{
  "id": 5357,
  "label": "functioning pituitary gland adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003429",
  "properties": {
    "xrefs": [
      "DOID:5395",
      "GARD:0021389",
      "MEDGEN:163135",
      "NCIT:C8388",
      "Orphanet:314753",
      "UMLS:C0854486"
    ],
    "synonyms": [
      "endocrine active pituitary adenoma",
      "functioning adenoma of pituitary",
      "functioning adenoma of pituitary gland",
      "functioning adenoma of the pituitary",
      "functioning adenoma of the pituitary gland",
      "functioning pituitary adenoma",
      "functioning pituitary gland adenoma",
      "functioning pituitary gland adenoma (benign)",
      "secreting pituitary adenoma",
      "secretory adenoma of pituitary",
      "secretory adenoma of pituitary gland",
      "secretory adenoma of the pituitary",
      "secretory adenoma of the pituitary gland",
      "secretory pituitary adenoma",
      "secretory pituitary gland adenoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A hormone producing pituitary gland adenoma, associated with a hormonal syndrome."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 5498,
      "label": "functioning pituitary gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17888,
        20359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5716",
          "GARD:0023587",
          "ICD9:237.0",
          "MEDGEN:163414",
          "NCIT:C7047",
          "SCTID:448148000",
          "UMLS:C0851693"
        ],
        "synonyms": [
          "functioning endocrine neoplasm of pituitary gland",
          "functioning pituitary gland neoplasm",
          "functioning pituitary neoplasm",
          "hormone producing pituitary neoplasm",
          "pituitary gland functioning endocrine neoplasm",
          "pituitary neoplasms, hormone producing",
          "functioning pituitary tumor",
          "functioning pituitary tumour",
          "growth hormone producing pituitary tumour",
          "hormone producing pituitary cancer",
          "secretory pituitary tumor",
          "secretory pituitary tumour",
          "somatotropinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hormone producing pituitary gland tumor, associated with a hormonal syndrome."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003604"
    },
    {
      "id": 7896,
      "label": "pituitary gland adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6714,
        17888
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3829",
          "EFO:1000478",
          "GARD:0019680",
          "ICDO:8272/0",
          "MEDGEN:45933",
          "MedDRA:10035079",
          "NANDO:2200095",
          "NCIT:C3329",
          "ONCOTREE:PTAD",
          "Orphanet:99408",
          "SCTID:254956000",
          "UMLS:C0032000"
        ],
        "synonyms": [
          "adenoma of pituitary",
          "adenoma of pituitary gland",
          "adenoma of the pituitary",
          "adenoma of the pituitary gland",
          "adenoma, anterior lobe pituitary gland, benign",
          "pituitary adenoma",
          "pituitary gland adenoma",
          "PTAD"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-metastasizing tumor that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland. The tumor can be hormonally functioning or not. The diagnosis can be based on imaging studies and/or radioimmunoassays. Due to its location in the sella turcica, expansion of the tumor mass can impinge on the optic chiasm or involve the temporal lobe, third ventricle and posterior fossa A frequently associated physical finding is bitemporal hemianopsia which may progress to further visual loss."
      },
      "child_count": 18,
      "reference_id": "MONDO:0006373"
    }
  ],
  "children": [
    {
      "id": 5705,
      "label": "TSH producing pituitary tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5357,
        16048,
        29359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6275",
          "GARD:0023689",
          "MEDGEN:391700",
          "NCIT:C7915",
          "SCTID:254959007",
          "UMLS:C2362538"
        ],
        "synonyms": [
          "TSH-producing pituitary gland tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces thyrotropin."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003837"
    },
    {
      "id": 10301,
      "label": "Cushing disease due to pituitary adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5357,
        18043,
        19975,
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7004",
          "GARD:0012867",
          "MEDGEN:66381",
          "MESH:D049913",
          "MedDRA:10035109",
          "NANDO:1200379",
          "NANDO:2200350",
          "NCIT:C113210",
          "OMIM:219090",
          "Orphanet:96253",
          "SCTID:254958004",
          "UMLS:C0221406",
          "icd11.foundation:380861892"
        ],
        "synonyms": [
          "ACTH producing pituitary adenoma",
          "Cushing disease",
          "Cushing disease, pituitary",
          "Cushing's disease",
          "PITA4",
          "corticotroph pituitary adenoma",
          "pituitary adenoma 4, ACTH-secreting",
          "pituitary adenoma 4, ACTH-secreting, somatic",
          "pituitary adenoma, ACTH-secreting",
          "pituitary corticotroph micro-adenoma",
          "pituitary dependent Cushing syndrome",
          "pituitary-dependent Cushing syndrome",
          "ACTH-secreting pituitary adenoma",
          "Corticotropinoma",
          "corticotroph adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A form of adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome, an endogenous Cushing syndrome (CS), characterized by chronic over-secretion of adrenocorticotropic hormone (ACTH) due to a pituitary corticotroph adenoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009050"
    },
    {
      "id": 16672,
      "label": "Nelson syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5357
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4968",
          "GARD:0007170",
          "ICD10CM:E24.1",
          "MEDGEN:342174",
          "MESH:C531754",
          "MESH:D009347",
          "MedDRA:10028913",
          "NCIT:C84917",
          "NORD:1492",
          "Orphanet:199244",
          "SCTID:43019009",
          "UMLS:C1852159",
          "icd11.foundation:1945677910"
        ],
        "synonyms": [
          "Nelson's syndrome",
          "Ridges-off-the-end syndrome",
          "dermal Ridges"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A syndrome that develops following bilateral adrenalectomy for Cushing syndrome. The signs and symptoms result from the presence of an adenocorticotropin-secreting pituitary gland adenoma, and include enlargement of the sella turcica and pressure on the adjacent structures, and skin hyperpigmentation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016035"
    },
    {
      "id": 18041,
      "label": "mixed functioning pituitary adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5357
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021390",
          "MEDGEN:577354",
          "Orphanet:314759",
          "SCTID:254961003",
          "UMLS:C0346305"
        ],
        "synonyms": [
          "mixed secreting pituitary adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0017822"
    },
    {
      "id": 19404,
      "label": "functioning gonadotropic adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5357
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019158",
          "MEDGEN:577353",
          "NCIT:C45915",
          "Orphanet:91348",
          "SCTID:254960002",
          "UMLS:C0346304"
        ],
        "synonyms": [
          "functioning pituitary gonadotropic adenoma",
          "gonadotroph adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Functioning gonadotropic adenoma is a very rare pituitary tumor, macroscopically characterized by a soft, well vascularized, variable sized adenoma, with occasional areas of hemorrage or necrosis, that secretes biologically active gonadotropins. In addition to common neurological signs due to mass effect (headache and/or visual field deterioration), additional clinical manifestations include menstrual irregularities (secondary amenorrhea, oligomenorhea or severe menorrhagia), galactorrhea, infertility or ovarian hyperstimulation syndrome (in premenopausal women), testicular enlargement and, occasionally, hypogonadism (in men) and isosexual precocious puberty (in children)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019612"
    }
  ],
  "roots": [
    {
      "id": 5498,
      "label": "functioning pituitary gland neoplasm"
    },
    {
      "id": 7896,
      "label": "pituitary gland adenoma"
    }
  ]
}