{
  "id": 5403,
  "label": "dysgerminoma of ovary",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003481",
  "properties": {
    "xrefs": [
      "DOID:5511",
      "EFO:1000414",
      "GARD:0023525",
      "MEDGEN:83414",
      "NCIT:C8106",
      "ONCOTREE:ODYS",
      "SCTID:254874008",
      "UMLS:C0346185",
      "icd11.foundation:208782658"
    ],
    "synonyms": [
      "dysgerminoma of ovary",
      "dysgerminoma of the ovary",
      "germ cell dysgerminoma of ovary",
      "germ cell dysgerminoma of the ovary",
      "ovarian dysgerminoma",
      "ovarian germ cell dysgerminoma",
      "ovary dysgerminoma (disease)",
      "dysgerminoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant germ cell tumor arising from the ovary. Morphologically, it is identical to seminoma and consists of a monotonous population of germ cells with abundant pale cytoplasm and uniform nuclei. The stroma invariably contains chronic inflammatory cells, mostly T-lymphocytes. It responds to chemotherapy or radiotherapy and the prognosis relates to the tumor stage."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 5001,
      "label": "dysgerminoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832,
        20017
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4441",
          "GARD:0023323",
          "HP:0100621",
          "ICDO:9060/3",
          "MEDGEN:41680",
          "MESH:D004407",
          "NANDO:2200066",
          "NCIT:C2996",
          "UMLS:C0013377",
          "icd11.foundation:817547820"
        ],
        "synonyms": [
          "dysgerminoma",
          "dysgerminoma (disease)",
          "dysgerminoma, malignant"
        ],
        "definition": "A malignant germ cell tumor characterized by the presence of a monotonous primitive germ cell population. The neoplastic cells form aggregates and have an abundant pale cytoplasm and uniform nuclei. The aggregates of the germ cells are separated by fibrous septa which contain inflammatory cells, mostly T-lymphocytes. It arises primarily in the ovaries, but can occur both primarily and secondarily at other sites, particularly the central nervous system. It responds to chemotherapy and radiotherapy. Its prognosis is related to the tumor stage."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003002"
    },
    {
      "id": 5339,
      "label": "ovarian primitive germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5351",
          "GARD:0023506",
          "MEDGEN:275291",
          "NCIT:C39986",
          "UMLS:C1518727"
        ],
        "synonyms": [
          "ovarian primitive germ cell tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor that arises from the ovary and is characterized by the presence of malignant germ cell components but lacks a teratoma component."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003408"
    }
  ],
  "children": [
    {
      "id": 6015,
      "label": "pediatric ovarian dysgerminoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5403,
        5640,
        6283,
        20015
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7340",
          "GARD:0023869",
          "MEDGEN:272465",
          "NCIT:C6550",
          "UMLS:C1332988"
        ],
        "synonyms": [
          "childhood dysgerminoma",
          "childhood dysgerminoma of ovary",
          "childhood ovarian dysgerminoma",
          "childhood ovarian germinomatous germ cell tumor",
          "childhood ovarian germinomatous germ cell tumour",
          "dysgerminoma of ovary of childhood",
          "paediatric dysgerminoma of ovary",
          "pediatric dysgerminoma of ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A dysgerminoma that arises from the ovary and occurs in children."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004193"
    }
  ],
  "roots": [
    {
      "id": 5001,
      "label": "dysgerminoma"
    },
    {
      "id": 5339,
      "label": "ovarian primitive germ cell tumor"
    }
  ]
}