{
  "id": 5405,
  "label": "basaloid squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003486",
  "properties": {
    "xrefs": [
      "DOID:5522",
      "EFO:1001940",
      "ICDO:8083/3",
      "MEDGEN:266085",
      "NCIT:C54244",
      "UMLS:C1266005",
      "icd11.foundation:1738201981"
    ],
    "synonyms": [
      "basaloid carcinoma",
      "basaloid carcinoma (morphologic abnormality)",
      "basaloid squamous cell carcinoma",
      "basaloid squamous cell carcinoma (morphologic abnormality)"
    ],
    "definition": "A squamous cell carcinoma characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 7673,
      "label": "basaloid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000105",
          "ICDO:8123/3",
          "MEDGEN:316439",
          "NCIT:C4121",
          "UMLS:C1704216"
        ],
        "synonyms": [
          "basaloid carcinoma"
        ],
        "definition": "A malignant epithelial neoplasm characterized by the presence of neoplastic cells with hyperchromatic nuclei, small amount of cytoplasm, and peripheral nuclear palisading."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006102"
    }
  ],
  "children": [
    {
      "id": 5923,
      "label": "cervical basaloid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        7706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7046",
          "GARD:0023812",
          "MEDGEN:267027",
          "NCIT:C40189",
          "UMLS:C1511063"
        ],
        "synonyms": [
          "cervical basaloid carcinoma",
          "cervical basaloid squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An aggressive variant of cervical squamous cell carcinoma characterized by the presence of nests of malignant basaloid squamous cells with scant amount of cytoplasm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004088"
    },
    {
      "id": 5924,
      "label": "basaloid carcinoma of the penis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        20070
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7047",
          "GARD:0023813",
          "MEDGEN:231418",
          "NCIT:C6980",
          "ONCOTREE:BPSCC",
          "UMLS:C1332462"
        ],
        "synonyms": [
          "basaloid carcinoma of penis",
          "basaloid carcinoma of the penis",
          "basaloid penile squamous cell carcinoma",
          "basaloid squamous cell carcinoma of penis",
          "basaloid squamous cell carcinoma of the penis",
          "penis basaloid squamous cell carcinoma",
          "squamous cell carcinoma of penis, basaloid type",
          "squamous cell carcinoma of the penis, basaloid type",
          "BPSCC",
          "penis basaloid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An aggressive, human papillomavirus-related squamous cell carcinoma that arises from the penis. It is characterized by the presence of nests of small malignant cells. The malignant cells tend to invade deeply into the adjacent tissues. Comedo-type necrosis is often present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004089"
    },
    {
      "id": 5925,
      "label": "vulvar basaloid squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        21524
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7048",
          "GARD:0023814",
          "MEDGEN:384496",
          "NCIT:C40286",
          "UMLS:C2211850"
        ],
        "synonyms": [
          "vulvar basaloid carcinoma",
          "vulvar basaloid squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the vulva and is characterized by the presence of nests of malignant basaloid cells with a scant amount of cytoplasm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004090"
    },
    {
      "id": 5926,
      "label": "skin basaloid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        5405,
        6786
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7049",
          "MEDGEN:233446",
          "NCIT:C27543",
          "UMLS:C1335973"
        ],
        "synonyms": [
          "basaloid skin squamous cell carcinoma",
          "skin basaloid carcinoma",
          "skin basaloid squamous cell carcinoma",
          "zone of skin basaloid squamous cell carcinoma",
          "basaloid squamous cell skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A basaloid squamous cell carcinoma that involves the zone of skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004091"
    },
    {
      "id": 5927,
      "label": "thymic basaloid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        5409
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7050",
          "GARD:0023815",
          "MEDGEN:231420",
          "NCIT:C6456",
          "UMLS:C1332464"
        ],
        "synonyms": [
          "Thymus basaloid carcinoma",
          "basaloid carcinoma of Thymus",
          "basaloid carcinoma of the Thymus",
          "thymic basaloid carcinoma",
          "thymus basaloid squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare primary thymic carcinoma, characterized by the presence of tumor cell lobules with peripheral palisading, and a basophilic staining pattern. More than half of reported cases were associated with the presence of a multilocular thymic cyst. Metastases to lung and liver have been reported in approximately 30% of cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004092"
    },
    {
      "id": 5928,
      "label": "esophageal basaloid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        7225
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7051",
          "GARD:0023816",
          "MEDGEN:232156",
          "NCIT:C7032",
          "UMLS:C1333443"
        ],
        "synonyms": [
          "basaloid squamous carcinoma of esophagus",
          "basaloid squamous carcinoma of oesophagus",
          "esophageal basaloid cancer",
          "esophageal basaloid carcinoma",
          "basaloid squamous carcinoma of the esophagus",
          "basaloid squamous carcinoma of the oesophagus",
          "esophageal basaloid squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare morphologic variant of esophageal squamous cell carcinoma. Histologically, it is composed of closely packed cells with hyperchromatic nuclei and scant basophilic cytoplasm. It has a similar prognosis to the conventional squamous cell carcinoma of the esophagus. (WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004093"
    },
    {
      "id": 5959,
      "label": "anus basaloid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        7659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7174",
          "GARD:0023839",
          "MEDGEN:79125",
          "NCIT:C8256",
          "UMLS:C0280470"
        ],
        "synonyms": [
          "anal basaloid carcinoma",
          "anus basaloid squamous cell carcinoma",
          "basaloid carcinoma of anus",
          "basaloid carcinoma of the anus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An anal squamous cell carcinoma characterized by the presence of malignant cells with hyperchromatic nuclei and peripheral nuclear palisading."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004130"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 7673,
      "label": "basaloid carcinoma"
    }
  ]
}