{
  "id": 5339,
  "label": "ovarian primitive germ cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003408",
  "properties": {
    "xrefs": [
      "DOID:5351",
      "GARD:0023506",
      "MEDGEN:275291",
      "NCIT:C39986",
      "UMLS:C1518727"
    ],
    "synonyms": [
      "ovarian primitive germ cell tumor"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant tumor that arises from the ovary and is characterized by the presence of malignant germ cell components but lacks a teratoma component."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 18315,
      "label": "malignant germ cell tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832,
        12476,
        18335,
        18448
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2155",
          "GARD:0009330",
          "MEDGEN:87544",
          "NCIT:C4514",
          "Orphanet:35807",
          "SCTID:254869000",
          "UMLS:C0346180"
        ],
        "synonyms": [
          "MOGCT",
          "malignant germ cell neoplasm of ovary",
          "malignant germ cell neoplasm of the ovary",
          "malignant germ cell tumor of ovary",
          "malignant germ cell tumor of the ovary",
          "malignant germ cell tumour of the ovary",
          "malignant ovarian germ cell neoplasm",
          "malignant ovarian germ cell tumor",
          "malignant ovarian germ cell tumour",
          "ovarian germ cell cancer",
          "ovary malignant germ cell tumor",
          "ovary malignant germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Malignant germ cell tumor of ovary is a rare ovarian cancer arising from germ cells in the ovary, frequently unilateral at diagnosis which characteristically presents during adolescence with pelvic mass, fever, vaginal bleeding and acute abdomen."
      },
      "child_count": 16,
      "reference_id": "MONDO:0018171"
    }
  ],
  "children": [
    {
      "id": 5403,
      "label": "dysgerminoma of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5001,
        5339
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5511",
          "EFO:1000414",
          "GARD:0023525",
          "MEDGEN:83414",
          "NCIT:C8106",
          "ONCOTREE:ODYS",
          "SCTID:254874008",
          "UMLS:C0346185",
          "icd11.foundation:208782658"
        ],
        "synonyms": [
          "dysgerminoma of ovary",
          "dysgerminoma of the ovary",
          "germ cell dysgerminoma of ovary",
          "germ cell dysgerminoma of the ovary",
          "ovarian dysgerminoma",
          "ovarian germ cell dysgerminoma",
          "ovary dysgerminoma (disease)",
          "dysgerminoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor arising from the ovary. Morphologically, it is identical to seminoma and consists of a monotonous population of germ cells with abundant pale cytoplasm and uniform nuclei. The stroma invariably contains chronic inflammatory cells, mostly T-lymphocytes. It responds to chemotherapy or radiotherapy and the prognosis relates to the tumor stage."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003481"
    },
    {
      "id": 5592,
      "label": "ovarian mixed germ cell neoplasm",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5339,
        16596
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5936",
          "GARD:0023629",
          "MEDGEN:83602",
          "NCIT:C8114",
          "ONCOTREE:OMGCT",
          "UMLS:C0280135"
        ],
        "synonyms": [
          "mixed germ cell neoplasm of ovary",
          "mixed germ cell neoplasm of the ovary",
          "mixed germ cell tumor of ovary",
          "mixed germ cell tumor of the ovary",
          "mixed germ cell tumour of ovary",
          "mixed germ cell tumour of the ovary",
          "ovarian mixed germ cell neoplasm",
          "ovarian mixed germ cell tumor",
          "ovarian mixed germ cell tumour",
          "ovary mixed germ cell tumor",
          "ovary mixed germ cell tumour",
          "mixed germ cell tumor",
          "mixed germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An ovarian malignant germ cell tumor characterized by the presence of at least two different germ cell components. At least one of the germ cell components is primitive. The most common combination of germ cell elements is dysgerminoma and yolk sac tumor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003710"
    },
    {
      "id": 6138,
      "label": "non-gestational ovarian choriocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5339,
        5421
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7665",
          "GARD:0023934",
          "MEDGEN:274798",
          "NCIT:C39991",
          "UMLS:C1518355"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor that arises from the ovary and is composed of cytotrophoblasts, syncytiotrophoblasts, and extravillous trophoblasts. The prognosis is less favorable than gestational choriocarcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004322"
    },
    {
      "id": 16723,
      "label": "malignant non-dysgerminomatous germ cell tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5339,
        20708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020349",
          "MEDGEN:1826164",
          "NCIT:C102870",
          "Orphanet:206538",
          "UMLS:C5679783"
        ],
        "synonyms": [
          "non-dysgerminomatous germ cell cancer of ovary",
          "ovarian Nondysgerminomatous germ cell tumor",
          "ovarian Nondysgerminomatous germ cell tumour",
          "ovarian non-dysgerminomatous germ cell tumor",
          "ovarian non-dysgerminomatous germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor other than dysgerminoma that arises from the ovary."
      },
      "child_count": 10,
      "reference_id": "MONDO:0016096"
    }
  ],
  "roots": [
    {
      "id": 18315,
      "label": "malignant germ cell tumor of ovary"
    }
  ]
}