{
  "id": 5335,
  "label": "testicular non-seminomatous germ cell cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003403",
  "properties": {
    "xrefs": [
      "DOID:5345",
      "GARD:0023503",
      "MEDGEN:233162",
      "NCIT:C5027",
      "UMLS:C1334625"
    ],
    "synonyms": [
      "malignant non-seminomatous germ cell cancer of testis",
      "malignant non-seminomatous germ cell cancer of the testis",
      "malignant non-seminomatous germ cell neoplasm of testis",
      "malignant non-seminomatous germ cell neoplasm of the testis",
      "malignant non-seminomatous germ cell tumor of testis",
      "malignant non-seminomatous germ cell tumor of the testis",
      "malignant non-seminomatous germ cell tumour of testis",
      "malignant non-seminomatous germ cell tumour of the testis",
      "malignant testicular non-seminomatous germ cell neoplasm",
      "malignant testicular non-seminomatous germ cell tumor",
      "malignant testicular non-seminomatous germ cell tumour",
      "testicular germ cell tumor non-seminomatous, malignant",
      "testicular germ cell tumour non-seminomatous, malignant",
      "testicular non-seminomatous germ cell cancer",
      "testicular non-seminomatous germ cell tumor, malignant",
      "testicular non-seminomatous malignant germ cell neoplasm"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A classification of testicular cancers that arise in specialized sex cells called germ cells. Nonseminomas include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac tumor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5424,
      "label": "malignant testicular germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7111,
        7832,
        11294
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5556",
          "GARD:0023539",
          "ICD9:186.9",
          "MEDGEN:163616",
          "NCIT:C9063",
          "SCTID:713646001",
          "UMLS:C0855197"
        ],
        "synonyms": [
          "testicular cancer",
          "malignant germ cell neoplasm of testis",
          "malignant germ cell neoplasm of the testis",
          "malignant germ cell tumor of testis",
          "malignant germ cell tumor of the testis",
          "malignant germ cell tumour of testis",
          "malignant germ cell tumour of the testis",
          "malignant testicular germ cell neoplasm",
          "malignant testicular germ cell tumor",
          "testicular ca. (no germ/tropho.)",
          "testicular cancer (excluding germ cell or trophoblastic cancer)",
          "testicular germ cell cancer",
          "testicular malignant germ cell cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor predominantly affecting young men and often associated with cryptorchidism. Seminoma is the most frequently seen malignant testicular germ cell tumor, followed by embryonal carcinoma and yolk sac tumor."
      },
      "child_count": 18,
      "reference_id": "MONDO:0003510"
    },
    {
      "id": 7954,
      "label": "testicular non-seminomatous germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11294
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4086",
          "EFO:1000570",
          "GARD:0017561",
          "ICDO:9065/3",
          "MEDGEN:890627",
          "NCIT:C9313",
          "Orphanet:363494",
          "UMLS:C2057625"
        ],
        "synonyms": [
          "non-dysgerminomatous germ cell tumor of testis",
          "non-dysgerminomatous germ cell tumour of testis",
          "non-seminomatous germ cell tumor of testis",
          "non-seminomatous germ cell tumour of testis",
          "testicular germ cell tumor non-seminomatous",
          "testicular germ cell tumour non-seminomatous",
          "testicular non seminomatous germ cell tumor",
          "testicular non seminomatous germ cell tumour",
          "testicular non-dysgerminomatous germ cell tumor",
          "testicular non-dysgerminomatous germ cell tumour",
          "testicular non-seminomatous germ cell tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A testicular germ cell tumor characterized by the absence of a seminomatous component. It includes embryonal carcinoma, yolk sac tumor, choriocarcinoma, teratoma, and mixed forms."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006447"
    }
  ],
  "children": [
    {
      "id": 5334,
      "label": "testicular yolk sac tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4887,
        5335,
        7365
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5344",
          "EFO:1000574",
          "GARD:0023502",
          "MEDGEN:79028",
          "NCIT:C8000",
          "ONCOTREE:TYST",
          "UMLS:C0279708"
        ],
        "synonyms": [
          "testicular yolk Sac neoplasm",
          "testicular yolk sac tumor",
          "testis yolk sac tumor",
          "testis yolk sac tumour",
          "Orchidoblastoma",
          "endodermal sinus neoplasm of testis",
          "endodermal sinus neoplasm of the testis",
          "endodermal sinus tumor of testis",
          "endodermal sinus tumor of the testis",
          "endodermal sinus tumour of testis",
          "endodermal sinus tumour of the testis",
          "endodermal-sinus tumor",
          "endodermal-sinus tumour",
          "testicular endodermal sinus neoplasm",
          "testicular endodermal sinus tumor",
          "testicular endodermal sinus tumour",
          "yolk Sac neoplasm of testis",
          "yolk Sac neoplasm of the testis",
          "yolk Sac tumor of testis",
          "yolk Sac tumor of the testis",
          "yolk Sac tumour of testis",
          "yolk Sac tumour of the testis",
          "yolk sac tumor",
          "yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-seminomatous malignant germ cell tumor arising from the testis. It affects infants, young children, and postpubertal males. It is the most frequently seen testicular neoplasm during childhood. The vast majority of patients present with an asymptomatic scrotal mass. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). It metastasizes to distant anatomic sites. Prognostic factors relate to the clinical stage and the degree of AFP elevation."
      },
      "child_count": 30,
      "reference_id": "MONDO:0003402"
    },
    {
      "id": 5422,
      "label": "choriocarcinoma of testis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4885,
        5335,
        6924
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5551",
          "EFO:1000564",
          "GARD:0023537",
          "MEDGEN:65969",
          "NCIT:C7733",
          "ONCOTREE:TCCA",
          "UMLS:C0238449",
          "icd11.foundation:1972827817"
        ],
        "synonyms": [
          "choriocarcinoma of testis",
          "choriocarcinoma of the testis",
          "testicular choriocarcinoma",
          "testis choriocarcinoma (disease)",
          "choriocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor arising from the testis. It represents the rarest of the testicular germ cell tumors. Histologically it is characterized by the presence of syncytiotrophoblasts and cytotrophoblasts."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003508"
    },
    {
      "id": 7953,
      "label": "testicular embryonal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4887,
        5335,
        7107,
        7212
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5680",
          "EFO:1000565",
          "GARD:0024413",
          "MEDGEN:66771",
          "NCIT:C6341",
          "UMLS:C0238448"
        ],
        "synonyms": [
          "embryonal carcinoma of testis",
          "embryonal carcinoma of the testis",
          "embryonal testis carcinoma",
          "testicular embryonal carcinoma",
          "testis embryonal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell neoplasm arising from the testis. It is composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations. Most patients present with a testicular mass, which may be associated with pain. More than half of the patients have metastatic disease at diagnosis. The form of treatment following radical orchiectomy is stage dependent."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006446"
    }
  ],
  "roots": [
    {
      "id": 5424,
      "label": "malignant testicular germ cell tumor"
    },
    {
      "id": 7954,
      "label": "testicular non-seminomatous germ cell tumor"
    }
  ]
}