "UMLS:C1515312"
        ],
        "synonyms": [
          "testicular yolk sac tumor, solid pattern",
          "solid pattern testicular yolk sac tumor",
          "solid pattern testicular yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the testis and is characterized by the presence of aggregates of polygonal malignant cells with clear cytoplasm and prominent nucleoli."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004198"
    },
    {
      "id": 6041,
      "label": "polyvesicular vitelline pattern testicular yolk sac tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7435",
          "GARD:0023884",
          "MEDGEN:273638",
          "NCIT:C39930",
          "UMLS:C1515311"
        ],
        "synonyms": [
          "testicular yolk Sac tumor, polyvesicular vitelline pattern"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the testis and is characterized by the presence of collections of vesicles that are surrounded by connective tissue."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004219"
    },
    {
      "id": 6211,
      "label": "testicular yolk sac tumor, glandular-alveolar pattern",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7930",
          "GARD:0023981",
          "MEDGEN:273637",
          "NCIT:C39926",
          "UMLS:C1515305"
        ],
        "synonyms": [
          "testicular yolk sac tumor, glandular-alveolar pattern",
          "glandular-alveolar pattern testicular yolk sac tumor",
          "glandular-alveolar pattern testicular yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the testis and is characterized by the presence of gland-like spaces, irregular alveoli, and tubular structures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004402"
    },
    {
      "id": 6259,
      "label": "testicular yolk sac tumor, myxomatous pattern",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8081",
          "GARD:0024014",
          "MEDGEN:271774",
          "NCIT:C39929",
          "UMLS:C1515309"
        ],
        "synonyms": [
          "testicular yolk sac tumor, myxomatous pattern",
          "myxomatous pattern testicular yolk sac tumor",
          "myxomatous pattern testicular yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the testis and is characterized by the presence of myxomatous tissue that contains collections of malignant cells with prominent nucleoli."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004453"
    },
    {
      "id": 6295,
      "label": "testicular yolk sac tumor, papillary pattern",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8193",
          "GARD:0024034",
          "MEDGEN:308262",
          "NCIT:C39928",
          "UMLS:C1515310"
        ],
        "synonyms": [
          "testicular yolk sac tumor, papillary pattern",
          "papillary pattern testicular yolk sac tumor",
          "papillary pattern testicular yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the testis and is characterized by the presence of numerous papillary structures that are lined by cells with prominent nucleoli."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004493"
    },
    {
      "id": 6296,
      "label": "testicular yolk sac tumor, hepatoid pattern",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8195",
          "GARD:0024035",
          "MEDGEN:272846",
          "NCIT:C39931",
          "UMLS:C1515306"
        ],
        "synonyms": [
          "testicular yolk sac tumor, hepatoid pattern",
          "hepatoid pattern testicular yolk sac tumor",
          "hepatoid pattern testicular yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the testis and is characterized by the presence of hepatoid cells collections."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004494"
    },
    {
      "id": 6342,
      "label": "enteric pattern testicular yolk sac tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8362",
          "GARD:0024057",
          "MEDGEN:308261",
          "NCIT:C39932",
          "UMLS:C1515304"
        ],
        "synonyms": [
          "testicular yolk Sac tumor, enteric pattern"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the testis and is characterized by the presence of immature glands."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004543"
    },
    {
      "id": 6346,
      "label": "reticular pattern testicular yolk sac tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8392",
          "GARD:0024061",
          "MEDGEN:271773",
          "NCIT:C39923",
          "UMLS:C1515308"
        ],
        "synonyms": [
          "testicular yolk Sac tumor, microcystic pattern",
          "testicular yolk Sac tumor, reticular pattern"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A yolk sac tumor that arises from the testis and is characterized by the presence of a meshwork of small vacuolated cells resulting in a honeycomb appearance."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004547"
    }
  ],
  "roots": [
    {
      "id": 4887,
      "label": "testicular pure germ cell tumor"
    },
    {
      "id": 5335,
      "label": "testicular non-seminomatous germ cell cancer"
    },
    {
      "id": 7365,
      "label": "yolk sac tumor"
    }
  ]
}